Methylation – Notes from the Cutting Edge

Methylation ….

Turn genes on and off

Process chemicals and toxins (biotransformation)

Build neurotransmitters (dopamine, serotonin, epinephrine)

Process hormones (estrogen)

Build immune cells (T cells )

DNA and RNA synthesis

Produce energy (CoQ10, ATP, carnitine)

Produce protective coating on nerves

Methylation can be disrupted by

Lack of cofactors driving methylation forward (zinc, magnesium, B6 )

Medications (antacids)

Specific nutrients depleting methyl groups (niacin)

Environmental toxicity, heavy metals, chemicals (acetylaldehyde, arsenic, mercury)

Excessive substrate (Feedback inhibition; too much cysteine, SAMe, glutathione)

Genetic mutations

Prevalent Conditions

 

Diabetes Fibromyalgia
Cancer Chronic Fatigue Syndrome
Pulmonary Embolisms Depression
Cleft Palate Alcoholism
Spina Bifida Addictive Behaviors
Autism Insomnia
Parkinson’s Down’s syndrome
Atherosclerosis Chronic Viral Infection
Neural Tube Defects Thyroid Dysfunction
Immune deficiency Neuropathy
ADD/ADHD Recurrent Miscarriages
Multiple Sclerosis Infertility
Alzheimer’s Anxiety
Dementia Schizophrenia
Chemical Sensitivity Bipolar
Congentital Heart Defects Allergies

 

Contributors

Industrialized farming and ranching (poor nutrition, chemical exposure)

Increased stressors (longer work hours, less sleep, more demands, faster society, technology, digital dementia)

Pervasive chemicals (school, work, food, water, air, soil, products)

Standardized healthcare (symptomatic treatment vs understanding underlying causes)

Lack of education: unaware of common everyday harmful exposures

Lobbyists (protecting big business)

Treatment

Balance Methylation

Multifaceted approach: The Basic Five

lifestyle, diet, environment, mental outlook, nutrition

The approach is demanding, requires patient education, is difficult to achieve,

Hard to maintain and takes time BUT

It is required and sometimes it is still not enough

GENETICS IS THE MISSING FACTOR IN UNDERSTANDING UNDERLYING CAUSES OF DECREASED METHYLATION

Test for MTHFR – C677T and A1298C

Still not improving?

MTR/MTRR – recycles B12 and processes B12 for methionine production

GSTM1 and SOD – major detoxification enzymes

CBS – processes homocysteine and if upregulated depletes methyl groups

Increases taurine

NOS – processes ammonia, forms nitric oxide from argenine

COMT and MAO A – processes and neurotransmitter catabolism and estrogens

GAD – transforms glutamate into GABA

HNMT- processes histamine (secondary enzyme for histamine – primary is DAO)

QDPR – recycles BH4

SUOX – processes sulfites/sulphur, and this mutation is made worse from CBS

upregulation; people with this may get worse when they detox as sulfur by

products are prominent during detox

 

Who Should be Screened?

 

Diabetes Fibromyalgia PreConception
Cancer Chronic Fatigue Syndrome Newborn
Pulmonary Embolisms Mental Health Syndromes Cervical Dysplasia
Cleft Palate Alcoholism Birth Defects
Spina Bifida Addictive Behaviors Drug/supplement Sensitivities
Autism Insomnia Chronic Pain
Parkinson’s Down’s syndrome Elevated histamine
Atherosclerosis Chronic Viral Infection Elevated Cobalamin
Dementia Thyroid Dysfunction Congentital Heart Defects
Immune deficiency Neuropathy Allergies
ADD/ADHD Recurrent Miscarriages Chemical Sensitivity
Multiple Sclerosis Infertility Bipolar
Alzheimer’s Anxiety Schizophrenia

 

Test Everyone

 

Prevalence

 

 

Group One C677T Variant Two C677T Variants One C282Y and One A1298C Variants Two a1298CVariants
Caucasian 25 – 45% 8 – 18% 15 – 20% 4 – 12%
Hispanic US 42% 21% Not known 25%
Black US 14% 1% Not known 2 – 4%
Asian 35% (Japanese 11% (Japanese) Not known 1 – 4%

 

Having two MTHFR  variants is more common than having high homosysteine or any condition linked to high homosysteine.  Atlantic Health. Dnadirect

Learn more at MTHFR.net

 

 

 

 


Happy New Year 2014

 

What have we learned?

“Scientists now see inheritance as more fluid, and the barriers between genes and the environment as more porous.

It’s not all about the genes anymore; it’s about expressing genes, or turning them on and off.  Cells commonly turn DNA off by dotting it with small bumps called methyl groups, or turn DNA on by using acetyl groups to uncoil it from protein spools. ( Read more)

We have changed the climate.

