Are You a Certified Health Professional?



Are you interested in leading patients to action, not just treating disease?

Right now there are affordable, clinically proven, science based genetic approaches that offer a blueprint to health based on lifestyle changes.

Isn’t that what 90% of American disease states are?  Pro-Inflammatory conditions based on poor lifestyle choices?

Call me.  It can make all the difference to your practice and even more importantly, to your patients.

Kathy Kaufman






When I was a kid food was different.  We didn’t have much packaged food.  We were 6 in my family so meals had to be affordable.  My Mom mostly made soups and stews or meat and vegetables.  We were rarely allowed sugary foods – only on birthdays. That included soda.  My Mom had a craving for salt so she would order Charles Chips by the container and sometimes their pretzels. (But those were mostly for her and she kept them hidden for special treats.)  Fruit was our snack.  Nobody in our family was overweight.  Thank you Mom!

Recently (the last decade) I’ve had the amazing opportunity to study lifestyle genetics.  I find I have all the carb sensitivity gene mutations (proven with clinical studies) and many of the fat sensitivity gene mutations.  I have blood sugar mutations.  I have a profile that would set me up to be overweight if all of those genes expressed but because my Mom had us on a low glycemic eating program, they did not express.

When I went to college I went “hog wild” and ate packaged crumb cakes, cookies, all kinds of carbs and drank soda.  No surprise I gained 25 pounds.  I managed to lose it all by taking up racquetball and for 30 years I maintained my weight with exercise.

Last year my Mom died. She had just turned 88 and had blocked arteries. Her first symptom was extreme pain. She was told she had shingles. I suggested she have a stress test.  They found the blockages.

She was recommended open heart surgery.  I work with many kinds of health professionals.  Not one of them thought that was a good idea.  If she did not have the surgery she would die.  But we (the health professionals and myself) all felt if she did have the surgery, she would not recover and the end would be beyond miserable.  My siblings encouraged her to have the surgery, I believe out of their own desire to keep her alive but also because the hospital MDs said she could make it.  They likely knew she could not survive this surgery.  They also most likely knew what her end would be like.

So why would they do that?

That is what my best friend calls a “walletectomy.”  I don’t blame MDs.  They have to follow hospital protocols or they can get sued.

So why is it the hospital protocol?

That brings us to the United States medical system.  You can’t avoid politics if you are talking about health.  The U.S is the only western country that doesn’t take care of its citizens’ health.  Right now they want to downgrade the little care they do offer.  Why?  Because the current administration values the support of business more than they value the quality of life of their citizens regardless of the spin they constantly put out.  And BTW, the alternative to truth is falsehood.

But, I digress….

After my Mom’s surgery she told me she was being “blamed” for not trying to do the exercises and recovery routines they recommended.  During this time her organs were all struggling to recover.

I’m pretty sure my Mom continued her low glycemic style of eating most of her life but I learned eventually she was an alcoholic – the secret kind.  It’s always a clue when someone BRINGS alcohol with them to visit you.  Just in case…

The point of my story is I BELIEVE in low glycemic lifestyle. Alcohol is not part of it. Alcohol will make you fat and it will contribute to heart disease.  It also puts you at a higher risk for cancer.

Once in a while is a good rule for most things.  I have a glass of red wine maybe 3 times per year and I can only drink about an inch of it because I have liver detox mutations and a whole glass will give me a hangover. Yuk.  What is once in a while for you?

I’d suggest once/week.

If you can’t do that, I’d suggest you ask yourself why.

I’m a super enthusiastic proponent of the TLS system for weight management and healthy cardiovascular system.  I highly recommend you watch this video and then do the quiz.  Does it cost money?  Yes.  Is it worth it?  YES YES YES!!!!  I will personally help you to be accountable on a daily basis, no fee.  This will be the last program you will every need to get fit. I’ll add one caveat – IF YOU ARE READY to stop yo yo-ing.

It would be my pleasure to speak to you.

If you are a health professional who would like to be the health leader you know you can be, implement epigenetics, weight management, prevention, etc. ….

It would be my pleasure to offer a complementary proposal and the support you deserve., 617.515.7559.

Below is more information on cardiovascular support and weight management for the science minded, clinically trained.  This infographic is also for women. Women can commit domestic violence, assault, be aggressive, etc.

An article by Dr. David Brownstein, (MD),03/18/17 about using cholesterol to diagnose heart disease

In an on-line article in The New York Times today (3.17.17), the headline states, “Cholesterol-Slashing Drug Can Protect High-Risk Heart Patients, Study Finds.”  The article describes the first test of the new cholesterol-lowering medication—Repatha.  Repatha is part of the PCSK9 inhibiter family that works by lowering LDL-cholesterol levels through poisoning an enzyme—PCSK9–thereby allowing LDL receptors to remain in circulation.  LDL receptors can bind LDL-cholesterol, thus more LDL receptors will result in lowered LDL-cholesterol levels.


I have written about PCSK9 inhibitors before.  In my book, The Statin Disaster, I wrote, “I do not think PCSK9 inhibitors will be an effective treatment for heart disease as it will disrupt a normal physiologic process in the body: the binding of LDL to its receptor.” (1) So, let’s look at the first study which was published in the New England Journal of Medicine, March 17, 2017. This was a randomized, double-blind, placebo controlled trial involving 27,564 subjects with heart disease and LDL-cholesterol of 70 mg/dl or higher who were receiving statin therapy.

The primary endpoint was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization.  Keep in mind that hospitalization for angina and coronary revascularization (i.e., coronary artery bypass graft surgery or stent placement) are considered soft endpoints since the decision to hospitalize or place a stent is a subjective decision by the physician.  The ultimate success of any cardiac medication should be based on hard endpoints such as death, heart attacks, or stroke.

After 48 weeks of Repatha therapy or placebo, the authors reported that, compared to placebo, the Repatha group significantly reduced the risk of the primary end point by 15% (9.8% in the treatment group vs. 11.3% in the placebo group.)  However, as I have pointed out to you before, the 15% reduction is actually a relative risk reduction.  The relative risk is a statistical term that has no meaning when considering whether to recommend or not recommend a therapy to a patient.  A more accurate assessment is the absolute risk difference.  In this case, the absolute risk difference between the two groups is 1.5%.  A more accurate description of the results should state: as compared to placebo, taking Repatha for two years’ results in a 1.5% decline in a combination of outcomes including death, stroke, myocardial infarction, hospitalization for angina and coronary revascularization.  Another way to look at the data is that the drug failed 98.5% who took it as they received no benefit.  And, if you take out the soft endpoints, the 1.5% decline disappears.

