Digestive Disorders, Genetics and Epigenetics

Crohns_Ulcerative

 

Digestive Disorders….

Crohn’s disease has an energetic, or vibrational, underlying cause conditioned by mental and emotional patterns of thoughts and feeling-reactions that maintain an underlying condition of stress in the physical body. These underlying stress-producing energetic patterns keep the body in a fight or flight response mode.

Any treatment to bring about a “cure” of Crohn’s disease must necessarily include addressing this underlying energetic cause. Without this factor properly addressed and cleared, all treatments, medical and/or alternative, will only bring about relief and management of the condition.
Crohn’s disease is usually preceded by chronic indigestion. The cause of Crohn’s disease, diverticulitis, colitis and irritable bowel syndrome (IBS) is probably chronic indigestion.

Here is the definition of Crohn’s disease taken from the Mayo Clinic
“Crohn’s disease is a chronic inflammatory disease of the intestines. It primarily causes ulcerations (breaks in the lining) of the small intestines, but can affect the digestive system anywhere from the mouth to the anus. It is named after the physician who described the disease in 1932. It also is called granulomatous enteritis or colitis, regional enteritis, ileitis, or terminal ileitis.”

(Note: The Ileum is another name for the last section of the small intestines, the part that connects to the large intestines (or ascending colon), which is where the appendix is also located.)

To answer the question “What causes Crohn’s disease?” one must first answer the question “What causes inflammation in the intestines?” Right? So, let’s think this through by following the digestive process. But first let’s look at the inflammatory process.

The Cause of Inflammation
What causes inflammation is the immune system. It’s the body’s way of dealing with infection. Infection is the immune system’s way of dealing with foreign matter that is not being eliminated. Food is foreign matter to the body. It is supposed to be digested and then eliminated from the intestinal tract.  There are also genetic polymorphisms like TNF, IL6 and CRP that contribute to excessive inflammation. (While still controversial, studies of depression and IBD are currently being linked to TNF levels.)

Remember, the inside of the alimentary canal, from the mouth to the rectum, is outside the body, although it runs through it. In other words, it is part of the body’s immediate environment, just as dirt on your skin is external to the body. In fact, the lining of the intestines is made from the same matrix of tissue (ectoderm) as skin. It’s a membrane. In other words, it’s skin.

The brain and nervous system are also made from the same matrix, the ectoderm. Skin is an organ of elimination and has intelligence. It is a very permeable membrane, however, letting in what will nourish the body and eliminating what is toxic and not handled by the other organs and glands of elimination. The pH of the skin is a crucial aspect of its integrity. High acidity will break it down. Inflammation is created by the immune system, which is very pervasive throughout the intestines and colon, in order to deal with the foreign substance that is irritating the membrane.

It is literally a fire, a localized febrile condition created to burn up toxins and dying cells.

Food that is not properly digested will cause acidity in the intestines. Undigested protein will rot causing putrefaction. Undigested carbohydrates will ferment. Undigested fats will go rancid. Rancid fats destroy tissue immediately upon contact. This is why it is not good to eat rancid seeds and nuts or use rancid cooking and salad oils. They also destroy HDL, the so called “good” cholesterol. Cholesterol is essential to the structural composition of the cell wall . . . every one of the 100 trillion cells that make up your body.

Digestion of Proteins and Carbohydrates
Protein is broken down and digested in the stomach by hydrochloric acid (HCL). Hydrochloric acid is secreted by the parietal cells lining the stomach at a pH (potential of Hydrogen) of 0.8, very acidic, and by the time it mixes with the stomach contents its pH increases to about 2.5. Pepsin is the activating enzyme for HCL.e food during mastication – which is why it is important to chew food thoroughly before swallowing. Lypase is the activating enzyme for the digestion of fats.  Environmental factors like food transportation have reduced the enzymes in food that help us to digest that food.  Food is frequently picked before it is ripe.

HCL production in the stomach begins to decline around age 45, and our enzyme reserve runs low, so it is supportive of digestion to take digestive enzymes and probiotics.

Poor Digestion and Stress
The function of the parietal cells, like all cells in the body, depends largely upon adrenalin. Stress puts the body in fight or flight mode sending most of the adrenalin to the muscle cells.

The body is not interested in growth and healing when it is focused on survival or running away from a stressor, such as a charging bull, a stressful job or lifestyle, or long-term grieving and mental and emotional distress. Toxins inhaled or ingested bring on stress just as surely as any other external stressors. This is why cigarette smoking keeps the lining of the stomach inflamed, mainly from the chemicals (some 300 of them in the paper and tobacco).  Endocrine disruptors in the environment, like plug in chemical air fresheners contribute to stress. The genetic polymorphism MTHFR tends to contribute to a buildup of toxins. IBS, Crohns and Ulcerative Colitis are conditions associated with this genetic polymorphism.  MTHFR can also impact the creation of betaine in the methylation cycle.  Many people also have genetic mutations impacting their ability to digest carbohydrates  like ACE, PPARG, ADRB2, FABP2 and TCF7L2.

Fat genetic mutations will also be challenging for the digestive tract like FTO, LPL, FABP2, APOC3 and APOA2.

Poor nutrition puts the body cells in a state of starvation stress as well. When there’s stress, the parietal cells of the stomach shut down the production of hydrochloric acid, rendering protein digestion problematic. Mental and emotional stress also produces acidosis throughout the body.

When protein is not digested properly produces putrid matter. Putrefaction produces organic acids, which will erode the stomach and intestinal linings. The acids of putrefaction and fermentation are what cause “acid indigestion” and “heart burn.”