The air is warming and the excess moisture is contributing to more severe weather.

The oceans are becoming more acidic.

We’ve industrialized food.  Grassroots local food movements have sprung up but the incentives are built in for big corporate farming.

Because of the industrialization of food and premature harvesting most food is lacking in minerals and enzymes.  Because of the incentives junk food is cheap.

There is a diabetes epidemic.  The US is the second fattest country in the world.  Mexico is number one.

Coal burning plants used for our electrical grid produce a by-product of methyl mercury.  Methyl mercury is found in high quantities in the ocean (along with other toxins) and is also now being found in root vegetables.

Fracking from gas extraction results in flowback and produced water containing sodium, magnesium, iron, barium, strontium, manganese, methanol, chloride, sulfate, benzene, toluene, ethylbenzene, xylene and natural radioactive substances.

Aside from the by-products of fossil fuels we haven’t seen any dinosaurs lately so sustainable energy has become a priority – at least in other parts of the world.  Germany has more than 300,000 solar homes and it is not a sunny country.

I live in a solar home and it didn’t cost any more to build than one that isn’t.  When storms took out the grid, I still had power. Companies like Solar City, a Google backed company can provide the solar systems without the upfront expense.

There are wind and solar companies now that can provide electricity for the grid.

We have polluted the environment with pesticides, chemicals, drugs, genetically modified organisms including inserting BT toxin into the DNA of food which is showing up in the digestive tract of newborns according to clinical studies in the UK.

We have discovered patients are different.  Their genetics are different.  A one size fits all approach to health does not make sense anymore.

There are MDs curing so called “incurable” diseases by running the human genome and treating the patient based on their genetics.  A doctor in Texas has been doing this for ten years but his treatment does not fit the approval process of the FDA because it is personalized.

There are medical devices now that can help prevent adverse cardiac events ten years in advance.

There are MDs using these devices to prevent issues by helping patients make lifestyle changes to support their genetics.

I do not have the symptoms of inflammatory diseases that I had previously because ten years ago I did a genetic screening, changed my lifestyle and cleaned up my environment.

Despite overwhelming scientific evidence there is still a fundamental disconnect between medical and nutritional mindsets and flawed studies on both sides.

The US pays the highest healthcare costs in the Western World.

The costs of clinical studies are exorbitant.

A gene can be patented but a natural substance cannot.

Experts wouldn’t expect a pill to have the same impact as an IV. They know all versions of drugs aren’t as effective.  Some create worse side effects than others.

However supplements and nutraceuticals are all lumped together.  Most MDs tell their patients to just go anywhere to get them.

The FDA does monitor them but not the way they monitor pharmaceuticals and that is because they usually don’t kill people.

I’ve seen clinical studies on an isotonic solution compared to the same exact powder compressed in a pill form.  The difference in results is dramatic.  And I expect if anyone bothered to study it, there would be differences based on genetics.

This would be true of pharmaceuticals and nutraceuticals.  Some individuals benefit, some could be harmed and some have no impact at all depending on their genetics.

 

Some Interesting facts supported by science based studies:

40% of Americans have the MTHFR Gene SNP

Folic Acid fortification may be causing an increase of MTHFR defects

MTHFR can be related to birth defects and many disease symptoms

47% of Americans take at least 1 prescription drug each month

Close to 100% of prescription drugs deplete some component of B complex

Once a patient is taking 2 prescription drugs, they are likely to be put on an antidepressant

Host resistance and susceptibility to influenza depend importantly on the ratio of vitamin D to vitamin A activity

A 25-hydroxy serum level of 55 is needed to prevent the flu

Researchers have shown that vitamin D status is associated with the immune system, the production of cytokines and chemokine signaling.

Resveratrol can activate the SIRT1 gene.  This has only previously been demonstrated with caloric restriction.

Gene SNPS that have been clinically shown to be involved in weight management and express or not based on lifestyle i.e. the patients can impact these by their lifestyle choices: ACE, ADRB2, PPARGC1A, CRP, IL6, TNFalfa, ENOS.

New clinical studies on weight management will be implemented into genetic screenings this year.

By 2015 the area of nutrigenomics will have exploded dramatically.

Patients are extremely interested in preventing disease as demonstrated by their buying decisions.

The ACA (Affordable Care Act) is now law. Incentives for prevention are built in for health professionals and for patients.

Most health professionals have no business training but many are running a business.

The question is will health professionals become healers and help their patients with this quest or continue down antiquated paths that are demonstrating abominable results and leave their patients to make poor decisions based on marketing alone.

Some health professionals will learn to understand the concept of leverage, the missing ingredient in most Americans lives.  Some will be forced into being hospital employees or employees of other kinds of medical corporations or go broke.

