Cholesterol Deficiency?

Cholesterol Pathway

 

Statins are a class of medications that poison an enzyme, HMG-CoA Reductase. You can’t expect to poison a critical enzyme long term and expect to have a good result. By poisoning HMG-CoA Reductase, all of the substances downstream to HMG-CoA will also be reduced.

Coenzyme Q10 is a biocatalyst that facilitates the activities of enzymes.  It is necessary for maintaining optimal muscle function.  CoQ10 is essential for cellular energy production.  The heart muscle contains one of the largest amounts of CoQ10 in the body.  If statin-induced muscle pain and weakness progresses, it can lead to a potentially fatal condition called rhabdomyolysis.  Doctors will frequently check their patients on statin drugs for an elevated muscle enzyme called creatine kinase.  When CK levels elevate, it suggests a serious problem with the statin drugs.  To avoid these problems, CoQ10, 150-300 mg should be prescribed with every statin prescription.

Brain Fog and Dementia – Adequate cholesterol levels are necessary for proper brain function.  Much of the brain is composed of fats (the majority of which is cholesterol).  Over 50% of dry weight of the cerebral cortex is cholesterol.  The elderly are particularly sensitive to decreases in cholesterol levels.  Cholesterol is the repair item for both the brain and the body; when there is damage to body tissue, cholesterol is produced locally in large amounts to help heal the area.  Those with the lowest cholesterol levels (<150mg/dl) consistently exhibit more brain fog and dementia as compared to those with higher cholesterol levels.

Depression – When there is adrenal fatigue with a resultant suboptimal adrenal hormone production, an elevated cholesterol level is the normal and expected response. When the adrenal hormones become imbalanced, one of the key problems that can develop is depression. By lowering cholesterol, statins can not only cause depression, they also have a tendency to exacerbate a depressive condition.  (TLS ACTS can help with adrenal fatigue.)

Cholesterol is a precursor to Vitamin D production. You are likely to be vitamin D deficient if your cholesterol is lowered. Cholesterol is necessary for proper absorption and digestion of fats and minerals. Cholesterol is the “glue” that holds the entire lipid cell layers together.  Leaky cell membranes could result in chronic illness and cancer. Cholesterol is necessary for the myelin sheath that covers all of our nerve cells.  Cholesterol is necessary for the immune system to fight against infection.

 

Side Effects of Statins

The most common side effect of statins is muscle pain and weakness.  Doctors reporting from individual practices say it is reported by patients about 20% of the time despite published data saying 1 – 5%.  The depletion of CoQ10 would be a logical conclusion for muscle aches and weakness because it is a biocatalyst that facilitates the activities of enzymes; it is necessary for maintaining optimal muscle function and cellular energy production.

If statin induced muscle pain and weakness progresses, it can lead to a potentially fatal condition called rhabdomyolysis.  This is why doctors will frequently check their patients who are on statin drugs for an elevated muscle enzyme called creatine kinase (CK).

The heart is the body’s largest muscle and contains the largest concentration of CoQ10.

Last year (2014) it was discovered statins have a negative effect on stem cells properties and with long term use an increased risk of cataract formation.

Statin therapy and plasma coenzyme Q10 concentration

The Impact of Statins on Biological Characteristics of Stem Cells Provides a Novel 2 Explanation for Their Pleiotropic Beneficial and Adverse Clinical Effects Reza Izadpanah1,2*, Deborah J Schächtele1 *, Andreas B Pfnür1 , Dong Lin1 , Douglas P Slakey2 3 , Philip J Kadowitz3 , Eckhard U A

 Genetics

Lifestyle changes are an alternative to taking prescription medication.  Sometimes statins are necessary but genetics only has a 5% impact.  95% is epigenetics; in other words how your lifestyle choices and your environment interact with your genetics.  How toxic your environment is, including the food you consume which will have a very big impact on your Microbiome (your gut), if you have endocrine disruptors all over your home and workplace, if you take prescription drugs, illegal drugs or smoke.  Exercise can change the expression of some of your genes so it is important.

The polymorphisms discussed below are genes that have been clinically tested in double blind placebo studies where changes in lifestyle were shown to positively impact the expression of the gene.

Fats

ADRB2 Impairs the breaking down of neutral fat (Slower metabolism) and causes unnecessary storing away of energy in the body, advantageous in the time of famine, but is now associated with obesity adjusting to modern day lifestyle.  People with variations of this gene tend to gain weight from carbohydrates.  This is about 50% of the population.

ADRB3 (Adrenoreceptor Beta 3) Susceptibility to and development of T2DM. (Type 2 diabetes)

Impairs the breaking down of neutral fat (Slower metabolism)

Causes unnecessary storing away of energy in the body, advantageous in the time of famine, but is now associated with obesity adjusting to modern day lifestyle.