I called Specialty Pharmacy to find out how much Repatha costs.  I was told Repatha costs $2,351.05 per month for a total of $28,212.60/year). So, a two-year course of the medication costs $56,425.20.  (Note; The NYT article states the drug costs $14,523 per year.)

For the physicians, out there, I have a question for you:  Who the heck would prescribe an expensive drug, associated with serious adverse effects, that fails 98.5% who take it?

For the patients, out there I have a question for you:  Who the heck would spend $28,212.60/year for a drug that is associated serious side effects and fails 98.5% who take it?  In this study 25% of those that received Repatha reported serious adverse effects.     What were the serious adverse effects?  I don’t know—they weren’t listed individually.

Repatha is another example about what is wrong with conventional medicine. President Trump just released his first budget.  I would advise him to start tweeting about the failure of Repatha and why it should not be allowed in the market place.  There are far too many ineffective, expensive drugs right now.  We don’t need another one.  Statins are a great example of ineffective drugs that fail nearly 99% who take them.  Now we can add PCSK9 inhibitors to the pile of poorly-performing drugs.

More information about cholesterol lowering medications can be found in my book, The Statin Disaster.

Repatha for heart disease?  Fugetaboutit!

The Triglyceride/HDL Cholesterol Ratio. What Is Ideal?

Many studies have found that the triglyceride/HDL cholesterol ratio (TG/HDL-C ratio) correlates strongly with the incidence and extent of coronary artery disease. This relationship is true both for men and women.

One study found that a TG/HDL-C ratio above 4 was the most powerful independent predictor of developing coronary artery disease.

With the increasing prevalence of overweight, obesity, and the metabolic syndrome this ratio may become even more important because high TG and low HDL-C is often associated with these disorders.

The TG/HDL-C ratio can easily be calculated from the standard lipid profile. Just divide your TG by your HDL-C.

However, when looking at the ideal ratio, you have to check if your lipid values are provided in mg/dl like in the US or mmol/L like in Australia, Canada, and most European countries.

If lipid values are expressed as mg/dl (like in the US);

TG/HDL-C ratio less than 2 is ideal

TG/HDL-C ratio above 4 is too high

TG/HDL-C ratio above 6 is much too high

If you live outside the US or are using mmol/L, you have to multiply this ratio by 0.4366 to attain the correct reference values. You can also multiply your ratio by 2.3 and use the reference values above.

If lipid values are expressed as mmol/L (like in Australia, Canada, and Europe);

TG/HDL-C ratio less than 0.87 is ideal

TG/HDL-C ratio above 1.74 is too high

TG/HDL-C ratio above 2.62 is much too high

My lifestyle genetics

My good friend Nancy Miller-Ilhi, PhD

NIH clinical study LeptiCore

Parkinson’s Symptoms



Article by Steve Kroening, ND

Jack was a Vietnam veteran who worked as a computer specialist. At the age of 55, he began to experience tremors on the left side of his body. It didn’t take long for the doctor to diagnose Parkinson’s disease. He went through the gamut of medical treatments, but none of them seemed to help. His conditioned only worsened.


Jack’s life was falling apart. According to his report, “He was very self-conscious of the constant tremor in his left arm and left leg, which interfered with sleep and sitting comfortably in a chair, and made him feel conspicuous in public. He was having great difficulty working at his job as a computer specialist for a large computer corporation and found it almost impossible to type on a keyboard or to maintain focus during conference calls. He was also experiencing severe anxiety, depression, panic attacks, and insomnia.”

With little hope, he went to see an integrative doctor. The doctor gave him intravenous (IV) glutathione treatment along with a host of other treatments. The glutathione was the only treatment that gave him any relief from the tremors, but they lasted only about 30 hours. Then the tremors would return. According to the doctor, it was more of a “Band-Aid approach to the disease.”

That’s when the doctor came up with a novel approach to his treatment. The doctor knew that the only part of Jack’s medical history that seems relevant to the disease was his Vietnam experience. That’s where he was exposed to Agent Orange. Much like pesticides, which I’ve discussed in the past as a possible cause of Parkinson’s, Agent Orange is a neurotoxin. So it’s quite possible it was the root cause of Jack’s tremors.

Since neurotoxins damage dopaminergic neurons, the normal treatment for Parkinson’s is L-dopa. L-dopa is one of the only effective ways to reduce the tremors, but it has some side effects. The primary side effect is nausea, so doses can go only so high. At upper levels, the nausea can be severe. As a result, researchers have been looking at ways to reduce the side effects and reverse the Parkinson’s. The treatment that has emerged from this research as the most effective is amino acids. Because of past research, this doctor put Jack on a course of amino acid treatment along with the L-dopa.

For Jack, the amino acid treatment allowed the doctor to increase the dose of L-dopa. For a while, Jack didn’t notice anything different. Then, as if someone turned on a light, the symptoms disappeared. This tends to be the way amino acid treatment works. It doesn’t typically cause a gradual relief of symptoms (though about 5% of patients will see gradual relief). Instead, symptoms just cease almost instantly. The affect is remarkable.

Here’s Jack’s report: “Within four months of initiating treatment, the patient experienced dramatic improvement in the tremor in both the upper and lower extremities. He regained coordination in his left hand and was once again able to use the computer keyboard. He resumed his hobby of guitar playing and was able to perform proficiently. His gait and balance were restored. The depression improved significantly. Anxiety was significantly relieved. The patient had lost his fear of going out in public.” And the results were maintained for at least two years.

That’s amazing!

With these incredible results, it’s important to note that the amino acid treatment isn’t considered a cure for Parkinson’s. It’s only a way to manage the symptoms of this terrible disease. It allows the doctor to prescribe higher doses of L-dopa without the nausea. And the sooner you start the treatment, the better.