This will be a breakthrough year for some health professionals.  They will change their own health, the health of their patients and they will turn their occupation into an avocation because they will have their time back.


METHYLS and ACETYLS; You gotta lot of splainin to do

Ehyl and Lucy

“Scientists now see inheritance as more fluid, and the barriers between genes and the environment as more porous.

It’s not all about the genes anymore; it’s about expressing genes, or turning them on and off.  Cells commonly turn DNA off by dotting it with small bumps called methyl groups, or turn DNA on by using acetyl groups to uncoil it from protein spools.

And scientists now know that cells pass those precise patterns of methyls and acetyls on to daughter cells whenever they divide – a sort of “cellular memory.”  (Indeed, scientists once thought that the methyls in neurons physically recorded memories in our brains.  That’s not right, but interfering with methyls and acetyls can interfere with forming memories.)

The key point is that these patterns, while mostly stable, are not permanent: certain environmental experiences can add or subtract methyls and acetyls, changing those patterns.  In effect this etches a memory of what the organism was doing or experiencing into its cells.

Unfortunately, bad experiences can be etched into cells as easily as good experiences.  Intense emotional pain can sometimes flood the mammal brain with neurochemicals that tack methyl groups where they shouldn’t be.

Mice that are (however contradictory this sounds) bullied by other mice when they’re pups often have these funny methyl patterns in their brains.  As do baby mice (both foster and biological) raised by neglectful mothers, mothers who refuse to lick and cuddle and nurse.

These neglected mice fall apart in stressful situations as adults, and their meltdowns can’t be the result of poor genes, since biological and foster children end up equally histrionic.  Instead the aberrant methyl patterns were imprinted early on, and as neurons kept dividing and the brain kept growing, these patterns perpetuated themselves.  The events of September 11, 2001, might have scarred the brains of unborn humans in similar ways.  Some pregnant women in Manhattan developed post-traumatic stress disorder, which can epigenetically activate and deactivate at least a dozen genes, including brain genes.

These women, especially the ones affected during the third trimester, ended up having children who felt more anxiety and acute distress than other children when confronted with strange stimuli.

Notice that these DNA changes aren’t genetic, because the A-C-G-T string remains the same throughout.

But epigenetic changes are de facto mutations; genes might as well not function.  And just like mutations, epigenetic changes live on in cells and their descendants.  Indeed, each of us accumulates more and more unique epigenetic changes as we age.  This explains why the personalities and even physiognomies of identical twins, despite identical DNA, grow more distinct each year.  It also means that that detective-story trope of one twin committing a murder and both getting away with it – because DNA tests can’t tell them apart – might not hold up forever.  Their epigenomes could condemn them.

Of course, all of this evidence proves only that body cells can record environmental cues and pass them on to other body cells, a limited form of inheritance.  Normally when sperm and egg unite, embryos erase this epigenetic information – allowing you to become you, unencumbered by what your parents did.  But other evidence suggests that some epigenetic changes, through mistakes or subterfuge, sometimes get smuggled along to new generations of pups, cubs, chicks, or children.”

From THE VIOLINIST’S THUMB by Sam Kean

 

 


VDR

VDR
If you Google VDR you’ll usually get hits for Video Disk Recorder but in the health arena VDR (Vitamin D Receptor)  is a powerful gene that encodes the nuclear hormone receptor for Vitamin D3.

This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II Vitamin D-resistant rickets.

It is a key nuclear receptor that binds nutritionally derived ligands and exerts bioeffects that contribute to bone mineral homeostasis, detoxification of exogenous and endogenous compounds, cancer prevention, and mammalian hair cycling. Liganded VDR modulates gene expression via heterodimerization with the retinoid X receptor and recruitment of coactivators or corepressors. VDR interacts with the corepressor hairless (Hr) to control hair cycling, an action independent of the endocrine VDR ligand, 1,25-dihydroxyVitamin D(3).
There is much spin doctoring on the Internet mostly for marketing purposes. I confess I market as well but do my best to be science based. Unfortunately all the marketing can mask real evidence and lead to skepticism.

There is always the crowd who promotes au naturel and insists you can get all your Vitamin D from sunlight and diet.  They clearly do not live in New England or the Northern hemispheres or parts of the planet that are dark for 6 months.

At one time in the earth’s history before polluted environments and industrialized food it may have been true.

But now there is so much dismaying information about the state of the oceans, environment and climate, food farming along with just plain old personal hygiene information I have a hard time believing we can do it anymore.

A pediatrician I work with did quite a bit of research on Vitamin D and said to get enough from the sunlight it would have to stay on your skin for about 24 hours to be converted.
I doubt there are many of us who don’t bathe for that long a period.  There are other skin specialists who say after a few minutes of exposure it is detrimental to your Vitamin D levels.  And then there is the possibility that prolonged exposure to UVR is linked to skin cancer.