This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis.

APOA2 (Apolipoprotein A-II) Studies repeated in several ethnic groups showed that the genetic variation can affect BMI but only when saturated fat in the diet is high.

The CC variation with high saturated fat diets, BMI is reported to be significantly higher. CC homozygote individuals have a heightened sensitivity to saturated fat.

FABP2 (Fatty Acid Binding Protein 2) important effect on postprandial lipids in vivo, potentially influencing plasma levels of lipids and atherogenesis.

Uptake and transport of saturated and unsaturated fats. Increased carb sensitivity, lipids and cholesterol.

These proteins participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance.

FTO (alpha-ketoglutarate-dependent dioxygenase FTO) is a protein that is associated with fat mass and obesity in both adults and children. Its function has not been completely determined yet. It is an alpha-ketoglutarate-dependent deoxygenase enzyme that repairs alkylated DNA and RNA by oxidative demethylation. Activity appears to be affected by eating and fasting. The enzyme is particularly active in areas of the brain that are associated with eating behavior.

FTO plays a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.

PPARG Individuals with the Pro/Pro genotype are likely to be more sensitive to negative effects of fats and refined carbohydrates in the diet and to a sedentary lifestyle. It has also been reported that higher proportions of MUFA (mono- unsaturated fats) in the diet compared to saturated fats is linked to a lower BMI This gene helps form and store fat and people with this gene tend to be sensitive to both carbs and fat. Fortunately only about 15% of the population have this variation.

TCF7L2 Increased risk of Type II diabetes. Less weight loss in response to lifestyle intervention unless high fiber intake is present.

Exercise

The genes below put you at higher risk for injury.

GDP is associated with higher tendinopathy risk.  

COLA1A and COL5A1 put you at higher risk for ligament ruptures, shoulder dislocations and an 80% higher risk for osteoporosis. They are also associated with vasodilation, blood pressure control, efficiency of muscular contraction and cell hydration.  Extra stretching and hydration are more important for people who have these genetic variants and their trainers and health professionals (like physical therapists) should be aware of them.

Walking and swimming are low injury risk exercises.  Anything that would add the likelihood of injury should take into consideration these genetics.

Certain genetic variants can determine the best kinds of exercise.  Most people have a combination of power and endurance genes.  Some people have variations that can have more significant impact if they are athletes or trying to lose weight.  Andrew Steele is an Olympian who has received two silver medals, missing the gold by only one second.  To achieve those silver medals he had exercised in a way that was best for his body based on his genetics.  However he did not know that.  To train for the gold his trainers had him change his routine to one that was not aligned with his genetics.  He came down with Epstein Barr, an autoimmune condition some think is related to over-training.  (Possibly it is related more to training in a way that does not support genetics and makes individuals more vulnerable to other variants.) He did not even qualify for his home country Olympics.  This is a dramatic story but an important one for professional athletes to consider.

Diet

A Mediterranean Diet seems to be a sensible diet for most people.  Some may have to have a low-carb diet. Eating organic is important as insecticides, herbicides, chemicals and GMO will impact the expression of your DNA.  Some may not have the enzymes to digest dairy and some may be at risk for Celiac Disease.  Eat a diet that is mostly plants with a few nuts and seeds, healthy fats like avocado and olive oil and meats/seafood.  If you eliminate meats/seafood there could be problems and expert guidance is recommended, including lifestyle genetics.

Dr. Stephanie Seneff believes that the buildup doctors find in arteries is “cholesterol trapped in the wrong place,” or cholesterol trapped in the plaque. The reason it’s trapped in the plaque is because the LDL is damaged from excess sugar in the blood. As a result of our highly processed, starchy, sugary diets, many Americans have excess blood sugar. Once the sugar has damaged the LDL it cannot go back to the liver where the cholesterol would be processed and recycled back into the body. The plaque then builds up in the arteries, where it “waits for the opportunity to become cholesterol sulfate, which all of the body’s systems need,” Seneff says. “The bottleneck is the sulfate. Cholesterol needs sulfate to be mobile. The damage then is a consequence of lack of cholesterol and lack of sulfate.”

This may be why a much larger study in The Journal of the American Medical Association found “no overall significant association between egg consumption and heart disease.” In fact, the study of 118,000 people found that those who ate five or six eggs per week had significantly lower mean serum cholesterol levels than those who ate one egg per week.

Cruciferous vegetables have Sulphur as well and are important for people who have genetic variants that support the liver like GSTM1 and GSTT1.

Sunny Side Up; In Defense of Eggs

Supplementation

Everyone MUST supplement.  Dr. Mark Hyman says it best, “Maybe if we eat only wild, fresh, organic, local, non-genetically modified food grown in virgin, mineral and nutrient-rich soil that has not been transported across vast distances and stored for months before being eaten……AND work and live outside, breathe only fresh unpolluted air, drink only pure clean water, sleep nine hours per night, move the body every day, are free from chronic stressors and exposure to environmental toxins, then perhaps we might not need supplements.”

