WALLETECTOMY

 

When I was a kid food was different.  We didn’t have much packaged food.  We were 6 in my family so meals had to be affordable.  My Mom mostly made soups and stews or meat and vegetables.  We were rarely allowed sugary foods – only on birthdays. That included soda.  My Mom had a craving for salt so she would order Charles Chips by the container and sometimes their pretzels. (But those were mostly for her and she kept them hidden for special treats.)  Fruit was our snack.  Nobody in our family was overweight.  Thank you Mom!

Recently (the last decade) I’ve had the amazing opportunity to study lifestyle genetics.  I find I have all the carb sensitivity gene mutations (proven with clinical studies) and many of the fat sensitivity gene mutations.  I have blood sugar mutations.  I have a profile that would set me up to be overweight if all of those genes expressed but because my Mom had us on a low glycemic eating program, they did not express.

When I went to college I went “hog wild” and ate packaged crumb cakes, cookies, all kinds of carbs and drank soda.  No surprise I gained 25 pounds.  I managed to lose it all by taking up racquetball and for 30 years I maintained my weight with exercise.

Last year my Mom died. She had just turned 88 and had blocked arteries. Her first symptom was extreme pain. She was told she had shingles. I suggested she have a stress test.  They found the blockages.

She was recommended open heart surgery.  I work with many kinds of health professionals.  Not one of them thought that was a good idea.  If she did not have the surgery she would die.  But we (the health professionals and myself) all felt if she did have the surgery, she would not recover and the end would be beyond miserable.  My siblings encouraged her to have the surgery, I believe out of their own desire to keep her alive but also because the hospital MDs said she could make it.  They likely knew she could not survive this surgery.  They also most likely knew what her end would be like.

So why would they do that?

That is what my best friend calls a “walletectomy.”  I don’t blame MDs.  They have to follow hospital protocols or they can get sued.

So why is it the hospital protocol?

That brings us to the United States medical system.  You can’t avoid politics if you are talking about health.  The U.S is the only western country that doesn’t take care of its citizens’ health.  Right now they want to downgrade the little care they do offer.  Why?  Because the current administration values the support of business more than they value the quality of life of their citizens regardless of the spin they constantly put out.  And BTW, the alternative to truth is falsehood.

But, I digress….

After my Mom’s surgery she told me she was being “blamed” for not trying to do the exercises and recovery routines they recommended.  During this time her organs were all struggling to recover.

I’m pretty sure my Mom continued her low glycemic style of eating most of her life but I learned eventually she was an alcoholic – the secret kind.  It’s always a clue when someone BRINGS alcohol with them to visit you.  Just in case…

The point of my story is I BELIEVE in low glycemic lifestyle. Alcohol is not part of it. Alcohol will make you fat and it will contribute to heart disease.  It also puts you at a higher risk for cancer.

Once in a while is a good rule for most things.  I have a glass of red wine maybe 3 times per year and I can only drink about an inch of it because I have liver detox mutations and a whole glass will give me a hangover. Yuk.  What is once in a while for you?

I’d suggest once/week.

If you can’t do that, I’d suggest you ask yourself why.

I’m a super enthusiastic proponent of the TLS system for weight management and healthy cardiovascular system.  I highly recommend you watch this video and then do the quiz.  Does it cost money?  Yes.  Is it worth it?  YES YES YES!!!!  I will personally help you to be accountable on a daily basis, no fee.  This will be the last program you will every need to get fit. I’ll add one caveat – IF YOU ARE READY to stop yo yo-ing.

It would be my pleasure to speak to you.

If you are a health professional who would like to be the health leader you know you can be, implement epigenetics, weight management, prevention, etc. ….

It would be my pleasure to offer a complementary proposal and the support you deserve.

Kathy@criticalhealth.org, 617.515.7559.

Below is more information on cardiovascular support and weight management for the science minded, clinically trained.  This infographic is also for women. Women can commit domestic violence, assault, be aggressive, etc.

An article by Dr. David Brownstein, (MD),03/18/17 about using cholesterol to diagnose heart disease

In an on-line article in The New York Times today (3.17.17), the headline states, “Cholesterol-Slashing Drug Can Protect High-Risk Heart Patients, Study Finds.”  The article describes the first test of the new cholesterol-lowering medication—Repatha.  Repatha is part of the PCSK9 inhibiter family that works by lowering LDL-cholesterol levels through poisoning an enzyme—PCSK9–thereby allowing LDL receptors to remain in circulation.  LDL receptors can bind LDL-cholesterol, thus more LDL receptors will result in lowered LDL-cholesterol levels.

 

I have written about PCSK9 inhibitors before.  In my book, The Statin Disaster, I wrote, “I do not think PCSK9 inhibitors will be an effective treatment for heart disease as it will disrupt a normal physiologic process in the body: the binding of LDL to its receptor.” (1) So, let’s look at the first study which was published in the New England Journal of Medicine, March 17, 2017. This was a randomized, double-blind, placebo controlled trial involving 27,564 subjects with heart disease and LDL-cholesterol of 70 mg/dl or higher who were receiving statin therapy.

The primary endpoint was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization.  Keep in mind that hospitalization for angina and coronary revascularization (i.e., coronary artery bypass graft surgery or stent placement) are considered soft endpoints since the decision to hospitalize or place a stent is a subjective decision by the physician.  The ultimate success of any cardiac medication should be based on hard endpoints such as death, heart attacks, or stroke.