It is not the hydrochloric acid that causes these symptoms, including ulcers. In fact, it is the lack of hydrochloric acid that creates the condition of indigestion that leads to putrefaction of proteins. So when a person has “heart burn” after eating, while antacids do relieve the symptoms, they also cancel out the hydrochloric acid needed for digestion.

So when a person has “acid indigestion” and “heartburn” s/he needs some digestive support.

To take chemicals that stop the production of digestive stomach acids only adds insult to injury. We have to add digestive acids to the stomach not eliminate them. Pharmaceutical grade Aloe Juice for calming the digestive tract, antioxidants for healing it, Active B Complex (5-MTHF) to support MTHFR, digestive enzymes and probiotics are one of the solutions. IV or Isotonic delivery is important because the digestive tract is stressed. Isotonic delivery skips the whole process and goes right to the cells that need relief.  Isotonic Wellmune is also recommended as it contains patented beta-glucans that activate your innate immunity to better react to and neutralize foreign invaders of your body. It can also benefit the “depression”  associated with the genetic polymorphism TNF.

The Digestive Process and the pH Factor
The gallbladder and pancreas produce copious amounts of sodium-rich bile and alkaline juices respectively to emulsify fat and buffer the 2.5 pH acids of digestion in the chyme (stomach contents) coming out of the stomach into the duodenum, the first 12 inches of the small intestines. The intestines, which are ideally happy with a 5.8 to 6.2 pH, would be distressed and burned by 2.5 pH content.
So, it is important that the gallbladder and pancreas produce their alkaline substances to buffer this acid. Otherwise duodenal ulcers may develop. The colon, on the other hand, likes a more acidic environment – for one thing, to keep yeast and fungus from growing and thereby giving rise to infection.

What can cause these alkaline substances to be depleted of alkalizing sodium? Well, for one thing, over consumption of acid-producing foods – grains and proteins – which use a lot of acid-buffering sodium. What builds up sodium reserves? Vegetables, especially celery and cucumbers, and some fruits, such as prunes, plums and blueberries, are alkaline producing foods that build up your sodium reserves. These alkaline-producing foods should ideally make up 80% of our diet.

When bile loses it alkalinity, it becomes thick and therefore cannot easily flow through the small common-bile duct. Fat is not emulsified and therefore hardens to form stones. Calcium will precipitate out of solution and crystallize, creating calcium stones. When bile does not flow into the duodenum through the common-bile duct, the acid of the chyme does not get properly buffered and the fats are not emulsified. This creates an acid condition that will burn the small intestines, causing irritable bowel (IBS) and colitis.

Bacteria, viruses and other pathogens will thrive in this acid environment. This leads to inflammation and infection, the immune system’s way of dealing with pathogens. Crohn’s disease develops as the lining of the intestines begins to get raw, eaten up by these organic acids. This is why it will appear as “raw hamburger meat” in a colonoscopy. In this compromised condition, bacteria and viruses, along with undigested proteins and other toxins, easily enter the blood stream through the “leaky gut,” causing so-called “food allergies,” as well as infection throughout the body, including the kidneys and bladder, organs of elimination of toxic waste fluids.

Symptom Relief without side effects

Pharmaceutical grade Aloe Juice has anti-bacterial, anti-viral and anti-carcinogenic properties.  It calms and soothes skin, especially burning skin inside and out. Most Aloe product are not pharmaceutical grade so it is best to get the recommendation of a certified health professional. Antioxidants will repair cellular damage and scavenge free radicals. Isotonic delivery is recommended for optimal bioavailability.

5-MTHF (activated folate) will help the methylation cycle and DNA repair and functioning.  Digestive Enzymes and Probiotics will help digestion and boost and support good bacteria in the gut. Many health professionals have written books on how bad industrialized food is now.  We are seeing epidemics of digestive disorders in young people. This generation faces the worst toxic burden so far. GMOs have BT toxin injected into their DNA. Much more glyphosate is used on GMO food with surfactants (Roundup) that make it worse.  It is patented as an antibiotic therefore likely contributes to stronger toxic bacteria that are resistant.  The World Health Organization has classified glyphosate as a class 1 carcinogen. Organic food is recommended.  Eliminate endocrine disruptors from the environment as much as possible.

THE CURE

The “cure” of Crohn’s disease lies in the healing of the lining of the intestinal wall, factoring in genetics and epigenetics. It also includes treating and clearing the underlying energetic patterns of stress, as mentioned at the start of this article.

Emotional Factors

In her wonderful and popular book, “You Can Heal Your Life,” Louise Hay suggests that behind inflammation in the colon (ileitis), which is whiat Crohns is, may be a deep sense of fear and worry of not being “good enough.” This deeply rooted pattern was likely put there early in childhood by a well-meaning parent who tried to motivate a child by telling her how stupid she is, screaming and berating her for not being able to do anything right.

A new thought pattern she offers could be: “I love and approve of myself. I am doing the best I can. I am wonderful. I am at peace.”

Genetics

This infographic identifies all of the genetic variants named in this article. It is a snapshot of the 45 genetic polymorphisms that each have 3 independent clinical studies showing a change in expression with a change in lifestyle. The company does not sell DNA to pharmaceutical companies. These are my results.  Notice I have a very high sensitivity to carbohydrates and medium sensitivity to fats.  I knew that from my experience but I did not know I had genetics that put me at risk for Celiac Disease.  The B vitamin snapshot shows I have MTHFR. I have used all the protocols I describe.  Other symptoms of mine that have disappeared are allergies, sinus headaches, night terrors, IBS and heart palpitations.  Notice I also have a need for extra Omega III and Vitamin D as well as cruciferous and alium vegetables.  (Curcumin in the form of BCM-95 with tumeric and added broccoli concentrate can also benefit in a pinch if you can’t get your 6-12 servings of vegetables in.  That is tough for anyone working full time. To have quality food you darn near have to grow your own.  Add  in lack of nutrients in the soil, premature harvesting, pesticides, methyl mercury fallout from burning coal, pharmaceutical contamination of water, compromised environmental policies by moneyed corporate interests controlling politics, etc. can we really expect to achieve optimal health just from eating food?)