Even better, start taking amino acids before you develop the disease. We’ve all had exposure to neurotoxic pesticides. And many of us struggle to digest protein effectively. Taking amino acids can help with both of these treatments. I’ll have more on protein digestion in future issues. But for now, know that amino acids can work wonders with Parkinson’s disease. It has been used successfully in treating Parkinson’s and other neurodegenerative disorders. If you have Parkinson’s, make sure you work with a physician who knows how to use amino acid treatment, as the L-dopa dosages need to be individualized to your situation.

End of article
I recommend Dr. Wesleybeth Reiss if you are in the Long Island area.
If you are not, message me for a list of doctors.
For younger folks into prevention I recommend this product.

For older folks who are looking for muscle benefits, digestion, sleep aid I recommend this product.




Why We Need To Take Vitamin D


Approximately 50% of U.S. citizens are Vitamin D deficient. The numbers are higher among hispanic and black populations.  The melanin in darker-skinned people interferes with the synthesis of the vitamin D that starts at the level of the skin when the sun comes into contact with it. Therefore, darker-skinned people tend to be more deficient. Vitamin D is crucial for good health, and may be one of the simplest solutions to a wide range of health problems, from diseases of the eyes to the bowels, and conditions rooted in chronic inflammation and immune dysfunction in particular. It is a common deficiency worldwide, even in sundrenched areas, yet many people, including physicians, are unaware they may be lacking this important nutrient.

Despite its name, vitamin D is actually a steroid hormone, which you get primarily from either sun exposure or supplementation, along with some foods. Many of its health benefits are due to its ability to influence genetic expression. Unfortunately a large percentage of people have a genetic SNP in their vitamin D receptor.  (I found science showing 59% in the Indian population alone.)

What is a Genetic Polymorphism or SNP (single nucleotide polymorphism)?

All of us have small differences in the information that our DNA contains, and it’s these differences that make each of us unique. Gene polymorphisms are slight changes in the genetic code that are present in at least one percent of the population or as much as 50% or more.

For example – one genetic “letter” (A, T, C, or G) may be replaced by another. These polymorphisms can lead to different processes in the body, just as altering one letter in a word can completely change its meaning, like MAP or MOP.  Those are very different meanings. When the change affects only one genetic letter, it is called a “single nucleotide polymorphism” (or SNP, pronounced “snip”).

What is SNP

Vitamin D regulates 900 different genes, including methylation. Important genes in the vitamin D signaling system, such as those coding for your receptors (termed VDR for vitamin D receptor) and your enzymes 25-hydroxylase (CYP2R1), 1α-hydroxylase (CYP27B1), and 24-hydroxylase (CYP24A1) can be silenced by DNA methylation. (MTHFR) The point is D is important for methylation as well as supporting health, and auto-immune reactions.

The metabolic pathway leading to the synthesis of active vitamin D involves three reactions that occur in different tissues. The pathway is initiated in the skin with the UV light-mediated cleavage of 5,7,-cholestadien-3β-ol to produce the secosteroid (3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol (vitamin D3). The second step occurs in the liver and is catalyzed by a cytochrome P450 (CYP) enzyme that hydroxylates carbon 25, producing the intermediate 25-hydroxyvitamin D3, which is the major circulatory form of the vitamin. The third and final step takes place in the kidney and involves 1α-hydroxylation by another CYP, producing 1α,25-dihydroxyvitamin D3. This product is a potent ligand of the vitamin D receptor (VDR) and mediates most of the physiological actions of the vitamin.

In plain English your skin can initiate the production of Vitamin D but most of us bath before that process can complete.  Then you might have a polymorphism in CYP2R1, the liver enzyme that is part of the Cytochrome P450 that may not be working efficiently and lastly you could have a polymorphism, VDR compromising some of the physiological actions of Vitamin D.

Vitamin D is a strong immune modulator, (think of it for autoimmune diseases or for SAD (Seasonal Affective Disorder, a type of depression). Combined with probiotics, it can also improve intestinal permeability which reduces pro-inflammatory cytokines. Vitamin D can increase your Natural Killer cells as well as certain infection-fighting T cells. It’s a must, especially in cold winter climates although there is plenty of evidence indicating people everywhere are deficient.

Recent clinical studies show if pregnant mothers get adequate Vitamin D in their diets, the incidents of allergies and asthma in the child will be lower.

Common Gene Polymorphism Predisposes Many to Low Vitamin D Levels

It’s worth noting that a fairly significant portion of the population have a gene polymorphism called CYP2R1, a genetic aberration that prevents your liver from hydroxylating the vitamin D3 into 25-hydroxy vitamin D, which is the major circulating form of vitamin D in your body. In this case, the amount of vitamin D you’d need to take could be extraordinarily high.

“This polymorphism in the gene … [means] vitamin D3 is not getting converted into 25-hydroxyvitamin D very well. As a consequence, people with this gene polymorphism, in some cases, have to take very high doses of vitamin D3 orally to achieve normal levels of 25-hydroxy vitamin D — levels that people like you and I would never take, because it could induce some negative effects.

But you wouldn’t know that [you have this polymorphism] if you never got your vitamin D levels measured. I actually know some people in my close friend network that have this gene polymorphism, and they have to take very, very high levels of vitamin D … I don’t know what the incidence is … [but] in order for anything to be considered a gene polymorphism, it has to be over 1 percent of the population.”

The difference between a mutation and a gene polymorphism is that a mutation is thought to occur randomly. For whatever reason, your mitochondria metabolism isn’t working properly, and it’s dumping all sorts of toxic things that may possibly cause a mutation…

A gene polymorphism is thought to be because of a certain reason…It’s largely thought, at least in the scientific community, that gene polymorphisms occur based on nutrition [and] environment…

If, for example, we live in a part of the world where the selenium in the soil is very, very high, as a population, we could have gotten a gene polymorphism in the gene that lowers our selenium absorption, because we don’t need as much in one dose since we are continually getting it.”

There are 30,000 genes in the human body and vitamin D impacts 3,000 of them.

Moreover, researchers have discovered that vitamin D is involved in the biochemical cellular machinery of ALL cells and tissues in your body. Hence, when you don’t have enough, your entire body struggles to function optimally.


Here is a list of just a few of the conditions science has identified an involvement of vitamin D deficiency.


