INFLAMMATION – hot hot hot

Inflammation photo

 

The secret to a quality of health and well-being?

It’s not vitamins, growth hormone, emotional cleansing, detox, meditation, yoga, tender loving care (TLC) or even exercise. They all help, of course they do!

But it’s pretty clear to doctors who know their stuff what the number one factor is: you need to keep inflammation to an absolute minimum.

Inflammation is an insidious disease process that goes on in all tissues and organs and greatly accelerates change and decay.

Relaxed and efficient tissues and organs perform well but when they are hot and excited, suffering from a cascade of irritating painful chemicals known as inflammatory cytokines (everything quickly starts to break down and the aging process advances rapidly.)

Most of the diseases which are hallmarks of decay and aging have a strong inflammatory component. Cancer, heart disease, arthritis, arteriosclerosis, Alzheimer’s disease and diabetes (yes, you read those last two right)… these are all, essentially, inflammatory diseases.

Inflammation can be caused by allergies, parasites, intolerant substances, chemical pollutants, electrical and magnetic field burdens, microbes (especially hidden chronic infections) and a host of other factors.

And inflammation is cooled down by important nutrients like science based quality omega-3 fatty acids and antioxidants. Now you know why they work!

So What Can We Do?

Reduce the inflammatory load.

There is one very easy and amazingly successful way to do this. You can do it.

If you do it right you’ll look and feel years younger within a matter of months. People will say: “What are you on? I want some!” and You’ll look ten years younger. What is your secret?”

What’s the Big Secret?

It’s eliminating stressor or inflammatory epigenetics (diet, lifestyle, and chemical exposures, environment and how they impact your genes possibly your children and grandchildren).

Now this is NOT the same story as eating right for your type, the blood group diet, food combining or acid vs. alkaline foods, plant based, vegan OR ANY OTHER DIET “THEORY” although many of those matter too but YOU are unique.  This is about your genetics and your environment and using science-based solutions not marketing based-solutions.

This is about working out your own personal UNIQUE anti-inflammatory lifestyle based on YOUR genetics.

 How Can I Find Out My Genetics?

The Human Genome Project, a $3-billion project was formally founded in 1990 by the US Department of Energy and the National Institutes of Health and from that the world has changed.  The future is genetics and it is moving like a rocket ship.

Lots of people are buying genetic kits like 23AndMe, Ancestry.com, and every day new companies come to market to get a piece of this amazing pie.  Most of them do it so they can use your DNA for clinical studies.  There is nothing wrong with that and we need that but seriously why don’t they just pay you for it?

Sure they give you information BUT if you believe it won’t get into the hands of insurance companies and others who will discriminate against you (and yeah I know it is against the law) but seriously if you believe the law will protect you, I have a bridge I can sell you in Brooklyn.  You need to make sure the kit you buy is science based and they destroy your DNA without selling it to anyone.

I like to work with a genetic scientist named Keith Grimaldi who worked with Dr. Walter Gilbert, Nobel Laureate in DNA on the Human Genome Project and helped to develop the first lifestyle screening.  For as long as I’ve known him, which is since 2005, he has the highest integrity and so do the companies he works with. He won’t put a genetic SNP in his screening unless he has the science – 3 independent clinical studies proving if you change your lifestyle, you can change the expression of your DNA.

In all fairness, that’s just not true for other companies.  They put SNPs in without that kind of scientific verification.

It is the FDA’s job to monitor that but honestly, they just can’t keep up so these days we all have to be our own grassroots activist.

Your doctor most likely won’t even have any training on this unless your doctor makes it a priority (but there are health professionals who do make it a priority).

Most doctors are just keeping their head above water.  (In the U.S. they still don’t even tell their patients to take CoQ10 when they give them a statin even though it is in the literature and they’ve been packaging it together for over a decade in Europe.  That one is for you Dave.)

So Now I know My Genetics, What is a SNP (single nucleotide polymorphism)?