DNAFIT

This article took me 12 years to write.  It is compiled from many cutting edge professionals, one of the top genetic scientists in the world, Dr. Keith Grimaldi, my work with cutting edge Allopathic health professionals and CAMs, and my own urgency to help someone I love deeply.  There is plenty of science to back all of it up.  I learned by Googling, Pubmed, science based sites, scientists and health professionals who have success. We all need science but none of us should have to wait the years it will take for clinical studies and medical schools to catch up, especially when the protocols are benign and effective and there are pharmaceutical and insurance moneyed interests blocking many progressive moves toward prevention and optimal health.  To learn more in detail about protocols go to my youtube channel, Kathy Kaufman Videos.  Write me at kathy@criticalhealth.org.

A special thanks to my friend Michael Sweringen of Microleadership.  He helped lead me to all of the climate and environmental information that got me thinking about epigenetics.  And Dr. Keith Grimaldi, a brilliant genetic scientist and good man.

And lastly, the FDA has not evaluated any of this information. If only they would.


Weight Management

 

One Size Doesn’t Fit All

Weight Management is personal.  People are different.  Have you noticed?  Should you be on a low carb diet?  Well if you look at the genetics of the person below the answer is resoundingly YES.

He is very sensitive to carbohydrates and saturated fats. He has a high risk of injury so he has to consider that with his exercise program and he should be adding power and endurance.  After all, muscle dictates metabolism.

 

Some people are not sensitive to carbohydrates and they should be eating more of a Mediterranean style diet.

 

Some people have genetics that make them more leptin sensitive, they are genetically prone to higher levels of inflammation.  They need more Omega III or Vitamin D.

 

We all need personalized intervention!

 

DNAFIT

 

A Core Ingredient for Weight Loss

 

By Dr. Nancy J. Miller-Ihli

Successful weight loss requires that we address inflammation, satiety, and metabolic challenges.  Leptin is a hormone that plays a key role in regulating energy intake and energy expenditure, including appetite/hunger and metabolism. Overweight individuals have elevated leptin levels yet are resistant to the normal effects of leptin.

LeptiCore – a patent-pending nutraceutical complex of plant-based polysaccharides, esterified fatty acids, pomegranate extract, beta-carotene, and more – has been clinically shown to reduce leptin levels as well as systemic inflammation.  The result is enhanced leptin function which means people feel full sooner (improved satiety), their metabolism is more efficient (improved thermogenesis,) and they have good blood sugar control allowing them to achieve and maintain a healthy weight.

LeptiCore is also formulated with blue-green algae, which contains phenylethylamine (PEA) known to enhance mood by raising serotonin levels. This is an important element for weight loss, as improved mood has been shown to help individuals avoid stress-eating.

As a scientist and health professional, I always want to back up my nutritional recommendations with hard facts. And the studies done on LeptiCore are very exciting.

For example, a recent eight-week study* published in the journal Lipids in Health and Disease highlighted LeptiCore’s weight management and metabolic wellness benefits. This study found that taking 600 mg of LeptiCore daily decreased body weight, body fat, waist and hip circumference, lowered leptin and c-reactive protein levels, and improved blood sugar balance, blood lipid profiles and serotonin levels.

 

 Lepticore

 

It is excellent that body fat was monitored in the study, because it showed fat was lost rather than muscle or water.  Also, reducing body fat – particularly in the abdomen, as shown by decreased weight and hip measurements – significantly reduces health risks.

One more thing: in this study, participants achieved these great results WITHOUT modifying their food choices.  Just imagine what can be achieved when LeptiCore is combined with a healthy, low-glycemic eating program and proper exercise.  The results can be outstanding!

Studies like this show that LeptiCore offers great support to individuals who want to lose weight, and improve their body composition and cardiovascular health. In my opinion, LeptiCore is much more than a weight loss ingredient. It is really a wellness ingredient because it can positively impact so many aspects of health.

 

*Source: Kuate et al, The use of LeptiCore in Reducing Fat Gain and Managing Weight Loss in Patients with Metabolic Syndrome, Lipids in Health and Diseases (2010) 9:20

Nancy Miller-Ihli, PhD, is a former USDA National Program Leader for Nutrition and is a guest member of the nutraMetrix clinical faculty.  She is the senior author of more than 70 peer-reviewed publications and has authored a white paper on obesity for the White House.  Dr. Miller-Ihli is a strong proponent of low-glycemic impact eating as part of a healthy lifestyle and is committed to community-based nutrition education.

 


Nutrition, Environment & Genetics Taking Control of your Health

GenePuzzle

I want YOU to join us for this unique, cutting edge approach!!!

May 2nd, 2015 1:30 – 3:30  Princeton, New Jersey

 

It is not as easy as it used to be: foods are genetically altered, the environment is polluted…Genetics is like a loaded gun & environment is the trigger.

 

My Dad died at a very young age of a massive heart attack, I’ve had very close calls at least three times because of interactions to medication, and thirteen of my friends have died from breast cancer.  I’m the only sixty something I know that isn’t on some prescription for something.

– Kathy

In the past 2.5 years, I lost my brother in a car accident, our mother had a stroke, and our Dad’s Rheumatoid Arthritis and Lung Disease have worsened.

– Dr. Mary Boname

 

 We do not want biology to be destiny. We took control & you can too.

 

When certain parts of the human genome are turned off or on, this can manifest as disease–poor digestion, detoxification, autism, birth defects, anxiety, depression, diabetes, cancer, and the list goes on and on.