Dry Eye Macular Degeneration MS Bowel Disease RA
Lupus HIV/AIDS Asthma Depression Skin Problems


If you are taking prescription drugs like statins then cholesterol being a precursor to Vitamin D production, you are likely to be vitamin D deficient if your cholesterol is lowered.

So now we established how important it is, how do we get it efficiently?  I like to quote Dr. Mark Hyman here because people still think they can get everything from food and sunshine. “Maybe if we eat only wild, fresh, organic, local, non-genetically modified food grown in virgin mineral and nutrient-rich soils that haven’t been transported across vast distances and stored for months before being eaten….and work and live outside, breathe only fresh polluted air, drink only pure, clean water, sleep nine hours per night, move their bodies every day and are free from chronic stressors and exposure to environmental toxins, then perhaps they might not need supplements…..”

Video on Vitamin D3 with K2

Here is a scientific study showing supplementation vs skin exposure.


Getting Nutrition In to Your Cells

The study below shows a nutrient in two different forms. The maroon color is the nutrient in an isotonic delivery (similar to an IV with the appropriate salts and sugars added to get the ingredients to the cells asap).

The orange color is the exact same nutrient powder crushed into a tablet.  I think the table speaks for itself.

The delivery system matters.  It matters for bioavailability and it matters for speed.  And if you have genetic snps related to your digestive tract it’s even more important.


Isotonic Vitamin D3 with K2

Vitamin D3 is the best source of Vitamin D and it needs Co-Factors like K2.

Extracts from pomegranate, grape seed licorice, and quercetin may affect bone health in combination with Vitamin D by modulating gene expression relating to bone breakdown and formation.


A clinical study published in Phytomedicine indicates that extracts from pomegranate fruit and grape seed may work by downregulating gene expression, CTSG and TacR1 linked to reduced osteoclast activation. (osteoclasts are cells which break down bone, leading to resorption and weakening).

On the other hand, quercetin and licorice extracts may promote bone formation by upregulating gene expression, BMP-2 and COL1A1, linked to bone and collagen formation while down-regulating genes linked to osteoclastogenesis. (osteoblasts are cells which are responsible for bone formation.)

More on Vitamin D or Flu Shot?

Purchase Vitamin D3 with K2


30% Lower Risk of Cancer with 3 times the RDA of VitaminD3 – 4 year Clinical Study

Evaluation of vitamin D levels in women with carpal tunnel syndrome.

Vitamin D washes off

How do we know how much Vitamin D we make?

Fat cells trap vitamin D

Low Vitamin C, Cancer and Obesity

Vitamin D stimulates the production of mood-elevating serotonin

Vitamin D and skin problems

Irritable bowel, stress fractures, MS, HIV, erectile dysfunction, heart health, cancer, arthritis

Health Conditions in Which Vitamin D plays an important role

VDR in Indian Population

Fundamentals of the Vitamin D Endocrine System

Bone health nutraceuticals alter microarray mRNA gene expression: A randomized, parallel, open-label clinical study
7 Ridiculously Simple Ways to Protect Yourself From Cold and Flu and the 4 No Nos

The Link Between Vitamin D and Autism

Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase

Inflammation and Vitamin D: the infection connection




INFLAMMATION – hot hot hot

Inflammation photo


The secret to a quality of health and well-being?

It’s not vitamins, growth hormone, emotional cleansing, detox, meditation, yoga, tender loving care (TLC) or even exercise. They all help, of course they do!

But it’s pretty clear to doctors who know their stuff what the number one factor is: you need to keep inflammation to an absolute minimum.

Inflammation is an insidious disease process that goes on in all tissues and organs and greatly accelerates change and decay.

Relaxed and efficient tissues and organs perform well but when they are hot and excited, suffering from a cascade of irritating painful chemicals known as inflammatory cytokines (everything quickly starts to break down and the aging process advances rapidly.)

Most of the diseases which are hallmarks of decay and aging have a strong inflammatory component. Cancer, heart disease, arthritis, arteriosclerosis, Alzheimer’s disease and diabetes (yes, you read those last two right)… these are all, essentially, inflammatory diseases.

Inflammation can be caused by allergies, parasites, intolerant substances, chemical pollutants, electrical and magnetic field burdens, microbes (especially hidden chronic infections) and a host of other factors.

And inflammation is cooled down by important nutrients like science based quality omega-3 fatty acids and antioxidants. Now you know why they work!

So What Can We Do?

Reduce the inflammatory load.

There is one very easy and amazingly successful way to do this. You can do it.

If you do it right you’ll look and feel years younger within a matter of months. People will say: “What are you on? I want some!” and You’ll look ten years younger. What is your secret?”

What’s the Big Secret?

It’s eliminating stressor or inflammatory epigenetics (diet, lifestyle, and chemical exposures, environment and how they impact your genes possibly your children and grandchildren).

Now this is NOT the same story as eating right for your type, the blood group diet, food combining or acid vs. alkaline foods, plant based, vegan OR ANY OTHER DIET “THEORY” although many of those matter too but YOU are unique.  This is about your genetics and your environment and using science-based solutions not marketing based-solutions.

This is about working out your own personal UNIQUE anti-inflammatory lifestyle based on YOUR genetics.

 How Can I Find Out My Genetics?

The Human Genome Project, a $3-billion project was formally founded in 1990 by the US Department of Energy and the National Institutes of Health and from that the world has changed.  The future is genetics and it is moving like a rocket ship.

Lots of people are buying genetic kits like 23AndMe,, and every day new companies come to market to get a piece of this amazing pie.  Most of them do it so they can use your DNA for clinical studies.  There is nothing wrong with that and we need that but seriously why don’t they just pay you for it?

Sure they give you information BUT if you believe it won’t get into the hands of insurance companies and others who will discriminate against you (and yeah I know it is against the law) but seriously if you believe the law will protect you, I have a bridge I can sell you in Brooklyn.  You need to make sure the kit you buy is science based and they destroy your DNA without selling it to anyone.

I like to work with a genetic scientist named Keith Grimaldi who worked with Dr. Walter Gilbert, Nobel Laureate in DNA on the Human Genome Project and helped to develop the first lifestyle screening.  For as long as I’ve known him, which is since 2005, he has the highest integrity and so do the companies he works with. He won’t put a genetic SNP in his screening unless he has the science – 3 independent clinical studies proving if you change your lifestyle, you can change the expression of your DNA.