What is SNP

All of us have small differences in the information that our DNA contains, and it’s these differences that make each of us unique. Gene polymorphisms are slight changes in the genetic code that are present in at least one percent of the population or as much as 50% or more.

For example – one genetic “letter” (A, T, C, or G) may be replaced by another. These polymorphisms can lead to different processes in the body, just as altering one letter in a word can completely change its meaning, like MAP or MOP.  Those are very different meanings. When the change affects only one genetic letter, it is called a “single nucleotide polymorphism” (or SNP, pronounced “snip”).

 

What Are the Genetic SNPs related to Inflammation?

There are lots but remember we are looking at the ones that we KNOW you can change by changing your lifestyle.

Inflammation SNPs

What Can I DO?

Change your lifestyle and environment.  Start with what you eat.  You need to eat organic, mostly plant based and you need meat and eggs in my opinion.  Cut out simple carbs and eat less grains but this will all be different for different people; based on their genetics.

DNAFIT

Environment

Eliminate all processed foods that contain synthetic folic acid.  Eat Organic.  Avoid any unnecessary toxins to offset expression of SOD2 and other genes.

Eliminate flour, grains as much as possible.  Sometimes it is OK but there are genes that put you at risk for celiac problems.

Eliminate endocrine disruptors.  Replace plastics with glass.  Replace Teflon pans with stainless steel and other non-toxic substances. Install a whole house water filter.

Yeah I know it isn’t easy but at the risk of exposing my age my childhood had NONE of that stuff.

Exercise

Regular exercise makes your body release endorphins, which help to reduce pain and make you feel much better. So much so that exercise is now being used as a treatment for depression in some places.
Diet
In my case a low carbohydrate diet is recommended because of my very high genetic sensitivity to carbs. Managing weight is important.
Overweight is a “pro-inflammatory” condition.  I’m a big fan of lifestyle changes NOT diets.  A diet by its very definition won’t work because you go “on” and “off.”  If you don’t change lifestyle, you will gain the weight back when you stop dieting.  And yo yo dieting is the worst thing you can do for cardiovascular health.  Transitions Lifestyle System, TLS has every component demonstrated through science that helps people reach their ideal weight and most importantly, STAY THERE. It is realistic as it has a quiz built in asking the individual their goals and what they are willing to do and then recommending a plan they can stick to.

Supplementation

Everyone MUST supplement.  Dr. Mark Hyman says it best, “Maybe if we eat only wild, fresh, organic, local, non-genetically modified food grown in virgin, mineral and nutrient-rich soil that has not been transported across vast distances and stored for months before being eaten……AND work and live outside, breathe only fresh unpolluted air, drink only pure clean water, sleep nine hours per night, move the body every day, are free from chronic stressors and exposure to environmental toxins, then perhaps we might not need supplements.”

We still burn coal for energy and the by-product of burning coal is methyl-mercury.  We breathe it, it goes into our soil when it rains and it impacts (especially) root vegetables.  It goes into our water systems and impacts everything in those systems that we consume.

We’ve polluted our air, water and soil with herbicides, pesticides, chemicals and pharmaceuticals.  For example a kind of plastic, BPA will cause an increase in blood pressure.  There is almost 300,000 tons of it in the ocean alone.  We use plastics for everything now.  We should stop using plastics and Teflon coated items for food preparation and storage.

Getting Nutrition Into Your Cells

The study below shows a nutrient in two different forms. The maroon color is the nutrient in an isotonic delivery (similar to an IV with the appropriate salts and sugars added to get the ingredients to the cells asap).

The orange color is the exact same nutrient powder crushed into a tablet.  I think the table speaks for itself.

The delivery system matters.  It matters for bioavailability and it matters for speed.  And if you have genetic snps related to your digestive tract it’s even more important.