 

Lifestyle factors–food, exercise, stress, toxins, environment, and sleep–are the epigenetic control levers. The research and science shows this without a doubt.

 

The good news is you have CONTROL over most of these factors. We can work together to achieve optimal health.

 

Dr. Mary Boname of Montgomery Eye Care invites you to come learn how you can influence genetic expression!

 

Dr. McKenzie has been a practicing pediatrician in the Boston area for over 30 years!

 

Meet fellow health professionals and community members who are looking for information and solutions.

RSVP Kathy Kaufman

 

Kathy.kaufman@gmail.com 617 515-7559


Holiday Greetings

Christmas

You are goodness and mercy and compassion and understanding.

You are peace and joy and light,

You are forgiveness and patience, strength and courage,

A helper in time of need, a comforter in time of sorrow,

A healer in time of injury,

And a teacher in times of confusion,

You are the deepest wisdom and the highest truth,

The greatest truth and the grandest love

You are these things and at moments in your life you have known

Yourself as these things

Choose now to know yourself as these things always

 

MERRY CHRISTMAS


The Four Nutraceutical Ingredients Everyone Should Look at for Fitness

By Kerri Whatley

 

Everyone is trying to get healthy and fit and while doing so, your body needs extra vitamins and nutrients. It is simple really, you can’t deplete something without having to replenish it. The same goes for your body. Sometimes our bodies aren’t getting enough of what it needs to begin with, and that could start the “get fit” process off on the wrong foot.

1) Branched Chain Amino Acids that have anabolic effects on protein metabolism by raising the rate of protein synthesis and lowering the rate of protein degradation in resting human muscle. Also, during recovery from endurance exercise, BCAAs were found to have anabolic effects in human muscle.

A study published in the National Institute of Health showed “When BCAAs were supplied to subjects during and after one session of quadriceps muscle resistance exercise, an increase in mTOR, p70 S6 kinase, and S6 phosphorylation was found in the recovery period after the exercise with no effect of BCAAs on Akt or glycogen synthase kinase 3 (GSK-3) phosphorylation. Exercise without BCAA intake led to a partial phosphorylation of p70 S6 kinase without activating the enzyme, a decrease in Akt phosphorylation, and no change in GSK-3.”These findings show that the Branched Chain Amino Acids help with the recovery of the human muscle after a workout

 

2) Pine Bark, also known as Pycnogenol, has been shown to help with cramps and muscle pain before during and after a workout. A study found in the U.S. National Medical Librarywas done to assess the prevention of cramps and muscular pain with the use of Pycnogenol. The study was done over a 9 week period (5 weeks of activity with Pycnogenol and 4 without) to study the effects Pycnogenol plays on the body. Research suggests that the use of Pycnogenol prevents cramps, muscular pain at rest, as well as pain after or during exercise.

Stated in the report, “The difference is statistically significant considering objective observations (cramps episodes) and evaluating more subjective aspects (score). This indicates that Pycnogenol is effective in reducing pain and cramps during retraining and rehabilitation increasing its efficiency. In starting any physical rehabilitation program, particularly in vascular subjects, the limitation in mobility associated with muscular pain and with cramps tends to be relevant, and controlling these symptoms is useful to speed up the retraining process.”

3) While trying to achieve the most from your work out you can add activated B vitamins to help give you the energy you need. By using these advanced forms, the body has to work less for utilization and effectiveness is increased. Folinic acid, 5-MTHF, methylcobalamin (B12) and pyridoxal 5’ phosphate (B6) is known to promote cardiovascular health. Additional B vitamins such as B1, B5, niacin and biotin support many processes allowing this product to work via several mechanisms to increase energy, promote cardiovascular health, decrease stress and improve mood while helping to maintain normal serotonin levels.

Vitamin B12 also takes part in metabolism, along with the other B vitamins. The vitamin helps our bodies convert the food we eat and turn it into the energy we need. The B vitamins also help the body digest proteins and fats. This helps your body use the food you eat more efficiently as fuel.

4) While working out is great if your bones can’t handle the activity, you won’t get very far. Vitamin D promotes the efficient intestinal absorption of calcium, by supporting the synthesis of calcium-binding proteins to promote normal calcium absorption and retention. Vitamin D also promotes the normal formation of bone and normal bone growth, and bone remodeling by osteoblasts and osteoclasts. Daily supplements of vitamin D3 may improve certain markers of heart health like HDL cholesterol, and lead to significant reductions in body fat mass in overweight and obese people, says a new study posted in the British Journal of Nutrition.


Methylation – Notes from the Cutting Edge

Methylation ….

Turn genes on and off

Process chemicals and toxins (biotransformation)

Build neurotransmitters (dopamine, serotonin, epinephrine)

Process hormones (estrogen)

Build immune cells (T cells )

DNA and RNA synthesis

Produce energy (CoQ10, ATP, carnitine)

Produce protective coating on nerves

Methylation can be disrupted by

Lack of cofactors driving methylation forward (zinc, magnesium, B6 )

Medications (antacids)

Specific nutrients depleting methyl groups (niacin)

Environmental toxicity, heavy metals, chemicals (acetylaldehyde, arsenic, mercury)

Excessive substrate (Feedback inhibition; too much cysteine, SAMe, glutathione)

Genetic mutations

Prevalent Conditions

 

Diabetes Fibromyalgia
Cancer Chronic Fatigue Syndrome
Pulmonary Embolisms Depression
Cleft Palate Alcoholism
Spina Bifida Addictive Behaviors
Autism Insomnia
Parkinson’s Down’s syndrome
Atherosclerosis Chronic Viral Infection
Neural Tube Defects Thyroid Dysfunction
Immune deficiency Neuropathy
ADD/ADHD Recurrent Miscarriages
Multiple Sclerosis Infertility
Alzheimer’s Anxiety
Dementia Schizophrenia
Chemical Sensitivity Bipolar
Congentital Heart Defects Allergies