Senator Whitehouse of RI did a speech on the state of the ocean and said when a whale beaches up on RI shores; it is considered toxic waste so unless you want a healthy dose of toxic waste in your diet, seafood is a bit risky these days.  I’ve had food poisoning twice from tuna and sadly have now given it up.

Impaired intestinal absorption and reduced metabolism to active forms of Vitamin D are contributing to deficiencies.

We know that genetics are not cast in stone anymore and some genes can be expressed or not based on lifestyle and environment.  Some studies have shown that low levels of Vitamin D in people with autoimmune diseases are not from deficiency but from chronic infections of bacteria that down regulate the Vitamin D metabolism.

These people have been treated with antibiotics which can be problematic as bacteria are very good at mutating and becoming resistant.  And who knows maybe years of over treatment with medications contributed to this problem in the first place?  Some of the sickest people I know who have auto immune diseases have been on the most meds during their lifetime. I personally know two people with Stevens Johnson’s Syndrome who have probably been on twenty times the pharmaceuticals and over the counter meds in their life that I have and they never really had serious conditions that required them.

More than 50% of postmenopausal women taking medication for osteoporosis have suboptimal levels of Vitamin D.

Environmental toxins like herbicides can contribute to the down regulation of vitamin D.

This year a team of academic researchers pinpointed how Vitamin D3 and omega-3 fatty acids may enhance the immune system’s ability to clear the brain of amyloid plaques, one of the hallmarks of Alzheimer’s disease.

In November Johns Hopkins did a study. Patients with low Vitamin D levels were significantly more likely to develop a condition called recurrent inflammatory spinal cord disease. The researchers considered this finding to strengthen the evidence base of an existent link between low Vitamin D levels and immunologic dysregulation.
Vitamin D3 supports the synthesis of calcium-binding proteins.

Without adequate amounts only 1–15% of dietary calcium is absorbed which is critical in the normal formation of bone and normal bone growth and bone remodeling by osteoblasts and osteoclasts. It promotes regulation of T-cell function and through its interaction with VDR it supports the healthy expression of the gene to maintain healthy blood pressure.

K3 in combination with D3 ensures transport to the bones and blood vessels. Only 10% of dietary Vitamin K is in K2 form so it is not easy to get from food.  And increased Vitamin D3 uses up K2 in the body so it makes sense to have them together. In addition novel dietary ligands for VDR like curcumin, gamma-tocotrienol, and essential fatty acid derivatives likely play a role in the bioactions of VDR.

It does matter when it comes to how to get this additional supplementation into the body.  Some products have rancid oil in them leading to UTIs (Urinary Tract Infections).

IV is the optimal form of delivery to the body so anything that is designed to mimic that and has the science to prove it should be of interest to health professionals.
Recently I’ve met so many more professionals who are taking the time to learn the science to advise their patients but they drop the ball when it comes to where the patient should get the solution.

The FDA does not monitor the industry so professionals really need to be educated when they advise patients.

Just go to Amazon or CVS is what patients tell me they were advised to do.

If I go online or to a store I experience the same dilemma I did in the supermarket when my children were little and I was in the cereal aisle. It was a little easier with cereals.  I told my son anything with less than 5 sugars which served to educate him on all the different kinds of sugars and served me as I knew the only one would be Cheerios.

And I could use them for toilet training.  Shoot for the center I told my son.

Unfortunately, I don’t think we want to play games with nutrition. I played the shotgun approach for 40 years wishing my doctors could advise me and just tell me the good one. I probably took many things I didn’t need and wasted my money because it wasn’t getting into my system.  When  patients are surveyed many express they feel this way.

Three elderly patients told me they were instructed by their doctors not to take Vitamin D3 because it contained Vitamin K.  I’m guessing their doctors were thinking of Vitamin K1 which is concentrated primarily in the liver and at high doses may interfere with anticoagulant medications.

But the fact that some doctors were unaware of the difference in the two K Vitamins compounded by the fact that lack of patent incentives means a dearth of  scientific evidence in the US is a case for more preventive education in medical school and in continuing medical education where the education is now heavily weighted towards the pharmaceutical industry that is rewarded by patents.

And as we move into the Fall/Winter season the evidence of adequate intake of not just Vitamin D3 with K2 but all essential nutrients in preventing viruses and upper respiratory infections is important, especially for children and the elderly. If we can’t make it we need to take it.

The future is very exciting.  The research is moving at a fast pace due to the resurgence of rickets and the prevalence of autoimmune disease.

Finally this season is different.  The Affordable Care Act is being implemented and rewards patients and doctors for prevention and not just in the form of expensive medical tests.  It’s about time so we all don’t have to keep playing the shotgun approach. Thankfully President Clinton who has a knack for simplifying what others have tried to obfuscate is making the rounds speaking on the benefits of the ACA.