Isotonic_clinicalstudy

Omega III

It is not safe to eat fish high in fat; maybe Wild Alaskan Salmon (but then you have to deal with issues like the retailers are mislabeling so they can charge more money and regulators can’t keep up). Senator Whitehouse of RI gave a speech on the state of the oceans.  His wife is a marine biologist for the Obama Administration.  In the speech he said that the ocean is toxic.  He said when a whale beaches up on the shores of RI it is considered toxic waste.  The other problem is there is tons of plastic in the ocean.  Plastic can cause high blood pressure and other problems if consumed.  It is an endocrine disruptor. The fish are eating the plastic and tiny bits of it are showing up in their bodies and then you eat them.

Because it is critical to consume fatty-ocean products, Omega III are an alternative.  You can learn more here. It’s also critical we clean up the ocean and stop polluting it.

Omega III is a very important nutritional product for everyone. Not all Omega III are the same.  Not all Omega III have EPA and DHA in the combinations science shows are most effective and have tocotrienols to increase their impact.  They need to have sardines and anchovies from the most remote parts of the ocean, they need to remove any trace of toxins multiple times.  I like them to follow sustainable practices.  (And no I’m not satisfied that krill oil can do the same.) They won’t be cheap.

If they are, you are consuming toxic waste and wasting your money.

Probiotics

 High-quality probiotics will improve the quality and count of your healthy disease-fighting bacteria.  Some strains will even induce IL-10-producing regulatory T cells which is a scientific way of saying they reduce inflammation, and can help immune function as well as inflammatory disorders of the gut like painful Crohn’s and Ulcerative Colitis.

Antioxidants

As of 2015, there are 1149 scientific studies on antioxidants in pubmed.com.  They work.  They scavenge free radicals that cause inflammation and repair cells.  I like people to have a custom cocktail with a combination of oxygen and nitrogen free radical scavengers:

Grape Seed Extract is typically extracted from the seeds of red grapes which have a high content of compounds known as oligomeric proanthocyanadins (OPCs).  Grape seed extract is extremely rich in polyphenols, compounds with high antioxidant activity.  Many of the clinical studies examining the damage of fluoroquinolones identify oxidative stress as the underlying mechanism of their toxicity.

Red Wine Extract (Resveratrol) is a powerful antioxidant.  This extract is found in grape vines, roots, seeds and stalks, with the highest concentration in the skins.  The antioxidant properties of red wine extract contribute to maintaining healthy circulation by strengthening capillaries, arteries and veins, and promoting overall cardiovascular health.  It is also known to activate the SIRT1 gene, better known as the longevity gene.  The only other known way SIRT1 is activated is by a lifestyle of caloric restriction.

In the late 1990’s, scientists took note of a phenomenon among the French.  There were very low rates of cardiovascular problems in the provinces where residents consistently ate high fat foods and drank red wine.

Scientists concluded that the protective properties of red wine have helped the French maintain cardiovascular health for years and subsequent scientific studies have further shown that the OPCs found in red wine are particularly beneficial for protecting the heart and blood vessels.  There are also clinical studies showing resveratrol is protective of corneal endothelia.  Fluoroquinolones damage corneal endothelia and inhibit regrowth and repair.

Pine Bark Extract (Pycnogenol®) is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne.  This unspoiled and natural forest environment is the unique source of pine bark.  Pycnogenol is one of the most researched ingredients in the natural

Product marketplace.  Published findings have demonstrated Pycnogenol’s wide array of beneficial effects on the

Body.  Pine bark extract is an all-natural combination of procyanidins, bioflavonoids and organic acids.

The extract has three basic properties – it is a powerful antioxidant, selectively binds to collagen and elastin, and promotes the normal production of endothelial nitric oxide, which promotes the normal dilation of blood vessels.

As one of the most potent natural scavenger of free radicals, Pycnogenol combats many aggressive free radicals before they cause oxidative stress to vital organs.  Its super=antioxidant capabilities help support healthy blood platelet activity, support healthy blood glucose levels, reduce mild menstrual cramping and abdominal pain, maintain joint flexibility, promote cardiovascular health, promote healthy sperm quality, maintain healthy cholesterol levels and support a healthy complexion. www.pycnogenol.com

Bilberry extract is derived from the leaves and berry-like fruit of a common European shrub closely related to the blueberry. Extracts of the ripe berry are known to contain flavonoid pigments known as anthocyanins, which are powerful antioxidants. Scientific studies confirm that bilberry extract supports healthy vision and venous circulation. Bilberry extract helps maintain healthy circulation by strengthening capillaries, arteries and veins.