 

Contributors

Industrialized farming and ranching (poor nutrition, chemical exposure)

Increased stressors (longer work hours, less sleep, more demands, faster society, technology, digital dementia)

Pervasive chemicals (school, work, food, water, air, soil, products)

Standardized healthcare (symptomatic treatment vs understanding underlying causes)

Lack of education: unaware of common everyday harmful exposures

Lobbyists (protecting big business)

Treatment

Balance Methylation

Multifaceted approach: The Basic Five

lifestyle, diet, environment, mental outlook, nutrition

The approach is demanding, requires patient education, is difficult to achieve,

Hard to maintain and takes time BUT

It is required and sometimes it is still not enough

GENETICS IS THE MISSING FACTOR IN UNDERSTANDING UNDERLYING CAUSES OF DECREASED METHYLATION

Test for MTHFR – C677T and A1298C

Still not improving?

MTR/MTRR – recycles B12 and processes B12 for methionine production

GSTM1 and SOD – major detoxification enzymes

CBS – processes homocysteine and if upregulated depletes methyl groups

Increases taurine

NOS – processes ammonia, forms nitric oxide from argenine

COMT and MAO A – processes and neurotransmitter catabolism and estrogens

GAD – transforms glutamate into GABA

HNMT- processes histamine (secondary enzyme for histamine – primary is DAO)

QDPR – recycles BH4

SUOX – processes sulfites/sulphur, and this mutation is made worse from CBS

upregulation; people with this may get worse when they detox as sulfur by

products are prominent during detox

 

Who Should be Screened?

 

Diabetes Fibromyalgia PreConception
Cancer Chronic Fatigue Syndrome Newborn
Pulmonary Embolisms Mental Health Syndromes Cervical Dysplasia
Cleft Palate Alcoholism Birth Defects
Spina Bifida Addictive Behaviors Drug/supplement Sensitivities
Autism Insomnia Chronic Pain
Parkinson’s Down’s syndrome Elevated histamine
Atherosclerosis Chronic Viral Infection Elevated Cobalamin
Dementia Thyroid Dysfunction Congentital Heart Defects
Immune deficiency Neuropathy Allergies
ADD/ADHD Recurrent Miscarriages Chemical Sensitivity
Multiple Sclerosis Infertility Bipolar
Alzheimer’s Anxiety Schizophrenia

 

Test Everyone

 

Prevalence

 

 

Group One C677T Variant Two C677T Variants One C282Y and One A1298C Variants Two a1298CVariants
Caucasian 25 – 45% 8 – 18% 15 – 20% 4 – 12%
Hispanic US 42% 21% Not known 25%
Black US 14% 1% Not known 2 – 4%
Asian 35% (Japanese 11% (Japanese) Not known 1 – 4%

 

Having two MTHFR  variants is more common than having high homosysteine or any condition linked to high homosysteine.  Atlantic Health. Dnadirect

Learn more at MTHFR.net

 

 

 

 


Happy New Year 2014

 

What have we learned?

“Scientists now see inheritance as more fluid, and the barriers between genes and the environment as more porous.

It’s not all about the genes anymore; it’s about expressing genes, or turning them on and off.  Cells commonly turn DNA off by dotting it with small bumps called methyl groups, or turn DNA on by using acetyl groups to uncoil it from protein spools. ( Read more)

We have changed the climate.

The air is warming and the excess moisture is contributing to more severe weather.

The oceans are becoming more acidic.

We’ve industrialized food.  Grassroots local food movements have sprung up but the incentives are built in for big corporate farming.

Because of the industrialization of food and premature harvesting most food is lacking in minerals and enzymes.  Because of the incentives junk food is cheap.

There is a diabetes epidemic.  The US is the second fattest country in the world.  Mexico is number one.

Coal burning plants used for our electrical grid produce a by-product of methyl mercury.  Methyl mercury is found in high quantities in the ocean (along with other toxins) and is also now being found in root vegetables.

Fracking from gas extraction results in flowback and produced water containing sodium, magnesium, iron, barium, strontium, manganese, methanol, chloride, sulfate, benzene, toluene, ethylbenzene, xylene and natural radioactive substances.

Aside from the by-products of fossil fuels we haven’t seen any dinosaurs lately so sustainable energy has become a priority – at least in other parts of the world.  Germany has more than 300,000 solar homes and it is not a sunny country.

I live in a solar home and it didn’t cost any more to build than one that isn’t.  When storms took out the grid, I still had power. Companies like Solar City, a Google backed company can provide the solar systems without the upfront expense.

There are wind and solar companies now that can provide electricity for the grid.

We have polluted the environment with pesticides, chemicals, drugs, genetically modified organisms including inserting BT toxin into the DNA of food which is showing up in the digestive tract of newborns according to clinical studies in the UK.

We have discovered patients are different.  Their genetics are different.  A one size fits all approach to health does not make sense anymore.

There are MDs curing so called “incurable” diseases by running the human genome and treating the patient based on their genetics.  A doctor in Texas has been doing this for ten years but his treatment does not fit the approval process of the FDA because it is personalized.

There are medical devices now that can help prevent adverse cardiac events ten years in advance.

There are MDs using these devices to prevent issues by helping patients make lifestyle changes to support their genetics.

I do not have the symptoms of inflammatory diseases that I had previously because ten years ago I did a genetic screening, changed my lifestyle and cleaned up my environment.

Despite overwhelming scientific evidence there is still a fundamental disconnect between medical and nutritional mindsets and flawed studies on both sides.