After 48 weeks of Repatha therapy or placebo, the authors reported that, compared to placebo, the Repatha group significantly reduced the risk of the primary end point by 15% (9.8% in the treatment group vs. 11.3% in the placebo group.)  However, as I have pointed out to you before, the 15% reduction is actually a relative risk reduction.  The relative risk is a statistical term that has no meaning when considering whether to recommend or not recommend a therapy to a patient.  A more accurate assessment is the absolute risk difference.  In this case, the absolute risk difference between the two groups is 1.5%.  A more accurate description of the results should state: as compared to placebo, taking Repatha for two years’ results in a 1.5% decline in a combination of outcomes including death, stroke, myocardial infarction, hospitalization for angina and coronary revascularization.  Another way to look at the data is that the drug failed 98.5% who took it as they received no benefit.  And, if you take out the soft endpoints, the 1.5% decline disappears.

I called Specialty Pharmacy to find out how much Repatha costs.  I was told Repatha costs $2,351.05 per month for a total of $28,212.60/year). So, a two-year course of the medication costs $56,425.20.  (Note; The NYT article states the drug costs $14,523 per year.)

For the physicians, out there, I have a question for you:  Who the heck would prescribe an expensive drug, associated with serious adverse effects, that fails 98.5% who take it?

For the patients, out there I have a question for you:  Who the heck would spend $28,212.60/year for a drug that is associated serious side effects and fails 98.5% who take it?  In this study 25% of those that received Repatha reported serious adverse effects.     What were the serious adverse effects?  I don’t know—they weren’t listed individually.

Repatha is another example about what is wrong with conventional medicine. President Trump just released his first budget.  I would advise him to start tweeting about the failure of Repatha and why it should not be allowed in the market place.  There are far too many ineffective, expensive drugs right now.  We don’t need another one.  Statins are a great example of ineffective drugs that fail nearly 99% who take them.  Now we can add PCSK9 inhibitors to the pile of poorly-performing drugs.

More information about cholesterol lowering medications can be found in my book, The Statin Disaster.

Repatha for heart disease?  Fugetaboutit!

The Triglyceride/HDL Cholesterol Ratio. What Is Ideal?

Many studies have found that the triglyceride/HDL cholesterol ratio (TG/HDL-C ratio) correlates strongly with the incidence and extent of coronary artery disease. This relationship is true both for men and women.

One study found that a TG/HDL-C ratio above 4 was the most powerful independent predictor of developing coronary artery disease.

With the increasing prevalence of overweight, obesity, and the metabolic syndrome this ratio may become even more important because high TG and low HDL-C is often associated with these disorders.

The TG/HDL-C ratio can easily be calculated from the standard lipid profile. Just divide your TG by your HDL-C.

However, when looking at the ideal ratio, you have to check if your lipid values are provided in mg/dl like in the US or mmol/L like in Australia, Canada, and most European countries.

If lipid values are expressed as mg/dl (like in the US);

TG/HDL-C ratio less than 2 is ideal

TG/HDL-C ratio above 4 is too high

TG/HDL-C ratio above 6 is much too high

If you live outside the US or are using mmol/L, you have to multiply this ratio by 0.4366 to attain the correct reference values. You can also multiply your ratio by 2.3 and use the reference values above.

If lipid values are expressed as mmol/L (like in Australia, Canada, and Europe);

TG/HDL-C ratio less than 0.87 is ideal

TG/HDL-C ratio above 1.74 is too high

TG/HDL-C ratio above 2.62 is much too high

My lifestyle genetics

My good friend Nancy Miller-Ilhi, PhD

NIH clinical study LeptiCore


INFLAMMATION – hot hot hot

Inflammation photo

 

The secret to a quality of health and well-being?

It’s not vitamins, growth hormone, emotional cleansing, detox, meditation, yoga, tender loving care (TLC) or even exercise. They all help, of course they do!

But it’s pretty clear to doctors who know their stuff what the number one factor is: you need to keep inflammation to an absolute minimum.

Inflammation is an insidious disease process that goes on in all tissues and organs and greatly accelerates change and decay.

Relaxed and efficient tissues and organs perform well but when they are hot and excited, suffering from a cascade of irritating painful chemicals known as inflammatory cytokines (everything quickly starts to break down and the aging process advances rapidly.)

Most of the diseases which are hallmarks of decay and aging have a strong inflammatory component. Cancer, heart disease, arthritis, arteriosclerosis, Alzheimer’s disease and diabetes (yes, you read those last two right)… these are all, essentially, inflammatory diseases.

Inflammation can be caused by allergies, parasites, intolerant substances, chemical pollutants, electrical and magnetic field burdens, microbes (especially hidden chronic infections) and a host of other factors.

And inflammation is cooled down by important nutrients like science based quality omega-3 fatty acids and antioxidants. Now you know why they work!

So What Can We Do?

Reduce the inflammatory load.

There is one very easy and amazingly successful way to do this. You can do it.

If you do it right you’ll look and feel years younger within a matter of months. People will say: “What are you on? I want some!” and You’ll look ten years younger. What is your secret?”

What’s the Big Secret?

It’s eliminating stressor or inflammatory epigenetics (diet, lifestyle, and chemical exposures, environment and how they impact your genes possibly your children and grandchildren).

Now this is NOT the same story as eating right for your type, the blood group diet, food combining or acid vs. alkaline foods, plant based, vegan OR ANY OTHER DIET “THEORY” although many of those matter too but YOU are unique.  This is about your genetics and your environment and using science-based solutions not marketing based-solutions.

This is about working out your own personal UNIQUE anti-inflammatory lifestyle based on YOUR genetics.

 How Can I Find Out My Genetics?

The Human Genome Project, a $3-billion project was formally founded in 1990 by the US Department of Energy and the National Institutes of Health and from that the world has changed.  The future is genetics and it is moving like a rocket ship.