In all fairness, that’s just not true for other companies.  They put SNPs in without that kind of scientific verification.

It is the FDA’s job to monitor that but honestly, they just can’t keep up so these days we all have to be our own grassroots activist.

Your doctor most likely won’t even have any training on this unless your doctor makes it a priority (but there are health professionals who do make it a priority).

Most doctors are just keeping their head above water.  (In the U.S. they still don’t even tell their patients to take CoQ10 when they give them a statin even though it is in the literature and they’ve been packaging it together for over a decade in Europe.  That one is for you Dave.)

So Now I know My Genetics, What is a SNP (single nucleotide polymorphism)?

What is SNP

All of us have small differences in the information that our DNA contains, and it’s these differences that make each of us unique. Gene polymorphisms are slight changes in the genetic code that are present in at least one percent of the population or as much as 50% or more.

For example – one genetic “letter” (A, T, C, or G) may be replaced by another. These polymorphisms can lead to different processes in the body, just as altering one letter in a word can completely change its meaning, like MAP or MOP.  Those are very different meanings. When the change affects only one genetic letter, it is called a “single nucleotide polymorphism” (or SNP, pronounced “snip”).


What Are the Genetic SNPs related to Inflammation?

There are lots but remember we are looking at the ones that we KNOW you can change by changing your lifestyle.

Inflammation SNPs

What Can I DO?

Change your lifestyle and environment.  Start with what you eat.  You need to eat organic, mostly plant based and you need meat and eggs in my opinion.  Cut out simple carbs and eat less grains but this will all be different for different people; based on their genetics.



Eliminate all processed foods that contain synthetic folic acid.  Eat Organic.  Avoid any unnecessary toxins to offset expression of SOD2 and other genes.

Eliminate flour, grains as much as possible.  Sometimes it is OK but there are genes that put you at risk for celiac problems.

Eliminate endocrine disruptors.  Replace plastics with glass.  Replace Teflon pans with stainless steel and other non-toxic substances. Install a whole house water filter.

Yeah I know it isn’t easy but at the risk of exposing my age my childhood had NONE of that stuff.


Regular exercise makes your body release endorphins, which help to reduce pain and make you feel much better. So much so that exercise is now being used as a treatment for depression in some places.
In my case a low carbohydrate diet is recommended because of my very high genetic sensitivity to carbs. Managing weight is important.
Overweight is a “pro-inflammatory” condition.  I’m a big fan of lifestyle changes NOT diets.  A diet by its very definition won’t work because you go “on” and “off.”  If you don’t change lifestyle, you will gain the weight back when you stop dieting.  And yo yo dieting is the worst thing you can do for cardiovascular health.  Transitions Lifestyle System, TLS has every component demonstrated through science that helps people reach their ideal weight and most importantly, STAY THERE. It is realistic as it has a quiz built in asking the individual their goals and what they are willing to do and then recommending a plan they can stick to.


Everyone MUST supplement.  Dr. Mark Hyman says it best, “Maybe if we eat only wild, fresh, organic, local, non-genetically modified food grown in virgin, mineral and nutrient-rich soil that has not been transported across vast distances and stored for months before being eaten……AND work and live outside, breathe only fresh unpolluted air, drink only pure clean water, sleep nine hours per night, move the body every day, are free from chronic stressors and exposure to environmental toxins, then perhaps we might not need supplements.”

We still burn coal for energy and the by-product of burning coal is methyl-mercury.  We breathe it, it goes into our soil when it rains and it impacts (especially) root vegetables.  It goes into our water systems and impacts everything in those systems that we consume.

We’ve polluted our air, water and soil with herbicides, pesticides, chemicals and pharmaceuticals.  For example a kind of plastic, BPA will cause an increase in blood pressure.  There is almost 300,000 tons of it in the ocean alone.  We use plastics for everything now.  We should stop using plastics and Teflon coated items for food preparation and storage.

Getting Nutrition Into Your Cells

The study below shows a nutrient in two different forms. The maroon color is the nutrient in an isotonic delivery (similar to an IV with the appropriate salts and sugars added to get the ingredients to the cells asap).

The orange color is the exact same nutrient powder crushed into a tablet.  I think the table speaks for itself.

The delivery system matters.  It matters for bioavailability and it matters for speed.  And if you have genetic snps related to your digestive tract it’s even more important.


Omega III

It is not safe to eat fish high in fat; maybe Wild Alaskan Salmon (but then you have to deal with issues like the retailers are mislabeling so they can charge more money and regulators can’t keep up). Senator Whitehouse of RI gave a speech on the state of the oceans.  His wife is a marine biologist for the Obama Administration.  In the speech he said that the ocean is toxic.  He said when a whale beaches up on the shores of RI it is considered toxic waste.  The other problem is there is tons of plastic in the ocean.  Plastic can cause high blood pressure and other problems if consumed.  It is an endocrine disruptor. The fish are eating the plastic and tiny bits of it are showing up in their bodies and then you eat them.

Because it is critical to consume fatty-ocean products, Omega III are an alternative.  You can learn more here. It’s also critical we clean up the ocean and stop polluting it.

Omega III is a very important nutritional product for everyone. Not all Omega III are the same.  Not all Omega III have EPA and DHA in the combinations science shows are most effective and have tocotrienols to increase their impact.  They need to have sardines and anchovies from the most remote parts of the ocean, they need to remove any trace of toxins multiple times.  I like them to follow sustainable practices.  (And no I’m not satisfied that krill oil can do the same.) They won’t be cheap.

If they are, you are consuming toxic waste and wasting your money.


 High-quality probiotics will improve the quality and count of your healthy disease-fighting bacteria.  Some strains will even induce IL-10-producing regulatory T cells which is a scientific way of saying they reduce inflammation, and can help immune function as well as inflammatory disorders of the gut like painful Crohn’s and Ulcerative Colitis.


As of 2015, there are 1149 scientific studies on antioxidants in  They work.  They scavenge free radicals that cause inflammation and repair cells.  I like people to have a custom cocktail with a combination of oxygen and nitrogen free radical scavengers:

Grape Seed Extract is typically extracted from the seeds of red grapes which have a high content of compounds known as oligomeric proanthocyanadins (OPCs).  Grape seed extract is extremely rich in polyphenols, compounds with high antioxidant activity.  Many of the clinical studies examining the damage of fluoroquinolones identify oxidative stress as the underlying mechanism of their toxicity.