The US pays the highest healthcare costs in the Western World.

The costs of clinical studies are exorbitant.

A gene can be patented but a natural substance cannot.

Experts wouldn’t expect a pill to have the same impact as an IV. They know all versions of drugs aren’t as effective.  Some create worse side effects than others.

However supplements and nutraceuticals are all lumped together.  Most MDs tell their patients to just go anywhere to get them.

The FDA does monitor them but not the way they monitor pharmaceuticals and that is because they usually don’t kill people.

I’ve seen clinical studies on an isotonic solution compared to the same exact powder compressed in a pill form.  The difference in results is dramatic.  And I expect if anyone bothered to study it, there would be differences based on genetics.

This would be true of pharmaceuticals and nutraceuticals.  Some individuals benefit, some could be harmed and some have no impact at all depending on their genetics.

 

Some Interesting facts supported by science based studies:

40% of Americans have the MTHFR Gene SNP

Folic Acid fortification may be causing an increase of MTHFR defects

MTHFR can be related to birth defects and many disease symptoms

47% of Americans take at least 1 prescription drug each month

Close to 100% of prescription drugs deplete some component of B complex

Once a patient is taking 2 prescription drugs, they are likely to be put on an antidepressant

Host resistance and susceptibility to influenza depend importantly on the ratio of vitamin D to vitamin A activity

A 25-hydroxy serum level of 55 is needed to prevent the flu

Researchers have shown that vitamin D status is associated with the immune system, the production of cytokines and chemokine signaling.

Resveratrol can activate the SIRT1 gene.  This has only previously been demonstrated with caloric restriction.

Gene SNPS that have been clinically shown to be involved in weight management and express or not based on lifestyle i.e. the patients can impact these by their lifestyle choices: ACE, ADRB2, PPARGC1A, CRP, IL6, TNFalfa, ENOS.

New clinical studies on weight management will be implemented into genetic screenings this year.

By 2015 the area of nutrigenomics will have exploded dramatically.

Patients are extremely interested in preventing disease as demonstrated by their buying decisions.

The ACA (Affordable Care Act) is now law. Incentives for prevention are built in for health professionals and for patients.

Most health professionals have no business training but many are running a business.

The question is will health professionals become healers and help their patients with this quest or continue down antiquated paths that are demonstrating abominable results and leave their patients to make poor decisions based on marketing alone.

Some health professionals will learn to understand the concept of leverage, the missing ingredient in most Americans lives.  Some will be forced into being hospital employees or employees of other kinds of medical corporations or go broke.

This will be a breakthrough year for some health professionals.  They will change their own health, the health of their patients and they will turn their occupation into an avocation because they will have their time back.


METHYLS and ACETYLS; You gotta lot of splainin to do

Ehyl and Lucy

“Scientists now see inheritance as more fluid, and the barriers between genes and the environment as more porous.

It’s not all about the genes anymore; it’s about expressing genes, or turning them on and off.  Cells commonly turn DNA off by dotting it with small bumps called methyl groups, or turn DNA on by using acetyl groups to uncoil it from protein spools.

And scientists now know that cells pass those precise patterns of methyls and acetyls on to daughter cells whenever they divide – a sort of “cellular memory.”  (Indeed, scientists once thought that the methyls in neurons physically recorded memories in our brains.  That’s not right, but interfering with methyls and acetyls can interfere with forming memories.)

The key point is that these patterns, while mostly stable, are not permanent: certain environmental experiences can add or subtract methyls and acetyls, changing those patterns.  In effect this etches a memory of what the organism was doing or experiencing into its cells.

Unfortunately, bad experiences can be etched into cells as easily as good experiences.  Intense emotional pain can sometimes flood the mammal brain with neurochemicals that tack methyl groups where they shouldn’t be.

Mice that are (however contradictory this sounds) bullied by other mice when they’re pups often have these funny methyl patterns in their brains.  As do baby mice (both foster and biological) raised by neglectful mothers, mothers who refuse to lick and cuddle and nurse.

These neglected mice fall apart in stressful situations as adults, and their meltdowns can’t be the result of poor genes, since biological and foster children end up equally histrionic.  Instead the aberrant methyl patterns were imprinted early on, and as neurons kept dividing and the brain kept growing, these patterns perpetuated themselves.  The events of September 11, 2001, might have scarred the brains of unborn humans in similar ways.  Some pregnant women in Manhattan developed post-traumatic stress disorder, which can epigenetically activate and deactivate at least a dozen genes, including brain genes.

These women, especially the ones affected during the third trimester, ended up having children who felt more anxiety and acute distress than other children when confronted with strange stimuli.

Notice that these DNA changes aren’t genetic, because the A-C-G-T string remains the same throughout.

But epigenetic changes are de facto mutations; genes might as well not function.  And just like mutations, epigenetic changes live on in cells and their descendants.  Indeed, each of us accumulates more and more unique epigenetic changes as we age.  This explains why the personalities and even physiognomies of identical twins, despite identical DNA, grow more distinct each year.  It also means that that detective-story trope of one twin committing a murder and both getting away with it – because DNA tests can’t tell them apart – might not hold up forever.  Their epigenomes could condemn them.

Of course, all of this evidence proves only that body cells can record environmental cues and pass them on to other body cells, a limited form of inheritance.  Normally when sperm and egg unite, embryos erase this epigenetic information – allowing you to become you, unencumbered by what your parents did.  But other evidence suggests that some epigenetic changes, through mistakes or subterfuge, sometimes get smuggled along to new generations of pups, cubs, chicks, or children.”

From THE VIOLINIST’S THUMB by Sam Kean

 

 


Genetics and Vitamin D (VDR)

If you Google VDR you’ll usually get hits for Video Disk Recorder but in the health arena VDR (Vitamin D Receptor)  is a powerful gene that encodes the nuclear hormone receptor for Vitamin D3.