TNFα, The Good, The Bad and The Ugly

TNFαTumor necrosis factor alpha

The last newsletter I wrote about a recent event that happened to me.  I developed an abscess next to my appendix and my immune system walled it off, saving me from surgery and possibly saving my life.

Over the years I have noticed that I have tendencies towards infection.  When I was three years old I got the mumps and they abscessed.  When I would have work done on my teeth, I would get an abscess.  I got an infection after the birth of my daughter and became septic and now this recent abscess.

I have the Gene SNP TNFα (tumor necrosis factor-alpha.)

I’ve been fortunate to know a very famous genetic scientist who helps develop genetic screenings, Dr. Keith Grimaldi.   I’m not a doctor myself nor am I a scientist but I love to learn about science especially genetics.  Dr. Grimaldi has explained to me that many Gene SNPs have a benefit as well as a detriment.

Some genes, including TNFα, can be impacted by our lifestyle.

He has also explained that in instances like TNFα if the recommended lifestyle changes are not made we will not get the benefits of the gene expression nor will we offset the detriments.

Of course this is just a guess but in the case of the abscess recently it may have been a benefit to have this variant.

Tumor necrosis is involved in the immune response to bacterial, viral, and parasitic invasions.   It is also an acute phase protein that initiates a cascade of cytokines and increases vascular permeability, thereby recruiting macrophages and neutrophils to a site of infection.

TNFα is a proinflammatory cytokine produced in many inflammatory and autoimmune diseases such as rheumatoid arthritis, Crohn’s disease, multiple sclerosis, or chronic hepatitis C.

It is produced by different cell types including macrophages, monocytes, T-cells, smooth muscle cells, adipocytes, and fibroblasts. This cytokine is also implicated in the diseases of the central nervous system like Alzheimer’s and Parkinson’s diseases, where it can be produced by several cell populations, including microglia, astrocytes, endothelial cells, Th1 lymphocytes and neurons.

TNFα can have pathological consequences such as promoting the growth of some tumor cell types. It also plays an important role in the chronic inflammation that occurs in various pathologies and has been identified as the major mediator in various autoimmune diseases.  TNFα thus represents a good marker of inflammatory events.

 

Endothelial dysfunction is an early indicator of cardiovascular diseases, including that seen in type 2 diabetes. Accumulating evidence suggests that mediators of inflammation may be pathogenic by inducing vascular dysfunction. Among the various inflammatory factors, TNFα  plays a pivotal role in the regulation of vascular function in various pathological status .

It can either exist in a membrane-bound form or be secreted as a soluble cytokine that is able to diffuse from the sites of its initial production . It can bind to, and thus functions through its receptors, TNF receptor type 1 (TNFR1) and TNF receptor type 2 (TNFR2).

Dietary supplements and exercise are emerging as effective adjunctive therapies targeting endothelial dysfunction and vascular wall inflammation. This review summarized the vasoprotective effects of dietary supplements and exercises by inhibiting TNFα production and TNFα-induced signaling (Figures 1 and 2).

 
Figure 1: Dietary supplements (fish oil, dietary fiber, and various flavonoid and nonflavonoid natural products) exert vasoprotective benefits by inhibiting TNFα production and its downstream signaling pathways. There are dichotomies in the effects of exercise training on TNFα production. Whereas acute exercise has been reported to increase the production of proinflammatory cytokines, chronic exercise reduces TNFα levels.  Thanks to Hindawi.com

 

 
Figure 2: Multiple mechanisms are involved in the vasoprotective effects of dietary supplements and exercise by inhibiting TNFα signaling.  Thanks to www.Hindawi.com

 

More information:

TNFA curcumin

Curcumin Protects Neuron against Cerebral Ischemia

 

Curcumin induced apoptosis or necrosis of macrophages

 

Curcumin Protects against UVB-Induced Skin Cancers

 

TNFA eye health

 

TNFA Omegas

Vasoprotection of Omegas

 

TNFA Resveratrol

Vasoprotection of resveratrol

Neuroprotective effects of resveratrol

Protective effects of resveratrol on cytotoxicity

 

If you’d like to purchase high quality nutraceuticals from an excellent certified health provider.

 

 


Increased risk of cancer, especially throat, bladder and lung

Genetics is like a loaded gun and environment is the trigger.

I will periodically be posting information on Genetic SNPs.  A SNP is a Single Nucleotide Polymorphism.  Genes make enzymes that drive all the activities in your body.

In plain English it means we are all different.  DNA is not written in stone the way we used to think it was.  You can change the expression of many of your genes by the way you live.  You lifestyle is part of the trigger of your genes.

This posting is about GSM1, Gluthione S-Transferase MU 1.