Lots of people are buying genetic kits like 23AndMe, Ancestry.com, and every day new companies come to market to get a piece of this amazing pie.  Most of them do it so they can use your DNA for clinical studies.  There is nothing wrong with that and we need that but seriously why don’t they just pay you for it?

Sure they give you information BUT if you believe it won’t get into the hands of insurance companies and others who will discriminate against you (and yeah I know it is against the law) but seriously if you believe the law will protect you, I have a bridge I can sell you in Brooklyn.  You need to make sure the kit you buy is science based and they destroy your DNA without selling it to anyone.

I like to work with a genetic scientist named Keith Grimaldi who worked with Dr. Walter Gilbert, Nobel Laureate in DNA on the Human Genome Project and helped to develop the first lifestyle screening.  For as long as I’ve known him, which is since 2005, he has the highest integrity and so do the companies he works with. He won’t put a genetic SNP in his screening unless he has the science – 3 independent clinical studies proving if you change your lifestyle, you can change the expression of your DNA.

In all fairness, that’s just not true for other companies.  They put SNPs in without that kind of scientific verification.

It is the FDA’s job to monitor that but honestly, they just can’t keep up so these days we all have to be our own grassroots activist.

Your doctor most likely won’t even have any training on this unless your doctor makes it a priority (but there are health professionals who do make it a priority).

Most doctors are just keeping their head above water.  (In the U.S. they still don’t even tell their patients to take CoQ10 when they give them a statin even though it is in the literature and they’ve been packaging it together for over a decade in Europe.  That one is for you Dave.)

So Now I know My Genetics, What is a SNP (single nucleotide polymorphism)?

What is SNP

All of us have small differences in the information that our DNA contains, and it’s these differences that make each of us unique. Gene polymorphisms are slight changes in the genetic code that are present in at least one percent of the population or as much as 50% or more.

For example – one genetic “letter” (A, T, C, or G) may be replaced by another. These polymorphisms can lead to different processes in the body, just as altering one letter in a word can completely change its meaning, like MAP or MOP.  Those are very different meanings. When the change affects only one genetic letter, it is called a “single nucleotide polymorphism” (or SNP, pronounced “snip”).

 

What Are the Genetic SNPs related to Inflammation?

There are lots but remember we are looking at the ones that we KNOW you can change by changing your lifestyle.

Inflammation SNPs

What Can I DO?

Change your lifestyle and environment.  Start with what you eat.  You need to eat organic, mostly plant based and you need meat and eggs in my opinion.  Cut out simple carbs and eat less grains but this will all be different for different people; based on their genetics.

DNAFIT

Environment

Eliminate all processed foods that contain synthetic folic acid.  Eat Organic.  Avoid any unnecessary toxins to offset expression of SOD2 and other genes.

Eliminate flour, grains as much as possible.  Sometimes it is OK but there are genes that put you at risk for celiac problems.

Eliminate endocrine disruptors.  Replace plastics with glass.  Replace Teflon pans with stainless steel and other non-toxic substances. Install a whole house water filter.

Yeah I know it isn’t easy but at the risk of exposing my age my childhood had NONE of that stuff.

Exercise

Regular exercise makes your body release endorphins, which help to reduce pain and make you feel much better. So much so that exercise is now being used as a treatment for depression in some places.
Diet
In my case a low carbohydrate diet is recommended because of my very high genetic sensitivity to carbs. Managing weight is important.
Overweight is a “pro-inflammatory” condition.  I’m a big fan of lifestyle changes NOT diets.  A diet by its very definition won’t work because you go “on” and “off.”  If you don’t change lifestyle, you will gain the weight back when you stop dieting.  And yo yo dieting is the worst thing you can do for cardiovascular health.  Transitions Lifestyle System, TLS has every component demonstrated through science that helps people reach their ideal weight and most importantly, STAY THERE. It is realistic as it has a quiz built in asking the individual their goals and what they are willing to do and then recommending a plan they can stick to.

Supplementation

Everyone MUST supplement.  Dr. Mark Hyman says it best, “Maybe if we eat only wild, fresh, organic, local, non-genetically modified food grown in virgin, mineral and nutrient-rich soil that has not been transported across vast distances and stored for months before being eaten……AND work and live outside, breathe only fresh unpolluted air, drink only pure clean water, sleep nine hours per night, move the body every day, are free from chronic stressors and exposure to environmental toxins, then perhaps we might not need supplements.”

We still burn coal for energy and the by-product of burning coal is methyl-mercury.  We breathe it, it goes into our soil when it rains and it impacts (especially) root vegetables.  It goes into our water systems and impacts everything in those systems that we consume.

We’ve polluted our air, water and soil with herbicides, pesticides, chemicals and pharmaceuticals.  For example a kind of plastic, BPA will cause an increase in blood pressure.  There is almost 300,000 tons of it in the ocean alone.  We use plastics for everything now.  We should stop using plastics and Teflon coated items for food preparation and storage.

Getting Nutrition Into Your Cells

The study below shows a nutrient in two different forms. The maroon color is the nutrient in an isotonic delivery (similar to an IV with the appropriate salts and sugars added to get the ingredients to the cells asap).

The orange color is the exact same nutrient powder crushed into a tablet.  I think the table speaks for itself.

The delivery system matters.  It matters for bioavailability and it matters for speed.  And if you have genetic snps related to your digestive tract it’s even more important.

Isotonic_clinicalstudy

Omega III

It is not safe to eat fish high in fat; maybe Wild Alaskan Salmon (but then you have to deal with issues like the retailers are mislabeling so they can charge more money and regulators can’t keep up). Senator Whitehouse of RI gave a speech on the state of the oceans.  His wife is a marine biologist for the Obama Administration.  In the speech he said that the ocean is toxic.  He said when a whale beaches up on the shores of RI it is considered toxic waste.  The other problem is there is tons of plastic in the ocean.  Plastic can cause high blood pressure and other problems if consumed.  It is an endocrine disruptor. The fish are eating the plastic and tiny bits of it are showing up in their bodies and then you eat them.