This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II Vitamin D-resistant rickets.

It is a key nuclear receptor that binds nutritionally derived ligands and exerts bioeffects that contribute to bone mineral homeostasis, detoxification of exogenous and endogenous compounds, cancer prevention, and mammalian hair cycling. Liganded VDR modulates gene expression via heterodimerization with the retinoid X receptor and recruitment of coactivators or corepressors. VDR interacts with the corepressor hairless (Hr) to control hair cycling, an action independent of the endocrine VDR ligand, 1,25-dihydroxyVitamin D(3).
There is much spin doctoring on the Internet mostly for marketing purposes. I confess I market as well but do my best to be science based. Unfortunately all the marketing can mask real evidence and lead to skepticism.

There is always the crowd who promotes au naturel and insists you can get all your Vitamin D from sunlight and diet.  They clearly do not live in New England or the Northern hemispheres or parts of the planet that are dark for 6 months.

At one time in the earth’s history before polluted environments and industrialized food it may have been true.

But now there is so much dismaying information about the state of the oceans, environment and climate, food farming along with just plain old personal hygiene information I have a hard time believing we can do it anymore.  If you are in the U.S. north of Atlanta or have the mutation, VDR, I recommend supplementation.

In March of 2017 news came out that 100,000 Canadians have MS, the highest rate in the world.  They are 28% higher than the country with the second highest numbers of MS, Denmark.  Speculation is part of the problem is Vitamin D deficiency.

A pediatrician I work with did quite a bit of research on Vitamin D and said to get enough from the sunlight it would have to stay on your skin for about 24 hours to be converted.
I doubt there are many of us who don’t bathe for that long a period.  There are other skin specialists who say after a few minutes of exposure it is detrimental to your Vitamin D levels.  And then there is the possibility that prolonged exposure to UVR is linked to skin cancer.

Senator Whitehouse of RI did a speech on the state of the ocean and said when a whale beaches up on RI shores; it is considered toxic waste so unless you want a healthy dose of toxic waste in your diet, seafood is a bit risky these days.  I’ve had food poisoning twice from tuna and sadly have now given it up.

Impaired intestinal absorption and reduced metabolism to active forms of Vitamin D are contributing to deficiencies.

We know that genetics are not cast in stone anymore and some genes can be expressed or not based on lifestyle and environment.  Some studies have shown that low levels of Vitamin D in people with autoimmune diseases are not from deficiency but from chronic infections of bacteria that down regulate the Vitamin D metabolism.

These people have been treated with antibiotics which can be problematic as bacteria are very good at mutating and becoming resistant.  And who knows maybe years of over treatment with medications contributed to this problem in the first place?  Some of the sickest people I know who have auto immune diseases have been on the most meds during their lifetime. I personally know two people with Stevens Johnson’s Syndrome who have probably been on twenty times the pharmaceuticals and over the counter meds in their life than I have and they never really had serious conditions that required them.

More than 50% of postmenopausal women taking medication for osteoporosis have suboptimal levels of Vitamin D.

The magnitude and direction of the association between obesity and the risk of vascular calcification may depend on an individual’s 25(OH)D level.

Environmental toxins like herbicides can contribute to the down regulation of vitamin D.

This year a team of academic researchers pinpointed how Vitamin D3 and omega-3 fatty acids may enhance the immune system’s ability to clear the brain of amyloid plaques, one of the hallmarks of Alzheimer’s disease.

Johns Hopkins did this study. Patients with low Vitamin D levels were significantly more likely to develop a condition called recurrent inflammatory spinal cord disease. The researchers considered this finding to strengthen the evidence base of an existent link between low Vitamin D levels and immunologic dysregulation.
Vitamin D3 supports the synthesis of calcium-binding proteins.

Without adequate amounts only 1–15% of dietary calcium is absorbed which is critical in the normal formation of bone and normal bone growth and bone remodeling by osteoblasts and osteoclasts. It promotes regulation of T-cell function and through its interaction with VDR it supports the healthy expression of the gene to maintain healthy blood pressure.

K2 in combination with D3 ensures transport to the bones and blood vessels. Only 10% of dietary Vitamin K is in K2 form so it is not easy to get from food.  And increased Vitamin D3 uses up K2 in the body so it makes sense to have them together. In addition novel dietary ligands for VDR like curcumin, gamma-tocotrienol, and essential fatty acid derivatives likely play a role in the bioactions of VDR.

It does matter when it comes to how to get this additional supplementation into the body.  Some products have rancid oil in them leading to UTIs (Urinary Tract Infections).

IV is the optimal form of delivery to the body so anything that is designed to mimic that and has the science to prove it should be of interest to health professionals.
Recently I’ve met so many more professionals who are taking the time to learn the science to advise their patients but they drop the ball when it comes to where the patient should get the solution.

The FDA does not monitor the industry so professionals really need to be educated when they advise patients.

Just go to Amazon or CVS is what patients tell me they were advised to do. There are 3,469 choices on Amazon.

This is like the dilemma I used to experience in the supermarket when my children were little and I was in the cereal aisle. It was a little easier with cereals.  I told my son anything with less than 5 sugars which served to educate him on all the different kinds of sugars and served me as I knew the only one would be Cheerios.

And I could use them for toilet training.  Shoot for the center I told my son.

Unfortunately, I don’t think we want to play games with nutrition. I played the shotgun approach for 40 years wishing my doctors could advise me and just tell me the good one. I probably took many things I didn’t need and wasted my money because it wasn’t getting into my system.  When  patients are surveyed many express they feel this way.