Red Wine Extract (Resveratrol) is a powerful antioxidant.  This extract is found in grape vines, roots, seeds and stalks, with the highest concentration in the skins.  The antioxidant properties of red wine extract contribute to maintaining healthy circulation by strengthening capillaries, arteries and veins, and promoting overall cardiovascular health.  It is also known to activate the SIRT1 gene, better known as the longevity gene.  The only other known way SIRT1 is activated is by a lifestyle of caloric restriction.

In the late 1990’s, scientists took note of a phenomenon among the French.  There were very low rates of cardiovascular problems in the provinces where residents consistently ate high fat foods and drank red wine.

Scientists concluded that the protective properties of red wine have helped the French maintain cardiovascular health for years and subsequent scientific studies have further shown that the OPCs found in red wine are particularly beneficial for protecting the heart and blood vessels.  There are also clinical studies showing resveratrol is protective of corneal endothelia.  Fluoroquinolones damage corneal endothelia and inhibit regrowth and repair.

Pine Bark Extract (Pycnogenol®) is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne.  This unspoiled and natural forest environment is the unique source of pine bark.  Pycnogenol is one of the most researched ingredients in the natural

Product marketplace.  Published findings have demonstrated Pycnogenol’s wide array of beneficial effects on the

Body.  Pine bark extract is an all-natural combination of procyanidins, bioflavonoids and organic acids.

The extract has three basic properties – it is a powerful antioxidant, selectively binds to collagen and elastin, and promotes the normal production of endothelial nitric oxide, which promotes the normal dilation of blood vessels.

As one of the most potent natural scavenger of free radicals, Pycnogenol combats many aggressive free radicals before they cause oxidative stress to vital organs.  Its super=antioxidant capabilities help support healthy blood platelet activity, support healthy blood glucose levels, reduce mild menstrual cramping and abdominal pain, maintain joint flexibility, promote cardiovascular health, promote healthy sperm quality, maintain healthy cholesterol levels and support a healthy complexion.

Bilberry extract is derived from the leaves and berry-like fruit of a common European shrub closely related to the blueberry. Extracts of the ripe berry are known to contain flavonoid pigments known as anthocyanins, which are powerful antioxidants. Scientific studies confirm that bilberry extract supports healthy vision and venous circulation. Bilberry extract helps maintain healthy circulation by strengthening capillaries, arteries and veins.

Bioflavonoids are antioxidants found in certain plants that act as light filters, which protect delicate DNA chains and other important macromolecules

by absorbing ultraviolet radiation. They have been found to promote cardiovascular health, help maintain healthy circulation by strengthening capillaries, arteries and veins , and demonstrate anti-inflammatory activity.

Cranberry is a small evergreen shrub containing dark pink flowers that grows in damp bogs and mountain forests. It blooms from late spring until the end of the summer. The shrub’s small red fruits are produced in the fall. The therapeutic properties of the plant come from the fruit. Cranberries contain proanthocyanidin, which are helpful in promoting a healthy urinary tract and supporting a normal pH of urine. Preliminary evidence suggests that cranberries increase the antioxidant levels of plasma and may help maintain healthy cholesterol levels by providing antioxidant protection of LDL particles.   Cranberries have a high ORAC value, next to blueberries.

Blueberries rank highest among many fruits and vegetables for ORAC activity and contain 25-30 different types of anthocyanins. Anthocyanins give blueberries (and other fruits) their rich blue and red coloring, and are a powerful flavonoid antioxidant. The mechanism of action surrounding anthocyanins has been studied at the molecular level, demonstrating effects such as promoting cellular health. Blueberries provide large amounts of chlorogenic acid, which is thought to be important in promoting cellular health. Blueberries support the body’s COX-2 inhibitors and provide a powerful antioxidant defense, supporting a strong, comprehensive antioxidant network within the body.

Grapes contain a variety of phenolic compounds, including anthocyanidins, cinnamates and flavan-3-ols, which have all been shown to be effective in promoting cardiovascular health. Anthocyanidins are powerful flavonoid antioxidants that contribute to maintaining cellular health. Preliminary evidence suggests that anthocyanidins contribute to supporting healthy capillaries and providing antioxidant protection of LDL particles, which help to maintain healthy cholesterol levels and contribute to overall cardiovascular health.

Raspberries contain significant amounts of polyphenol antioxidants, chemicals linked to promoting endothelial and cardiovascular health. Raspberries are high in fiber, are an excellent source of vitamin C and manganese, a good source of vitamin K and magnesium, and contain some calcium and iron.

Raspberries are powerful antioxidants, particularly due to their dense contents of ellagic acid (from ellagotannins), quercetin, gallic acid, anthocyanins, cyanidins, pelargonidins, catechins, kaempferol and salicylic acid. They have a high ORAC value next to cranberries and blueberries.

Elderberries contain the flavonoids rutin, isoquertin and hyperoside, as well as anthocyan glycosides, an essential oil. Elderberries have historically been used to make elderberry wine, elder brandy, and sambuca, a popular cordial. Elderberries have a high ORAC value, and contribute to promoting a comprehensive antioxidant network and stimulating the immune system.

Black Currants are powerful antioxidants, particularly due to their anthocyanins content. They are rich sources of vitamin C, and contain high concentrations of B-vitamins, vitamin A, potassium, magnesium, iron, and calcium. Black currants have a high ORAC value. They contribute to promoting a comprehensive antioxidant network, stimulating the immune system and promoting cardiovascular health.

Pomegranate Extract
One pomegranate delivers 40 percent of an adult’s daily vitamin C requirement, and is a rich source of folic acid and antioxidants. Pomegranates are high in polyphenols. The most abundant polyphenols in pomegranate are hydrolysable tannins, particularly punicalagins, which research has shown to be the antioxidant responsible for the free-radical scavenging ability of pomegranate juice. Many food and dietary supplement makers have found the advantages of using pomegranate extracts (which have no sugar, calories or additives), instead of the juice, as healthy ingredients in their products. Many pomegranate extracts are essentially ellagic acid, which is largely a by-product of the juice extraction process. Ellagic acid has been shown in published studies to absorb into the body when consumed as ellagitannins, such as punicalagins.