Bioflavonoids are antioxidants found in certain plants that act as light filters, which protect delicate DNA chains and other important macromolecules

by absorbing ultraviolet radiation. They have been found to promote cardiovascular health, help maintain healthy circulation by strengthening capillaries, arteries and veins , and demonstrate anti-inflammatory activity.

Cranberry is a small evergreen shrub containing dark pink flowers that grows in damp bogs and mountain forests. It blooms from late spring until the end of the summer. The shrub’s small red fruits are produced in the fall. The therapeutic properties of the plant come from the fruit. Cranberries contain proanthocyanidin, which are helpful in promoting a healthy urinary tract and supporting a normal pH of urine. Preliminary evidence suggests that cranberries increase the antioxidant levels of plasma and may help maintain healthy cholesterol levels by providing antioxidant protection of LDL particles.   Cranberries have a high ORAC value, next to blueberries.

Blueberries rank highest among many fruits and vegetables for ORAC activity and contain 25-30 different types of anthocyanins. Anthocyanins give blueberries (and other fruits) their rich blue and red coloring, and are a powerful flavonoid antioxidant. The mechanism of action surrounding anthocyanins has been studied at the molecular level, demonstrating effects such as promoting cellular health. Blueberries provide large amounts of chlorogenic acid, which is thought to be important in promoting cellular health. Blueberries support the body’s COX-2 inhibitors and provide a powerful antioxidant defense, supporting a strong, comprehensive antioxidant network within the body.

Grapes contain a variety of phenolic compounds, including anthocyanidins, cinnamates and flavan-3-ols, which have all been shown to be effective in promoting cardiovascular health. Anthocyanidins are powerful flavonoid antioxidants that contribute to maintaining cellular health. Preliminary evidence suggests that anthocyanidins contribute to supporting healthy capillaries and providing antioxidant protection of LDL particles, which help to maintain healthy cholesterol levels and contribute to overall cardiovascular health.

Raspberries contain significant amounts of polyphenol antioxidants, chemicals linked to promoting endothelial and cardiovascular health. Raspberries are high in fiber, are an excellent source of vitamin C and manganese, a good source of vitamin K and magnesium, and contain some calcium and iron.

Raspberries are powerful antioxidants, particularly due to their dense contents of ellagic acid (from ellagotannins), quercetin, gallic acid, anthocyanins, cyanidins, pelargonidins, catechins, kaempferol and salicylic acid. They have a high ORAC value next to cranberries and blueberries.

Elderberries contain the flavonoids rutin, isoquertin and hyperoside, as well as anthocyan glycosides, an essential oil. Elderberries have historically been used to make elderberry wine, elder brandy, and sambuca, a popular cordial. Elderberries have a high ORAC value, and contribute to promoting a comprehensive antioxidant network and stimulating the immune system.

Black Currants are powerful antioxidants, particularly due to their anthocyanins content. They are rich sources of vitamin C, and contain high concentrations of B-vitamins, vitamin A, potassium, magnesium, iron, and calcium. Black currants have a high ORAC value. They contribute to promoting a comprehensive antioxidant network, stimulating the immune system and promoting cardiovascular health.

Pomegranate Extract
One pomegranate delivers 40 percent of an adult’s daily vitamin C requirement, and is a rich source of folic acid and antioxidants. Pomegranates are high in polyphenols. The most abundant polyphenols in pomegranate are hydrolysable tannins, particularly punicalagins, which research has shown to be the antioxidant responsible for the free-radical scavenging ability of pomegranate juice. Many food and dietary supplement makers have found the advantages of using pomegranate extracts (which have no sugar, calories or additives), instead of the juice, as healthy ingredients in their products. Many pomegranate extracts are essentially ellagic acid, which is largely a by-product of the juice extraction process. Ellagic acid has been shown in published studies to absorb into the body when consumed as ellagitannins, such as punicalagins.