GSTM1

This particular gene is responsible for producing the enzymes the body needs for metabolism and for detox.
Many of the one-third of our population that suffers from chronic disease is missing this essential gene.

If this gene is missing, the body cannot naturally get rid of heavy metals like mercury (linked to chronic fatigue), antibiotics, pesticides and other environmental toxins.

These people are missing GSTM1 function — one of the most important genes needed in the process of creating and recycling glutathione in the body.
Because of this, the risk of cancer, especially throat, bladder and lung tumors, is increased in those who do not carry the gene. Smokers are more at risk of coronary heart disease.

Some MDs have said nearly all of their sick patients are missing this function. That includes me.

I struggled with allergies, sinus headaches and other inflammatory issues.
Recently I had an abscess from appendix (which has a 56% genetic factor).

Luckily I’ve built up my immune system over the last decade and every MD in the hospital I saw (at least 6) remarked it was impressive that my body walled off the abscess at my “boomer age.”

Sadly, not a single one of the MDs, no matter age were familiar with GSTM1 which has a huge impact on 30% of their patients, especially the hospitalized ones!
I had to educate doctors on my treatment related to pharmaceuticals from my hospital bed.  To their credit some even went and did their own research.
“The Importance of Glutathione in Protecting Against Chronic Illness

 

Glutathione is critical for one simple reason: It recycles antioxidants. You see, dealing with free radicals is like handing off a hot potato. They get passed around from vitamin C to vitamin E to lipoic acid and then finally to glutathione which cools off the free radicals and recycles other antioxidants. After this happens, the body can “reduce” or regenerate another protective glutathione molecule and we are back in business.

However, problems occur when we are overwhelmed with too much oxidative stress or too many toxins. Then the glutathione becomes depleted and we can no longer protect ourselves against free radicals, infections, or cancer and we can’t get rid of toxins. This leads to further sickness and soon we are in the downward spiral of chronic illness.
But that’s not all. Glutathione is also critical in helping your immune system do its job of fighting infections and preventing cancer. That’s why studies show that it can help in the treatment of AIDS.

Glutathione is also the most critical and integral part of your detoxification system. All the toxins stick onto glutathione, which then carries them into the bile and the stool — and out of your body.

And lastly, it also helps us reach peak mental and physical function. Research has shown that raised glutathione levels decrease muscle damage, reduce recovery time, increase strength and endurance and shift metabolism from fat production to muscle development.

If you are sick or old or are just not in peak shape, you likely have glutathione deficiency.
In fact, the top British medical journal, the Lancet, found the highest glutathione levels in healthy young people, lower levels in healthy elderly, lower still in sick elderly and the lowest of all in the hospitalized elderly.
Keeping yourself healthy, boosting your performance, preventing disease and aging well depends on keeping your glutathione levels high.

It is critical for immune function and controlling inflammation. It is the master detoxifier and the body’s main antioxidant, protecting our cells and making our energy metabolism run well.”   Mark Hyman, MD
More clinical studies on GSTM1

GSTM1 glutathione S-transferase mu 1, May 5th, 2013

Asthmatic airway neutrophilia and GSTM1, January 1, 2013

Leukemia and GSTM1, February 27, 2013

Recent article on microbes and the immune system


So now you know you might have a heart attack or stroke in the next decade. Uh Oh bye bye baby if you don’t do something. NOW

 

You’ve been tested on the Endo PAT.  You have endothelial dysfunction.

NOW WHAT DO YOU DO?  Most doctors will NOT be able to tell you because they don’t prevent disease.

Fortunately many doctors (like Dr. Marsha Nunley in San Francisco) are functional medical doctors.

Dr. Dan Witkowski in Boston area is an example on the East Coast.

They’ve seen the light because they got sick themselves and saw their own solutions didn’t work for them or they didn’t work for their families or patients.

Doctors mostly treat symptoms and treat a disease once you have it.  They do an excellent job at triage. Very few of them are trained to prevent disease.  They are incredible people who work long hours and their job is being made harder and harder but I do believe our country’s shift to giving incentives for prevention is the right way to go.  We need to prevent disease so people have a quality of life not just treat symptoms and keep them alive to be miserable.

The first thing you should do is examine your diet and environment.

You need to filter your water!  Genetics is like a loaded gun and environment is the trigger.  Do some quick research on water in the USA or anywhere.  We’ve made a mess.  A whole house filter is best but if not drinking water and shower water should be filtered.

You need to switch to more of a plant based diet.

So that means PLANTS.  Lots of fruits and lots more vegetables.  Eliminate most anything that is man-made.  Yup that means no boxed, canned, bottled, packaged stuff.  Especially do not consume anything that is GMO (genetically modified).  Unfortunately, most of the time GMO is not being labeled in this country (USA) so you should try to eat organic for that reason.