Because it is critical to consume fatty-ocean products, Omega III are an alternative.  You can learn more here. It’s also critical we clean up the ocean and stop polluting it.

Omega III is a very important nutritional product for everyone. Not all Omega III are the same.  Not all Omega III have EPA and DHA in the combinations science shows are most effective and have tocotrienols to increase their impact.  They need to have sardines and anchovies from the most remote parts of the ocean, they need to remove any trace of toxins multiple times.  I like them to follow sustainable practices.  (And no I’m not satisfied that krill oil can do the same.) They won’t be cheap.

If they are, you are consuming toxic waste and wasting your money.

Probiotics

 High-quality probiotics will improve the quality and count of your healthy disease-fighting bacteria.  Some strains will even induce IL-10-producing regulatory T cells which is a scientific way of saying they reduce inflammation, and can help immune function as well as inflammatory disorders of the gut like painful Crohn’s and Ulcerative Colitis.

Antioxidants

As of 2015, there are 1149 scientific studies on antioxidants in pubmed.com.  They work.  They scavenge free radicals that cause inflammation and repair cells.  I like people to have a custom cocktail with a combination of oxygen and nitrogen free radical scavengers:

Grape Seed Extract is typically extracted from the seeds of red grapes which have a high content of compounds known as oligomeric proanthocyanadins (OPCs).  Grape seed extract is extremely rich in polyphenols, compounds with high antioxidant activity.  Many of the clinical studies examining the damage of fluoroquinolones identify oxidative stress as the underlying mechanism of their toxicity.

Red Wine Extract (Resveratrol) is a powerful antioxidant.  This extract is found in grape vines, roots, seeds and stalks, with the highest concentration in the skins.  The antioxidant properties of red wine extract contribute to maintaining healthy circulation by strengthening capillaries, arteries and veins, and promoting overall cardiovascular health.  It is also known to activate the SIRT1 gene, better known as the longevity gene.  The only other known way SIRT1 is activated is by a lifestyle of caloric restriction.

In the late 1990’s, scientists took note of a phenomenon among the French.  There were very low rates of cardiovascular problems in the provinces where residents consistently ate high fat foods and drank red wine.

Scientists concluded that the protective properties of red wine have helped the French maintain cardiovascular health for years and subsequent scientific studies have further shown that the OPCs found in red wine are particularly beneficial for protecting the heart and blood vessels.  There are also clinical studies showing resveratrol is protective of corneal endothelia.  Fluoroquinolones damage corneal endothelia and inhibit regrowth and repair.

Pine Bark Extract (Pycnogenol®) is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne.  This unspoiled and natural forest environment is the unique source of pine bark.  Pycnogenol is one of the most researched ingredients in the natural

Product marketplace.  Published findings have demonstrated Pycnogenol’s wide array of beneficial effects on the

Body.  Pine bark extract is an all-natural combination of procyanidins, bioflavonoids and organic acids.

The extract has three basic properties – it is a powerful antioxidant, selectively binds to collagen and elastin, and promotes the normal production of endothelial nitric oxide, which promotes the normal dilation of blood vessels.

As one of the most potent natural scavenger of free radicals, Pycnogenol combats many aggressive free radicals before they cause oxidative stress to vital organs.  Its super=antioxidant capabilities help support healthy blood platelet activity, support healthy blood glucose levels, reduce mild menstrual cramping and abdominal pain, maintain joint flexibility, promote cardiovascular health, promote healthy sperm quality, maintain healthy cholesterol levels and support a healthy complexion. www.pycnogenol.com

Bilberry extract is derived from the leaves and berry-like fruit of a common European shrub closely related to the blueberry. Extracts of the ripe berry are known to contain flavonoid pigments known as anthocyanins, which are powerful antioxidants. Scientific studies confirm that bilberry extract supports healthy vision and venous circulation. Bilberry extract helps maintain healthy circulation by strengthening capillaries, arteries and veins.

Bioflavonoids are antioxidants found in certain plants that act as light filters, which protect delicate DNA chains and other important macromolecules

by absorbing ultraviolet radiation. They have been found to promote cardiovascular health, help maintain healthy circulation by strengthening capillaries, arteries and veins , and demonstrate anti-inflammatory activity.

Cranberry is a small evergreen shrub containing dark pink flowers that grows in damp bogs and mountain forests. It blooms from late spring until the end of the summer. The shrub’s small red fruits are produced in the fall. The therapeutic properties of the plant come from the fruit. Cranberries contain proanthocyanidin, which are helpful in promoting a healthy urinary tract and supporting a normal pH of urine. Preliminary evidence suggests that cranberries increase the antioxidant levels of plasma and may help maintain healthy cholesterol levels by providing antioxidant protection of LDL particles.   Cranberries have a high ORAC value, next to blueberries.

Blueberries rank highest among many fruits and vegetables for ORAC activity and contain 25-30 different types of anthocyanins. Anthocyanins give blueberries (and other fruits) their rich blue and red coloring, and are a powerful flavonoid antioxidant. The mechanism of action surrounding anthocyanins has been studied at the molecular level, demonstrating effects such as promoting cellular health. Blueberries provide large amounts of chlorogenic acid, which is thought to be important in promoting cellular health. Blueberries support the body’s COX-2 inhibitors and provide a powerful antioxidant defense, supporting a strong, comprehensive antioxidant network within the body.