Plum Powder contains several powerful antioxidants, with a high ORAC content. They are rich sources of many essential vitamins and minerals.  They are also rich in dietary fiber, sorbitol and isatin. They have been commonly used to promote digestive health, but also contribute to a comprehensive antioxidant network, promote cognitive health and cardiovascular health.

Chokeberries are powerful antioxidants due to their high anthocyanins content. They are rich in vitamins and minerals, and contribute to general health and well-being. They contribute to a comprehensive antioxidant network, scavenging free radicals and promoting antioxidant protection of LDL particles.

Bioperine® is a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper). It contains 95 percent of piperine. The metabolic process that generates energy at the cellular level in the human body is called thermogenesis. Though thermogenesis has been identified as a key factor in maintaining weight loss, it has also been identified as playing an integral role in utilizing the daily food and nutrients that the human body consumes.

It sets in motion the mechanisms that lead to digestion and subsequent gastrointestinal absorption. Piperine, in the patented form of Bioperine®, promotes the body’s natural thermogenic activity. Bioperine enhances the bioavailability of certain nutrients, especially antioxidants.

Vitamin C is found in peppers (sweet, green, red, hot red and green chili), citrus fruits, brussels sprouts, cauliflower, cabbage, kale, collards, mustard greens, broccoli, spinach, guava, kiwi fruit, currants and strawberries. Nuts and grains contain small amounts of vitamin C. It is important to note that cooking destroys vitamin C activity. Vitamin C is integral in supporting a healthy immune system, promoting cardiovascular health, maintaining healthy cholesterol levels and providing an antioxidant defense. The body does not manufacture vitamin C on its own, nor does it store it. Therefore, vitamin C must be acquired through diet and supplementation.

Vitamin E (Natural tocopherol: d-gamma 70%, d-delta 21%, d-alpha 7%, d-beta 2%): is a collective term for a group of compounds from the tocopherol and tocotrienol chemical groups. The most valuable sources of dietary vitamin E include vegetable oils, margarine, nuts, seeds, avocados and wheat germ. Safflower oil contains large amounts of vitamin E (about two thirds of the RDA in ¼ cup), and there are trace amounts in corn oil and soybean oil. Vitamin E is available in a natural or synthetic form. In most cases, the natural and synthetic forms are identical except the natural form of vitamin E is better absorbed and retained in the body. For those individuals watching their dietary fat consumption, which is relatively common in the world of dieting, vitamin E intake is likely to be low, due to a reduced intake of foods with high fat content. The main health benefit of supplemental vitamin E comes from its immune-boosting antioxidant activity. It is also known to provide protection for the cardiovascular system.

Vitamin E is one of the most powerful fat-soluble antioxidants in the body. In turn, vitamin E protects cell membranes from free radicals.  (Most oils are GMO these days and are Omega 6 which is much too abundant in the American diet.)  I prefer a high quality supplement that doesn’t use GMOs.

The combination of vitamins C and E helps form the antioxidant network, allowing the vitamins to engage (synergistically) in each others’ regeneration from the spent state back to the active antioxidant state so that they can continue neutralizing free radicals.

Tocotrienols (mixed isomers)
Palm tocotrienols, along with tocopherols, are members of the vitamin E family and are extracted from the fruit of the palm tree. Tocotrienols are one of the two related families of compounds that are collectively regarded as vitamin E. As mentioned above, vitamin E is one of the most powerful fat-soluble antioxidants in the body, and the antioxidant properties of tocotrienols appear to be superior to those of tocopherols. Dietary sources of tocotrienols include almonds, rice bran oil, pistachios, palm oil and barley. Like vitamin E, palm tocotrienols also help maintain a healthy level of HMG-CoA reductase, a key enzyme in our bodies used by the liver to produce cholesterol. New data on the biological activity of tocotrienols in cardiovascular health maintenance along with its antioxidant properties have raised tocotrienols to a new level of prominence in the scientific community.