Three elderly patients told me they were instructed by their doctors not to take Vitamin D3 because it contained Vitamin K.  I’m guessing their doctors were thinking of Vitamin K1 which is concentrated primarily in the liver and at high doses may interfere with anticoagulant medications.

But the fact that some doctors were unaware of the difference in the two K Vitamins compounded by the fact that lack of patent incentives means a dearth of  scientific evidence in the US is a case for more preventive education in medical school and in continuing medical education where the education is now heavily weighted towards the pharmaceutical industry that is rewarded by patents.

When we move into the Fall/Winter season the evidence of adequate intake of not just Vitamin D3 with K2 but all essential nutrients in preventing viruses and upper respiratory infections is important, especially for children and the elderly. If we can’t make it we need to take it.

The future is very exciting.  The research is moving at a fast pace due to the resurgence of rickets and the prevalence of autoimmune disease.

We don’t have to keep playing the shotgun approach. We can take the scientific approach.  I start with this lifestyle genetic screening.

Notice it tells me I need additional Vitamin D.  That is because I have the VDR mutation.

This does NOT have to express.  None of the genes in this screening necessarily will express.  Whether they do or not depends on my lifestyle, environment, the choices I make.

Changing my lifestyle has had these impacts on my  health:

I don’t get sick much

I’m fit

My skin and hair look great

I have offset many pro-inflammatory conditions by taking a scientific approach.

 

I recommend this isotonic Vitamin D3 with K2.  To learn more about affordable, scientific genetic screenings contact me. Kathy@criticalhealth.org.

30% Lower Risk of Cancer with 3 times the RDA of VitaminD3 – 4 year Clinical Study

 


TNFα, The Good, The Bad and The Ugly

TNFαTumor necrosis factor alpha

The last newsletter I wrote about a recent event that happened to me.  I developed an abscess next to my appendix and my immune system walled it off, saving me from surgery and possibly saving my life.

Over the years I have noticed that I have tendencies towards infection.  When I was three years old I got the mumps and they abscessed.  When I would have work done on my teeth, I would get an abscess.  I got an infection after the birth of my daughter and became septic and now this recent abscess.

I have the Gene SNP TNFα (tumor necrosis factor-alpha.)

I’ve been fortunate to know a very famous genetic scientist who helps develop genetic screenings, Dr. Keith Grimaldi.   I’m not a doctor myself nor am I a scientist but I love to learn about science especially genetics.  Dr. Grimaldi has explained to me that many Gene SNPs have a benefit as well as a detriment.

Some genes, including TNFα, can be impacted by our lifestyle.

He has also explained that in instances like TNFα if the recommended lifestyle changes are not made we will not get the benefits of the gene expression nor will we offset the detriments.

Of course this is just a guess but in the case of the abscess recently it may have been a benefit to have this variant.

Tumor necrosis is involved in the immune response to bacterial, viral, and parasitic invasions.   It is also an acute phase protein that initiates a cascade of cytokines and increases vascular permeability, thereby recruiting macrophages and neutrophils to a site of infection.

TNFα is a proinflammatory cytokine produced in many inflammatory and autoimmune diseases such as rheumatoid arthritis, Crohn’s disease, multiple sclerosis, or chronic hepatitis C.

It is produced by different cell types including macrophages, monocytes, T-cells, smooth muscle cells, adipocytes, and fibroblasts. This cytokine is also implicated in the diseases of the central nervous system like Alzheimer’s and Parkinson’s diseases, where it can be produced by several cell populations, including microglia, astrocytes, endothelial cells, Th1 lymphocytes and neurons.

TNFα can have pathological consequences such as promoting the growth of some tumor cell types. It also plays an important role in the chronic inflammation that occurs in various pathologies and has been identified as the major mediator in various autoimmune diseases.  TNFα thus represents a good marker of inflammatory events.

 

Endothelial dysfunction is an early indicator of cardiovascular diseases, including that seen in type 2 diabetes. Accumulating evidence suggests that mediators of inflammation may be pathogenic by inducing vascular dysfunction. Among the various inflammatory factors, TNFα  plays a pivotal role in the regulation of vascular function in various pathological status .

It can either exist in a membrane-bound form or be secreted as a soluble cytokine that is able to diffuse from the sites of its initial production . It can bind to, and thus functions through its receptors, TNF receptor type 1 (TNFR1) and TNF receptor type 2 (TNFR2).

Dietary supplements and exercise are emerging as effective adjunctive therapies targeting endothelial dysfunction and vascular wall inflammation. This review summarized the vasoprotective effects of dietary supplements and exercises by inhibiting TNFα production and TNFα-induced signaling (Figures 1 and 2).

 
Figure 1: Dietary supplements (fish oil, dietary fiber, and various flavonoid and nonflavonoid natural products) exert vasoprotective benefits by inhibiting TNFα production and its downstream signaling pathways. There are dichotomies in the effects of exercise training on TNFα production. Whereas acute exercise has been reported to increase the production of proinflammatory cytokines, chronic exercise reduces TNFα levels.  Thanks to Hindawi.com

 

 
Figure 2: Multiple mechanisms are involved in the vasoprotective effects of dietary supplements and exercise by inhibiting TNFα signaling.  Thanks to www.Hindawi.com

 

More information:

TNFA curcumin

Curcumin Protects Neuron against Cerebral Ischemia

 

Curcumin induced apoptosis or necrosis of macrophages

 

Curcumin Protects against UVB-Induced Skin Cancers

 

TNFA eye health

 

TNFA Omegas

Vasoprotection of Omegas

 

TNFA Resveratrol

Vasoprotection of resveratrol

Neuroprotective effects of resveratrol

Protective effects of resveratrol on cytotoxicity

 

If you’d like to purchase high quality nutraceuticals from an excellent certified health provider.