Plum Powder contains several powerful antioxidants, with a high ORAC content. They are rich sources of many essential vitamins and minerals.  They are also rich in dietary fiber, sorbitol and isatin. They have been commonly used to promote digestive health, but also contribute to a comprehensive antioxidant network, promote cognitive health and cardiovascular health.

Chokeberries are powerful antioxidants due to their high anthocyanins content. They are rich in vitamins and minerals, and contribute to general health and well-being. They contribute to a comprehensive antioxidant network, scavenging free radicals and promoting antioxidant protection of LDL particles.

Bioperine® is a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper). It contains 95 percent of piperine. The metabolic process that generates energy at the cellular level in the human body is called thermogenesis. Though thermogenesis has been identified as a key factor in maintaining weight loss, it has also been identified as playing an integral role in utilizing the daily food and nutrients that the human body consumes.

It sets in motion the mechanisms that lead to digestion and subsequent gastrointestinal absorption. Piperine, in the patented form of Bioperine®, promotes the body’s natural thermogenic activity. Bioperine enhances the bioavailability of certain nutrients, especially antioxidants.

Vitamin C is found in peppers (sweet, green, red, hot red and green chili), citrus fruits, brussels sprouts, cauliflower, cabbage, kale, collards, mustard greens, broccoli, spinach, guava, kiwi fruit, currants and strawberries. Nuts and grains contain small amounts of vitamin C. It is important to note that cooking destroys vitamin C activity. Vitamin C is integral in supporting a healthy immune system, promoting cardiovascular health, maintaining healthy cholesterol levels and providing an antioxidant defense. The body does not manufacture vitamin C on its own, nor does it store it. Therefore, vitamin C must be acquired through diet and supplementation.

Vitamin E (Natural tocopherol: d-gamma 70%, d-delta 21%, d-alpha 7%, d-beta 2%): is a collective term for a group of compounds from the tocopherol and tocotrienol chemical groups. The most valuable sources of dietary vitamin E include vegetable oils, margarine, nuts, seeds, avocados and wheat germ. Safflower oil contains large amounts of vitamin E (about two thirds of the RDA in ¼ cup), and there are trace amounts in corn oil and soybean oil. Vitamin E is available in a natural or synthetic form. In most cases, the natural and synthetic forms are identical except the natural form of vitamin E is better absorbed and retained in the body. For those individuals watching their dietary fat consumption, which is relatively common in the world of dieting, vitamin E intake is likely to be low, due to a reduced intake of foods with high fat content. The main health benefit of supplemental vitamin E comes from its immune-boosting antioxidant activity. It is also known to provide protection for the cardiovascular system.

Vitamin E is one of the most powerful fat-soluble antioxidants in the body. In turn, vitamin E protects cell membranes from free radicals.  (Most oils are GMO these days and are Omega 6 which is much too abundant in the American diet.)  I prefer a high quality supplement that doesn’t use GMOs.

The combination of vitamins C and E helps form the antioxidant network, allowing the vitamins to engage (synergistically) in each others’ regeneration from the spent state back to the active antioxidant state so that they can continue neutralizing free radicals.

Tocotrienols (mixed isomers)
Palm tocotrienols, along with tocopherols, are members of the vitamin E family and are extracted from the fruit of the palm tree. Tocotrienols are one of the two related families of compounds that are collectively regarded as vitamin E. As mentioned above, vitamin E is one of the most powerful fat-soluble antioxidants in the body, and the antioxidant properties of tocotrienols appear to be superior to those of tocopherols. Dietary sources of tocotrienols include almonds, rice bran oil, pistachios, palm oil and barley. Like vitamin E, palm tocotrienols also help maintain a healthy level of HMG-CoA reductase, a key enzyme in our bodies used by the liver to produce cholesterol. New data on the biological activity of tocotrienols in cardiovascular health maintenance along with its antioxidant properties have raised tocotrienols to a new level of prominence in the scientific community.

Lutein and Zeaxanthin are carotenoids found together in many fresh fruits and vegetables. Within the eye, they are found as pigments in the macula and retina. Lutein and Zeaxanthin act as antioxidants to protect the eye from free radical damage. They help to build macular pigment density, a critical factor in the health of the macula and retina in relation to the clarity of the lens. They also act as filters of blue-light to protect the photoreceptor cells of the retina from light damage. Blue-light wave lengths can generate free radical damage.

Eyebright® is an annual plant with deeply-cut leaves and small, white or purple flowers variegated with yellow, native to Great Britain. There are over 20 species of eyebright that extend over Europe, Northern and Western Asia, and North America. The medicinal portion of eyebright comes from fluid extracted just above the root only when the plant is in bloom.

Eyebright is used for the inflammation of the eyelids, sties and eye fatigue. Eyebright has been used by herbalist since the 16th century for problems of the eyes.

Copper may have some antioxidant properties and acts as a component of enzymes in iron metabolism. It is an essential trace mineral. Copper is needed in normal infant development, iron transport, bone strength, cholesterol metabolism, myocardial contractility, glucose metabolism, brain development and immune function.

Zinc is a component of multiple enzymes and proteins. It is also involved in the regulation of gene expression. Zinc is an essential trace mineral that has functions in approximately 300 different enzyme reactions. Thus, zinc plays a part in almost all biochemical pathways and physiological processes. More than 90 percent of the body’s zinc is stored in the bones and muscles, but zinc is also found in virtually all body tissues. It has been claimed that zinc plays a role in wound healing, immune system support, promoting a healthy prostate gland and supports healthy sperm quality. Because zinc is involved in such a great number of enzymatic processes, it has been found to positively affect a large range of functions, including digestion, energy production, growth, cellular repair, collagen synthesis, bone strength, cognitive function and carbohydrate metabolism.

 Quercetin® is a bioflavonoid that is an excellent antioxidant working synergistically with vitamin C to strengthen the walls of the intricate blood vessels in the eye. It also helps to maintain lens transparency. Quercetin has been shown to inhibit the enzyme, aldose reductase. Aldose reductase has been known to contribute to poor eye health.