Grapes contain a variety of phenolic compounds, including anthocyanidins, cinnamates and flavan-3-ols, which have all been shown to be effective in promoting cardiovascular health. Anthocyanidins are powerful flavonoid antioxidants that contribute to maintaining cellular health. Preliminary evidence suggests that anthocyanidins contribute to supporting healthy capillaries and providing antioxidant protection of LDL particles, which help to maintain healthy cholesterol levels and contribute to overall cardiovascular health.

Raspberries contain significant amounts of polyphenol antioxidants, chemicals linked to promoting endothelial and cardiovascular health. Raspberries are high in fiber, are an excellent source of vitamin C and manganese, a good source of vitamin K and magnesium, and contain some calcium and iron.

Raspberries are powerful antioxidants, particularly due to their dense contents of ellagic acid (from ellagotannins), quercetin, gallic acid, anthocyanins, cyanidins, pelargonidins, catechins, kaempferol and salicylic acid. They have a high ORAC value next to cranberries and blueberries.

Elderberries contain the flavonoids rutin, isoquertin and hyperoside, as well as anthocyan glycosides, an essential oil. Elderberries have historically been used to make elderberry wine, elder brandy, and sambuca, a popular cordial. Elderberries have a high ORAC value, and contribute to promoting a comprehensive antioxidant network and stimulating the immune system.

Black Currants are powerful antioxidants, particularly due to their anthocyanins content. They are rich sources of vitamin C, and contain high concentrations of B-vitamins, vitamin A, potassium, magnesium, iron, and calcium. Black currants have a high ORAC value. They contribute to promoting a comprehensive antioxidant network, stimulating the immune system and promoting cardiovascular health.

Pomegranate Extract
One pomegranate delivers 40 percent of an adult’s daily vitamin C requirement, and is a rich source of folic acid and antioxidants. Pomegranates are high in polyphenols. The most abundant polyphenols in pomegranate are hydrolysable tannins, particularly punicalagins, which research has shown to be the antioxidant responsible for the free-radical scavenging ability of pomegranate juice. Many food and dietary supplement makers have found the advantages of using pomegranate extracts (which have no sugar, calories or additives), instead of the juice, as healthy ingredients in their products. Many pomegranate extracts are essentially ellagic acid, which is largely a by-product of the juice extraction process. Ellagic acid has been shown in published studies to absorb into the body when consumed as ellagitannins, such as punicalagins.

Plum Powder contains several powerful antioxidants, with a high ORAC content. They are rich sources of many essential vitamins and minerals.  They are also rich in dietary fiber, sorbitol and isatin. They have been commonly used to promote digestive health, but also contribute to a comprehensive antioxidant network, promote cognitive health and cardiovascular health.

Chokeberries are powerful antioxidants due to their high anthocyanins content. They are rich in vitamins and minerals, and contribute to general health and well-being. They contribute to a comprehensive antioxidant network, scavenging free radicals and promoting antioxidant protection of LDL particles.

Bioperine® is a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper). It contains 95 percent of piperine. The metabolic process that generates energy at the cellular level in the human body is called thermogenesis. Though thermogenesis has been identified as a key factor in maintaining weight loss, it has also been identified as playing an integral role in utilizing the daily food and nutrients that the human body consumes.

It sets in motion the mechanisms that lead to digestion and subsequent gastrointestinal absorption. Piperine, in the patented form of Bioperine®, promotes the body’s natural thermogenic activity. Bioperine enhances the bioavailability of certain nutrients, especially antioxidants.

Vitamin C is found in peppers (sweet, green, red, hot red and green chili), citrus fruits, brussels sprouts, cauliflower, cabbage, kale, collards, mustard greens, broccoli, spinach, guava, kiwi fruit, currants and strawberries. Nuts and grains contain small amounts of vitamin C. It is important to note that cooking destroys vitamin C activity. Vitamin C is integral in supporting a healthy immune system, promoting cardiovascular health, maintaining healthy cholesterol levels and providing an antioxidant defense. The body does not manufacture vitamin C on its own, nor does it store it. Therefore, vitamin C must be acquired through diet and supplementation.

Vitamin E (Natural tocopherol: d-gamma 70%, d-delta 21%, d-alpha 7%, d-beta 2%): is a collective term for a group of compounds from the tocopherol and tocotrienol chemical groups. The most valuable sources of dietary vitamin E include vegetable oils, margarine, nuts, seeds, avocados and wheat germ. Safflower oil contains large amounts of vitamin E (about two thirds of the RDA in ¼ cup), and there are trace amounts in corn oil and soybean oil. Vitamin E is available in a natural or synthetic form. In most cases, the natural and synthetic forms are identical except the natural form of vitamin E is better absorbed and retained in the body. For those individuals watching their dietary fat consumption, which is relatively common in the world of dieting, vitamin E intake is likely to be low, due to a reduced intake of foods with high fat content. The main health benefit of supplemental vitamin E comes from its immune-boosting antioxidant activity. It is also known to provide protection for the cardiovascular system.

Vitamin E is one of the most powerful fat-soluble antioxidants in the body. In turn, vitamin E protects cell membranes from free radicals.  (Most oils are GMO these days and are Omega 6 which is much too abundant in the American diet.)  I prefer a high quality supplement that doesn’t use GMOs.

The combination of vitamins C and E helps form the antioxidant network, allowing the vitamins to engage (synergistically) in each others’ regeneration from the spent state back to the active antioxidant state so that they can continue neutralizing free radicals.