We still burn coal for energy and the by-product of burning coal is methyl-mercury.  We breathe it, it goes into our soil when it rains and it impacts (especially) root vegetables.  It goes into our water systems and impacts everything in those systems that we consume.

We’ve polluted our air, water and soil with herbicides, pesticides, chemicals and pharmaceuticals.  For example a kind of plastic, BPA will cause an increase in blood pressure.  There is almost 300,000 tons of it in the ocean alone.  We use plastics for everything now.  We should stop using plastics and Teflon coated items for food preparation and storage.

ALTERNATIVES TO STATINS

Antioxidants, Citrus Fiber, Fish Oils, Astaxanthin, Activated B-Complex, CoQ10

Endopat_artery

The above photo shows the inside of a coronary artery which has had the endothelial lining damaged.  There is a medical device called endoPAT that can measure endothelial damage inside the artery.

A bad score can mean a 300% higher risk for an adverse cardiac event.  Two anti-oxidants, OPC-3 and ORAC have demonstrated they can lower a bad score in 90 days using the endoPAT before and after.

(Accelerated antioxidant bioavailability of OPC-3 bioflavonoids administered as isotonic solution.

Cesarone MR1, Grossi MGDi Renzo AErrichi SSchönlau FWilmer JLLange MBlumenfeld J.)

 

Sytrinol

 

 

The photo above contains results from many clinical studies on a patented citrus fiber, Sytrinol.  It can be found in a product called Advanced Lipitrim.  Combined with Fish Oils and Activated-B-Complex it can provide tremendous cardiovascular support.

 

Omega_epa_dha

 

Fish oil has been shown to lower elevated triglyceride levels as well as prevent blood clots and slow plaque growth.  It helps prevent sudden cardiac death and can normalize heart arrhythmias. 1,200 to 3,000mg per day is recommended.

As previously mentioned the oceans are quite polluted.  Senator Whitehouse of Rhode Island gave a speech on the state of the oceans and said when a whale beaches on RI shores, it is considered toxic waste.

There are manufacturers who do a fantastic job of cleaning pollutants out of fish oils.  They only use small fish like anchovies and sardines from remote parts of the ocean and the oil is cleaned and tested several times.  Most fish oils contain many pollutants; these will be the inexpensive ones.

Fish Oils in clinical studies have been shown to have the best bioavailability if they have 3:1 EPA: DHA

Flax Seed oil is no substitute for EPA and DHA as some people may think.  It is not converted to EPA and DHA in amounts required by the human body.

The human eye structure requires EPA and DHA for eye health.  (Resveratrol has been shown to be protective of the corneal endothelia.)

Krill Oil has not been shown to have the same bioavailability of fish oils as of this date 12/25/2015.

Astaxanthin has also been shown to be great for cardiovascular benefits.  It is also a lipophilic supplement like fish oils.

The patented form, astareal, has quite a few clinical studies.

BComplex_active

 

B-Vitamins have so many benefits. They play roles as co-enzymes in the metabolism of protein, fat and carbohydrates, they support a healthy rate of metabolism and healthy skin and muscles. They support immune and nervous system functions and a healthy heart system.  They promote normal cell growth and division, energy and healthy mental outlook, mood and memory.

Some genetic mutations like MTHFR which is prevalent in more than 50% of the population require active ingredients.  Most B-Vitamins don’t have active ingredients.  B-Vitamins are almost always depleted by most prescription medications.

Anyone taking prescription medications and anyone who has eliminated meat would benefit from an active B-Complex.

 

CoQ10

 

 

Finally, sometimes statins are recommended; just a reminder that CoQ10 has to be taken alongside any statin.

Advanced CoQ10 contains the highest quality CoQ10 on the market called OptiPure®; natural vitamin E in its mixed tocopherol form; a unique blend of natural mixed carotenoids, and rice bran oil, providing gamma oryzanol and d-limonene.

CoQ10 is lipophilic which means the body likes to have it delivered in an oil based form, much like Omega IIIs and astaxanthin.

One rule with supplements: you get what you pay for.  Companies that spend millions to get patents that investigate the manufacturers they use, that develop products based on clinical science will cost more.

Bioavailability is critical.  If they don’t get where the body needs them in the amounts that it needs them, money is wasted and the environment is polluted.  Sometimes there will be tradeoffs that have to be made.

Bioavailability and Patents are important determinations. Discuss those with experts.

Information and clinical studies from DRUGS THAT DON’T WORK AND NATURAL THERAPIES THAT DO  by Dr. David Brownstein has been used in this document along with the clinical studies quoted.


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