If you have endothelial dysfunction you should stay away from meats for the most part, at least for now until you repair the damage.  You may have to eat small amounts of meat depending on your genetics.  For example it is very hard to get folate into your body if you have multiple variations of the MTHFR gene. Thanks Dr. Jackson!  I’ve written about genetics in several blogs previously.  You can read more here.

There are excellent science based products now that can give incredible results if people will stick with it.

For example here is a fellow that tested on the EndoPAT and the results were not good.  He took a regimen of nutraceuticals and then retested on the EndoPAT.

 

I’ll let him tell you:

Hi Kathy,

­

When you introduced me to nutraMetrix, I was especially interested in the OPC-3 and ORAC products.

 

As you know we sell the Endopat, a device for diagnosing a condition called endothelia dysfunction.  This condition, left untreated, leads to cardiovascular disease.  It has been shown that people with this condition have 300% more adverse cardiac events than those normal endothelia function.  As a diabetic, coronary artery disease is always a concern.  I tested positive for this condition last year.  I have managed to get my score from 1.19 to 1.53 by better managing my diabetes but I was still in the red zone.

 

A little over 90 days ago I started taking the ORAC   and OPC-3 formulas.   I just repeated my Endopat and my score came up to 1.99!  This is in the healthy range.  I no longer have endothelia dysfunction.  Thank you for the introduction.  You may have saved my life!

Regards,

Buck Fechik

President Reliance Medical

Another testimonial from endoPAT testing:

Recently an MD I work with attended a CME training in New Orleans.  The Medical Director of Itamar, maker of endoPAT was there.  She was testing the doctors in attendance.  Many of them had borderline endothelial dysfunction scores.  The doctor I work with (owner of WiWat!  in Melrose, MA) tested 3.10.  A healthy score is 1.67.  Below that is unhealthy, above is healthy.

He has been on the isotonic antioxidants for several years as well as living a healthy lifestyle.

 Testimonial based on blood work

Dear Kathy,

Thank you very much from the bottom of my heart.

A year ago, I had blood tests that showed a cholesterol level of 224. When my husband lost his job, I applied for medical insurance and was turned down, partially due to mycholesterol level. So my health insurance became taking your  nutritional therapeutic recommendations, primarily Isotonix.

Now, my husband has a new job and we have insurance, so I got my blood work done again. The results show my cholesterol has dropped 15% into the normal range. All the other indicators are also normal, with the only exception being related to my allergies.

Because I took the GeneSNP screening, we know that I have a MTHFR DNA issue, and can expect raised histamine levels.

Unlike supplements that I have been on in the past, Isotonix work faster. I can sometimes instantly feel better. And on days when I don’t take it, I notice the difference too. I do not have to wait to eat to feel better. I don’t have to depend on good digestion to break down the supplements. I can enjoy eating meals without swallowing a lot of pills throughout.

Having most of my Isotonix now in one Custom Cocktail saves time too. Thanks for suggesting that solution.

Best,

Betsy

Another testimonial based on blood work

“As you know I have insulin dependent diabetes.  I guess I am considered a “brittle diabetic”.  I have not been able to get my A1C under 9 points in years and years.  Most recently, in October, my A1C was 15.  My cholesterol was very high and I have taken 80 mg of Lipitor for10 years or more.  I have a partially torn ACL in my left knee and have been on pain pills for 3 years to get through my daily activities.  It has not been easy.

 

But in November, after I met you, I started taking OPC-3, Activated B complex and the Multivitamin.  I had blood work done at the end of January.  My A1C came down 6 points!!! I cannot imagine how great it will be after the full 6 months of the OPC-3 affects my A1C.  My cholesterol is at 117, my triglycerides came down as did my LDL and HCL levels.  I have not taken a pain pill in the last 2 1/2 months.  OPC-3 has been a miracle.  I don’t remember feeling this good in a long, long while.”

 

Laurie

These products are ONLY available on Shop.com  and nutraMetrix.    If you find them anywhere else they could be knockoffs or expired.  Don’t be fooled.  Make sure it is the real thing.

 


How would you like to know a decade in advance if you will have a heart attack or stroke?

Well now you can.  There is incredible new technology called Endo –PAT.  This device measures endothelial function.  Endothelial cells are incredibly important cells in your body. You can learn more about them here  but I compare them to the earth’s atmosphere.  It is a very thin layer around the planet but if it disappears, we’re all likely dead.  It’s the same with endothelial cells.

 

Several people I know died of cardiac events recently and my Dad died in 1978 from one…at the Super Bowl in New Orleans no less!

 

I wish I could have pointed them in the direction of this device.

 

It is the only device granted FDA clearance to noninvasively detect endothelial dysfunction.  If you get a score of less than 1.67 you have damaged endothelia and you are in trouble.