Tocotrienols (mixed isomers)
Palm tocotrienols, along with tocopherols, are members of the vitamin E family and are extracted from the fruit of the palm tree. Tocotrienols are one of the two related families of compounds that are collectively regarded as vitamin E. As mentioned above, vitamin E is one of the most powerful fat-soluble antioxidants in the body, and the antioxidant properties of tocotrienols appear to be superior to those of tocopherols. Dietary sources of tocotrienols include almonds, rice bran oil, pistachios, palm oil and barley. Like vitamin E, palm tocotrienols also help maintain a healthy level of HMG-CoA reductase, a key enzyme in our bodies used by the liver to produce cholesterol. New data on the biological activity of tocotrienols in cardiovascular health maintenance along with its antioxidant properties have raised tocotrienols to a new level of prominence in the scientific community.

Lutein and Zeaxanthin are carotenoids found together in many fresh fruits and vegetables. Within the eye, they are found as pigments in the macula and retina. Lutein and Zeaxanthin act as antioxidants to protect the eye from free radical damage. They help to build macular pigment density, a critical factor in the health of the macula and retina in relation to the clarity of the lens. They also act as filters of blue-light to protect the photoreceptor cells of the retina from light damage. Blue-light wave lengths can generate free radical damage.

Eyebright® is an annual plant with deeply-cut leaves and small, white or purple flowers variegated with yellow, native to Great Britain. There are over 20 species of eyebright that extend over Europe, Northern and Western Asia, and North America. The medicinal portion of eyebright comes from fluid extracted just above the root only when the plant is in bloom.

Eyebright is used for the inflammation of the eyelids, sties and eye fatigue. Eyebright has been used by herbalist since the 16th century for problems of the eyes.

Copper may have some antioxidant properties and acts as a component of enzymes in iron metabolism. It is an essential trace mineral. Copper is needed in normal infant development, iron transport, bone strength, cholesterol metabolism, myocardial contractility, glucose metabolism, brain development and immune function.

Zinc is a component of multiple enzymes and proteins. It is also involved in the regulation of gene expression. Zinc is an essential trace mineral that has functions in approximately 300 different enzyme reactions. Thus, zinc plays a part in almost all biochemical pathways and physiological processes. More than 90 percent of the body’s zinc is stored in the bones and muscles, but zinc is also found in virtually all body tissues. It has been claimed that zinc plays a role in wound healing, immune system support, promoting a healthy prostate gland and supports healthy sperm quality. Because zinc is involved in such a great number of enzymatic processes, it has been found to positively affect a large range of functions, including digestion, energy production, growth, cellular repair, collagen synthesis, bone strength, cognitive function and carbohydrate metabolism.

 Quercetin® is a bioflavonoid that is an excellent antioxidant working synergistically with vitamin C to strengthen the walls of the intricate blood vessels in the eye. It also helps to maintain lens transparency. Quercetin has been shown to inhibit the enzyme, aldose reductase. Aldose reductase has been known to contribute to poor eye health.

L-Taurine is a building block for all the other amino acids. It aids in the transport of potassium, sodium, calcium and magnesium in and out of cells, thus helping to generate nerve impulses. It is a non-protein amino acid and is found in high amounts in the brain, retina, myocardium, skeletal and smooth muscle, platelets and neutrophils. It is plentiful in the fluids of muscle, lungs and nerve tissue. It is classified as an essential amino acid and aids micelle formation and fat absorption. Further, it promotes alertness, mental energy and focus.

Taurine also has antioxidant and membrane-stabilizing activities. It may also help maintain a healthy cardiovascular system while also delivering detoxifying activities. It helps protect the eyes from the harmful effects of UV light and stabilizes the membranes in the cones cells of the eye.

It also supports healthy cholesterol and blood pressure levels. It may also help maintain a healthy cardiovascular system while also delivering detoxifying activities.*

Lycopene is one of the carotenes and a member of the carotenoid family. Lycopene offers a wide range of benefits in helping maintain healthy cardiovascular health, prostate health and powerful antioxidant. More recent research suggests that lycopene, like beta-carotene, may play an important role in keeping vision healthy by preventing cataracts and Age-Related Macular Degeneration (AMD).

Activated B-Complex® With Quatrefolic – People with MTHFR polymorphisms need active ingredients especially folate. Some of the bodily functions that need support of B-complex are nervous system, digestive system, cardiovascular system, skin health, mitochondrial health and cognitive health.  They are easily depleted by our environment, especially prescription medication.

I recommend purchasing from Shop.com, the only legitimate distributor of science based, isotonic nutrition.  There are many dubious knock offs, possibly adulterated and expired on other sites so caution advised.

 

 


Digestive Disorders, Genetics and Epigenetics

Crohns_Ulcerative

 

Digestive Disorders….

Crohn’s disease has an energetic, or vibrational, underlying cause conditioned by mental and emotional patterns of thoughts and feeling-reactions that maintain an underlying condition of stress in the physical body. These underlying stress-producing energetic patterns keep the body in a fight or flight response mode.

Any treatment to bring about a “cure” of Crohn’s disease must necessarily include addressing this underlying energetic cause. Without this factor properly addressed and cleared, all treatments, medical and/or alternative, will only bring about relief and management of the condition.
Crohn’s disease is usually preceded by chronic indigestion. The cause of Crohn’s disease, diverticulitis, colitis and irritable bowel syndrome (IBS) is probably chronic indigestion.

Here is the definition of Crohn’s disease taken from the Mayo Clinic
“Crohn’s disease is a chronic inflammatory disease of the intestines. It primarily causes ulcerations (breaks in the lining) of the small intestines, but can affect the digestive system anywhere from the mouth to the anus. It is named after the physician who described the disease in 1932. It also is called granulomatous enteritis or colitis, regional enteritis, ileitis, or terminal ileitis.”

(Note: The Ileum is another name for the last section of the small intestines, the part that connects to the large intestines (or ascending colon), which is where the appendix is also located.)