Lutein and Zeaxanthin are carotenoids found together in many fresh fruits and vegetables. Within the eye, they are found as pigments in the macula and retina. Lutein and Zeaxanthin act as antioxidants to protect the eye from free radical damage. They help to build macular pigment density, a critical factor in the health of the macula and retina in relation to the clarity of the lens. They also act as filters of blue-light to protect the photoreceptor cells of the retina from light damage. Blue-light wave lengths can generate free radical damage.

Eyebright® is an annual plant with deeply-cut leaves and small, white or purple flowers variegated with yellow, native to Great Britain. There are over 20 species of eyebright that extend over Europe, Northern and Western Asia, and North America. The medicinal portion of eyebright comes from fluid extracted just above the root only when the plant is in bloom.

Eyebright is used for the inflammation of the eyelids, sties and eye fatigue. Eyebright has been used by herbalist since the 16th century for problems of the eyes.

Copper may have some antioxidant properties and acts as a component of enzymes in iron metabolism. It is an essential trace mineral. Copper is needed in normal infant development, iron transport, bone strength, cholesterol metabolism, myocardial contractility, glucose metabolism, brain development and immune function.

Zinc is a component of multiple enzymes and proteins. It is also involved in the regulation of gene expression. Zinc is an essential trace mineral that has functions in approximately 300 different enzyme reactions. Thus, zinc plays a part in almost all biochemical pathways and physiological processes. More than 90 percent of the body’s zinc is stored in the bones and muscles, but zinc is also found in virtually all body tissues. It has been claimed that zinc plays a role in wound healing, immune system support, promoting a healthy prostate gland and supports healthy sperm quality. Because zinc is involved in such a great number of enzymatic processes, it has been found to positively affect a large range of functions, including digestion, energy production, growth, cellular repair, collagen synthesis, bone strength, cognitive function and carbohydrate metabolism.

 Quercetin® is a bioflavonoid that is an excellent antioxidant working synergistically with vitamin C to strengthen the walls of the intricate blood vessels in the eye. It also helps to maintain lens transparency. Quercetin has been shown to inhibit the enzyme, aldose reductase. Aldose reductase has been known to contribute to poor eye health.

L-Taurine is a building block for all the other amino acids. It aids in the transport of potassium, sodium, calcium and magnesium in and out of cells, thus helping to generate nerve impulses. It is a non-protein amino acid and is found in high amounts in the brain, retina, myocardium, skeletal and smooth muscle, platelets and neutrophils. It is plentiful in the fluids of muscle, lungs and nerve tissue. It is classified as an essential amino acid and aids micelle formation and fat absorption. Further, it promotes alertness, mental energy and focus.

Taurine also has antioxidant and membrane-stabilizing activities. It may also help maintain a healthy cardiovascular system while also delivering detoxifying activities. It helps protect the eyes from the harmful effects of UV light and stabilizes the membranes in the cones cells of the eye.

It also supports healthy cholesterol and blood pressure levels. It may also help maintain a healthy cardiovascular system while also delivering detoxifying activities.*

Lycopene is one of the carotenes and a member of the carotenoid family. Lycopene offers a wide range of benefits in helping maintain healthy cardiovascular health, prostate health and powerful antioxidant. More recent research suggests that lycopene, like beta-carotene, may play an important role in keeping vision healthy by preventing cataracts and Age-Related Macular Degeneration (AMD).

Activated B-Complex® With Quatrefolic – People with MTHFR polymorphisms need active ingredients especially folate. Some of the bodily functions that need support of B-complex are nervous system, digestive system, cardiovascular system, skin health, mitochondrial health and cognitive health.  They are easily depleted by our environment, especially prescription medication.

I recommend purchasing from Shop.com, the only legitimate distributor of science based, isotonic nutrition.  There are many dubious knock offs, possibly adulterated and expired on other sites so caution advised.

 

 


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