 

I think this device is amazing; almost as amazing as the two products I recommend to benefit the repairing of the endothelia in 90 days.

 

More and more physicians are recognizing Endo-PAT as a valuable clinical tool for cutting edge prevention and treatment of CVD and assisting health professionals to save lives in the following ways:

 

  • The early detection of CVD

 

  • Risk Stratification

 

  • Titration

 

  • Monitoring of treatment efficacy

 

  • Patient compliance

The following are just some of the key features that make this technology so user friendly and clinically viable:

  • Highly accurate and reproducible

 

  • User/Operator Independent

 

  • 15 minute test

 

  • FDA cleared & CE marked

 

  • Instant Report Generation

 

I have attached the following information for your review:

  • Endo-PAT Publications Booklet

 

  • Endo-PAT Physician’s Playbook

 

  • Endo-PAT Product Overview

I would encourage anyone reading this to learn about this device and talk to health professionals about it.  Sivan Ebril can be contacted at ESivan@itamar-medical.com and Buck Fechik can be contacted at Reliance Medical  bfechik@reliancemedical.com.

 

Here is the blog about two products that can be taken to benefit endothelia once the damage is diagnosed.


Warm, Well and Stress Proof; A Wellness Play in Three ACTS

I have always thought that maybe I just feel so cold every winter because I had one of those overenthusiastic mothers who think babies should be outside all of the time and I was just having memories of the good old days. I was born in Malone, NY where my dad was attending Clarkson College. It was pretty cold there. My grandmother alluded to frost on the “inside” walls of resident housing. She also enjoyed telling how I was put outside in my snowsuit and would freeze to the ground when I wet my diaper so that I would have to be “chipped up” from the ice.

I used to think that’s why I was cold. Now I’ve changed my mind. I had no idea how powerful a couple of walnut-sized glands could be. They start a chain reaction that is like a giant domino effect going on all the

time in each of our bodies! This domino effect can produce all kinds of symptoms.                                                                                                                                                                        

The villain in this story is STRESS. Stress is wired into us as a fight-or-flight reaction that is an ancient biological life saver. Most of us don’t have sabertooth tigers chasing us, but our brain can’t distinguish acute stress caused by a life-threatening tiger attack from the day-in, day-out stress caused by rude drivers, snowstorms, angry teenagers or even social media overload (like this newsletter). The brain responds to stress as if life is in danger, and a chain reaction is set in motion.

Of course we could learn stress management, we could exercise, we could eat right.

But some of us already do all of that and we still have a problem. If you do, this note is

for you!

It isn’t your fault. You can do everything right, but it’s not enough, especially if you happen to be a particularly sensitive human and have genetic polymorphisms.

Here is what is going on: you are experiencing Chronic Stress, scientifically known as HPATGG Axis.


(HPATGG stands for Hypothalamus, Pituitary, Adrenal, Thyroid, Gonadal, Gut.)  Your brain identifies a threat and your body goes into a fight-or-flight reaction that causes a cascade of hormonal action as one after another, these glands are triggered and then trigger the next one to react in turn.  If it happens many times a day ( face it, it does), this leads to glandular fatigue that we can sum up as energy fluctuations, disturbed sleep, food cravings, body weight issues (fat increase), mood alterations, depression, impaired physical performance,

mental confusion, and yes, maybe even hair loss and freezing butt.

 

The good news?  There is a solution and Nature has had them all along.  They are called Adaptagens.

You can see their photos on the right.

You might think of them as the grown-up equivalent of a warm bath, relaxing massage, warm blanket and a cuddle all rolled into one.  HOLY BASIL!  No really, that’s the name of one of them.  Another, Rhodiola Rosea was used by the Soviet military and competitive athletes

to maintain healthy thyroid function under stress.  You might prefer the Indian botanical Ashwaganda.  Now that’s just plain fun to say.  Many of us have already heard of Siberian Ginseng.  Down in Brazil they’re using Passion Flower (of course!)  There are others – Bacopa Monnieri, and  L-Theanine to name a few.

The bottom line is, these botanicals can mitigate the issues caused by chronic stress.  They promote healthy levels of cortisol and stabilize mood (without the nasty side effects that go along with use of antidepressants that leave some folks worse off than they started – oh I forgot the drug company says it only does that to teenagers – and of

course they are dispensible.


So seriously, there are safe, healthy ways to beat stress even in this

modern day.  Don’t let the modern-day equivalent of sabertooth tigers       

bring you down.  You can give your body a fighting chance with the flower

power of botanicals!)

Stay warm!

To learn more about Adaptogens click the flower pictures.

Looking for a bioavailable, quick delivery, high quality nutraceutical?

Write me at Kathy@criticalhealth.org