To answer the question “What causes Crohn’s disease?” one must first answer the question “What causes inflammation in the intestines?” Right? So, let’s think this through by following the digestive process. But first let’s look at the inflammatory process.

The Cause of Inflammation
What causes inflammation is the immune system. It’s the body’s way of dealing with infection. Infection is the immune system’s way of dealing with foreign matter that is not being eliminated. Food is foreign matter to the body. It is supposed to be digested and then eliminated from the intestinal tract.  There are also genetic polymorphisms like TNF, IL6 and CRP that contribute to excessive inflammation. (While still controversial, studies of depression and IBD are currently being linked to TNF levels.)

Remember, the inside of the alimentary canal, from the mouth to the rectum, is outside the body, although it runs through it. In other words, it is part of the body’s immediate environment, just as dirt on your skin is external to the body. In fact, the lining of the intestines is made from the same matrix of tissue (ectoderm) as skin. It’s a membrane. In other words, it’s skin.

The brain and nervous system are also made from the same matrix, the ectoderm. Skin is an organ of elimination and has intelligence. It is a very permeable membrane, however, letting in what will nourish the body and eliminating what is toxic and not handled by the other organs and glands of elimination. The pH of the skin is a crucial aspect of its integrity. High acidity will break it down. Inflammation is created by the immune system, which is very pervasive throughout the intestines and colon, in order to deal with the foreign substance that is irritating the membrane.

It is literally a fire, a localized febrile condition created to burn up toxins and dying cells.

Food that is not properly digested will cause acidity in the intestines. Undigested protein will rot causing putrefaction. Undigested carbohydrates will ferment. Undigested fats will go rancid. Rancid fats destroy tissue immediately upon contact. This is why it is not good to eat rancid seeds and nuts or use rancid cooking and salad oils. They also destroy HDL, the so called “good” cholesterol. Cholesterol is essential to the structural composition of the cell wall . . . every one of the 100 trillion cells that make up your body.

Digestion of Proteins and Carbohydrates
Protein is broken down and digested in the stomach by hydrochloric acid (HCL). Hydrochloric acid is secreted by the parietal cells lining the stomach at a pH (potential of Hydrogen) of 0.8, very acidic, and by the time it mixes with the stomach contents its pH increases to about 2.5. Pepsin is the activating enzyme for HCL.e food during mastication – which is why it is important to chew food thoroughly before swallowing. Lypase is the activating enzyme for the digestion of fats.  Environmental factors like food transportation have reduced the enzymes in food that help us to digest that food.  Food is frequently picked before it is ripe.

HCL production in the stomach begins to decline around age 45, and our enzyme reserve runs low, so it is supportive of digestion to take digestive enzymes and probiotics.

Poor Digestion and Stress
The function of the parietal cells, like all cells in the body, depends largely upon adrenalin. Stress puts the body in fight or flight mode sending most of the adrenalin to the muscle cells.

The body is not interested in growth and healing when it is focused on survival or running away from a stressor, such as a charging bull, a stressful job or lifestyle, or long-term grieving and mental and emotional distress. Toxins inhaled or ingested bring on stress just as surely as any other external stressors. This is why cigarette smoking keeps the lining of the stomach inflamed, mainly from the chemicals (some 300 of them in the paper and tobacco).  Endocrine disruptors in the environment, like plug in chemical air fresheners contribute to stress. The genetic polymorphism MTHFR tends to contribute to a buildup of toxins. IBS, Crohns and Ulcerative Colitis are conditions associated with this genetic polymorphism.  MTHFR can also impact the creation of betaine in the methylation cycle.  Many people also have genetic mutations impacting their ability to digest carbohydrates  like ACE, PPARG, ADRB2, FABP2 and TCF7L2.

Fat genetic mutations will also be challenging for the digestive tract like FTO, LPL, FABP2, APOC3 and APOA2.

Poor nutrition puts the body cells in a state of starvation stress as well. When there’s stress, the parietal cells of the stomach shut down the production of hydrochloric acid, rendering protein digestion problematic. Mental and emotional stress also produces acidosis throughout the body.

When protein is not digested properly produces putrid matter. Putrefaction produces organic acids, which will erode the stomach and intestinal linings. The acids of putrefaction and fermentation are what cause “acid indigestion” and “heart burn.”

It is not the hydrochloric acid that causes these symptoms, including ulcers. In fact, it is the lack of hydrochloric acid that creates the condition of indigestion that leads to putrefaction of proteins. So when a person has “heart burn” after eating, while antacids do relieve the symptoms, they also cancel out the hydrochloric acid needed for digestion.

So when a person has “acid indigestion” and “heartburn” s/he needs some digestive support.

To take chemicals that stop the production of digestive stomach acids only adds insult to injury. We have to add digestive acids to the stomach not eliminate them. Pharmaceutical grade Aloe Juice for calming the digestive tract, antioxidants for healing it, Active B Complex (5-MTHF) to support MTHFR, digestive enzymes and probiotics are one of the solutions. IV or Isotonic delivery is important because the digestive tract is stressed. Isotonic delivery skips the whole process and goes right to the cells that need relief.  Isotonic Wellmune is also recommended as it contains patented beta-glucans that activate your innate immunity to better react to and neutralize foreign invaders of your body. It can also benefit the “depression”  associated with the genetic polymorphism TNF.

The Digestive Process and the pH Factor
The gallbladder and pancreas produce copious amounts of sodium-rich bile and alkaline juices respectively to emulsify fat and buffer the 2.5 pH acids of digestion in the chyme (stomach contents) coming out of the stomach into the duodenum, the first 12 inches of the small intestines. The intestines, which are ideally happy with a 5.8 to 6.2 pH, would be distressed and burned by 2.5 pH content.
So, it is important that the gallbladder and pancreas produce their alkaline substances to buffer this acid. Otherwise duodenal ulcers may develop. The colon, on the other hand, likes a more acidic environment – for one thing, to keep yeast and fungus from growing and thereby giving rise to infection.

What can cause these alkaline substances to be depleted of alkalizing sodium? Well, for one thing, over consumption of acid-producing foods – grains and proteins – which use a lot of acid-buffering sodium. What builds up sodium reserves? Vegetables, especially celery and cucumbers, and some fruits, such as prunes, plums and blueberries, are alkaline producing foods that build up your sodium reserves. These alkaline-producing foods should ideally make up 80% of our diet.

When bile loses it alkalinity, it becomes thick and therefore cannot easily flow through the small common-bile duct. Fat is not emulsified and therefore hardens to form stones. Calcium will precipitate out of solution and crystallize, creating calcium stones. When bile does not flow into the duodenum through the common-bile duct, the acid of the chyme does not get properly buffered and the fats are not emulsified. This creates an acid condition that will burn the small intestines, causing irritable bowel (IBS) and colitis.

Bacteria, viruses and other pathogens will thrive in this acid environment. This leads to inflammation and infection, the immune system’s way of dealing with pathogens. Crohn’s disease develops as the lining of the intestines begins to get raw, eaten up by these organic acids. This is why it will appear as “raw hamburger meat” in a colonoscopy. In this compromised condition, bacteria and viruses, along with undigested proteins and other toxins, easily enter the blood stream through the “leaky gut,” causing so-called “food allergies,” as well as infection throughout the body, including the kidneys and bladder, organs of elimination of toxic waste fluids.

Symptom Relief without side effects

Pharmaceutical grade Aloe Juice has anti-bacterial, anti-viral and anti-carcinogenic properties.  It calms and soothes skin, especially burning skin inside and out. Most Aloe product are not pharmaceutical grade so it is best to get the recommendation of a certified health professional. Antioxidants will repair cellular damage and scavenge free radicals. Isotonic delivery is recommended for optimal bioavailability.

5-MTHF (activated folate) will help the methylation cycle and DNA repair and functioning.  Digestive Enzymes and Probiotics will help digestion and boost and support good bacteria in the gut. Many health professionals have written books on how bad industrialized food is now.  We are seeing epidemics of digestive disorders in young people. This generation faces the worst toxic burden so far. GMOs have BT toxin injected into their DNA. Much more glyphosate is used on GMO food with surfactants (Roundup) that make it worse.  It is patented as an antibiotic therefore likely contributes to stronger toxic bacteria that are resistant.  The World Health Organization has classified glyphosate as a class 1 carcinogen. Organic food is recommended.  Eliminate endocrine disruptors from the environment as much as possible.

THE CURE

The “cure” of Crohn’s disease lies in the healing of the lining of the intestinal wall, factoring in genetics and epigenetics. It also includes treating and clearing the underlying energetic patterns of stress, as mentioned at the start of this article.

Emotional Factors

In her wonderful and popular book, “You Can Heal Your Life,” Louise Hay suggests that behind inflammation in the colon (ileitis), which is whiat Crohns is, may be a deep sense of fear and worry of not being “good enough.” This deeply rooted pattern was likely put there early in childhood by a well-meaning parent who tried to motivate a child by telling her how stupid she is, screaming and berating her for not being able to do anything right.

A new thought pattern she offers could be: “I love and approve of myself. I am doing the best I can. I am wonderful. I am at peace.”

Genetics

This infographic identifies all of the genetic variants named in this article. It is a snapshot of the 45 genetic polymorphisms that each have 3 independent clinical studies showing a change in expression with a change in lifestyle. The company does not sell DNA to pharmaceutical companies. These are my results.  Notice I have a very high sensitivity to carbohydrates and medium sensitivity to fats.  I knew that from my experience but I did not know I had genetics that put me at risk for Celiac Disease.  The B vitamin snapshot shows I have MTHFR. I have used all the protocols I describe.  Other symptoms of mine that have disappeared are allergies, sinus headaches, night terrors, IBS and heart palpitations.  Notice I also have a need for extra Omega III and Vitamin D as well as cruciferous and alium vegetables.  (Curcumin in the form of BCM-95 with tumeric and added broccoli concentrate can also benefit in a pinch if you can’t get your 6-12 servings of vegetables in.  That is tough for anyone working full time. To have quality food you darn near have to grow your own.  Add  in lack of nutrients in the soil, premature harvesting, pesticides, methyl mercury fallout from burning coal, pharmaceutical contamination of water, compromised environmental policies by moneyed corporate interests controlling politics, etc. can we really expect to achieve optimal health just from eating food?)

DNAFIT

This article took me 12 years to write.  It is compiled from many cutting edge professionals, one of the top genetic scientists in the world, Dr. Keith Grimaldi, my work with cutting edge Allopathic health professionals and CAMs, and my own urgency to help someone I love deeply.  There is plenty of science to back all of it up.  I learned by Googling, Pubmed, science based sites, scientists and health professionals who have success. We all need science but none of us should have to wait the years it will take for clinical studies and medical schools to catch up, especially when the protocols are benign and effective and there are pharmaceutical and insurance moneyed interests blocking many progressive moves toward prevention and optimal health.  To learn more in detail about protocols go to my youtube channel, Kathy Kaufman Videos.  Write me at kathy@criticalhealth.org.

A special thanks to my friend Michael Sweringen of Microleadership.  He helped lead me to all of the climate and environmental information that got me thinking about epigenetics.  And Dr. Keith Grimaldi, a brilliant genetic scientist and good man.

And lastly, the FDA has not evaluated any of this information. If only they would.