L-Taurine is a building block for all the other amino acids. It aids in the transport of potassium, sodium, calcium and magnesium in and out of cells, thus helping to generate nerve impulses. It is a non-protein amino acid and is found in high amounts in the brain, retina, myocardium, skeletal and smooth muscle, platelets and neutrophils. It is plentiful in the fluids of muscle, lungs and nerve tissue. It is classified as an essential amino acid and aids micelle formation and fat absorption. Further, it promotes alertness, mental energy and focus.

Taurine also has antioxidant and membrane-stabilizing activities. It may also help maintain a healthy cardiovascular system while also delivering detoxifying activities. It helps protect the eyes from the harmful effects of UV light and stabilizes the membranes in the cones cells of the eye.

It also supports healthy cholesterol and blood pressure levels. It may also help maintain a healthy cardiovascular system while also delivering detoxifying activities.*

Lycopene is one of the carotenes and a member of the carotenoid family. Lycopene offers a wide range of benefits in helping maintain healthy cardiovascular health, prostate health and powerful antioxidant. More recent research suggests that lycopene, like beta-carotene, may play an important role in keeping vision healthy by preventing cataracts and Age-Related Macular Degeneration (AMD).

Activated B-Complex® With Quatrefolic – People with MTHFR polymorphisms need active ingredients especially folate. Some of the bodily functions that need support of B-complex are nervous system, digestive system, cardiovascular system, skin health, mitochondrial health and cognitive health.  They are easily depleted by our environment, especially prescription medication.

I recommend purchasing from, the only legitimate distributor of science based, isotonic nutrition.  There are many dubious knock offs, possibly adulterated and expired on other sites so caution advised.



Training, Competition and Genetics


The regular demands of training and competition make professional, collegiate, and recreational athletes highly susceptible to injury.

Genetics have a large influence over strength, muscle size and muscle fiber composition (fast or slow twitch), anaerobic threshold (AT), lung capacity, flexibility, power and endurance.

Injury is a fact of life for most athletes, but some professionals—and some weekend warriors —just seem more injury-prone than others. But what is it about their bodies that makes the bones, tendons, and ligaments so much more likely to tear or strain—bad luck, or just poor preparation?

A growing body of research suggests another answer: that genetic makeup may play an important role in injury risk.

Recreational distance running causes high numbers of injuries, with incidence rates estimated between 30% and 75% per person per year.

Treatment of sports injuries costs at least $160 billion per year in the U.S. and Major League Baseball lost $1.6 billion in payroll between 2008 and 2013 because of injuries to players. Avoiding injuries and remaining healthy is key to the success of a team or an individual athlete.

The potential to use genetic testing to reduce sports injuries



The COL1A1 gene, for example, encodes the alpha chain of type I collagen, the major protein component of all tendons and ligaments.  It’s associated with vasodilation, blood pressure control, efficiency of muscular contraction and cell hydration.

The GT alleles have a moderately raised risk of tendon and ligament injuries in sport. They need to undertake pre-habilitative exercises relevant to the sports they participate in and consider nutritional support for connective tissue.  They will have reduced response to endurance training and should make sure they stay sufficiently hydrated during endurance activities.

The GG will have an increased risk for tendon and ligament injuries and ruptures and or shoulder dislocations especially related to sports participation. They should also undertake pre-habilitative exercises relevant to the sports they participate in and consider nutritional support for connective tissue. They will have reduced response to endurance training and should make sure they stay sufficiently hydrated during endurance activities.

The TT variants contribute to positive response to endurance training.  They are positive for increased muscle efficiency especially in conjunction with ACE I-allele.  The T allele leads to increased expression of type I collagen alpha polypeptides compared with the G nucleotide, which may increase the tensile strength of tendons and ligaments. About 4% of athletes carry 2 copies of the T allele.

(90% of people who have brittle bone disease have mutations in COL1A1 and COL1A2.  I’m sure these folks would have liked to know early on so they could have taken preventive measures.)

Besides polymorphisms in COL1A1, there are additional DNA variants associated not only with ACL rupture and Achilles tendinopathy but also with other athletic injuries (shoulder dislocations and muscle strain severity).  It is important to note here that there are antibiotics that can flox genes and cause serious injuries, ruptures of the Achilles tendons and other tendons and even disability.  To learn more about fluoroquinolones like Cipro and Levaquin click here.  (Pharmacogenetic screenings can identify contraindication with prescription medications.)

The gene COL5A1 encodes the protein collagen alpha-1(V) chain. It is a minor connective tissue component but of ubiquitous distribution.  Type V collagen binds to DNA, heparin sulfate, thrombospondin, heparin, and insulin.  Defects in COL5A1 are a cause of Ehlers-Danlos syndrome (EDS1).


A functional skeletal system requires the coordinated development of many different tissue types, including cartilage, bones, joints, and tendons. Members of the Bone morphogenetic protein (BMP) family of secreted signaling molecules have been implicated as endogenous regulators of skeletal development. This is based on their expression during bone and joint formation, their ability to induce ectopic bone and cartilage, and the skeletal abnormalities present in animals with mutations in BMP family members. One member of this family, Growth/differentiation factor 5 (GDF5).



IL-6 mutations can be involved with other mutations like CRP and TNF in autoimmune disorders like Epstein Barr if the athlete has the mutation and is overtraining.

IL-6R is associated with immune response and cell growth. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.


C-Reactive protein (CRP) is associated with acute phase protein and rises in response to inflammation in the body.  Elevation in CRP concentration will aid in determining the severity of acute tissue injury.


The genetic variant Tumor Necrosis Factor (TNF) causes over-inflammation. There is data suggesting that TNF may exacerbate neurobehavioral deficits and tissue damage.  If an athlete is over-training it could be involved in autoimmune disease.

Acute traumatic joint injury increases the risk of developing osteoarthritis.  Elevated levels of TNF and IL-6 have been detected in joint injuries.

There are separate studies concerning genetic polymorphisms associated with athletic performance, such as muscle contractility and V̇O2 max. Genetic information of this sort has recently been used to prevent injuries and maximize athletic performance. A professional soccer team in the English Premier League, for example, tested athletes for genetic loci associated with sports performance, and the English Institute of Sport expressed interest in providing genetic testing to Britain’s Olympic athletes in 2012.

The future holds promise for everyone. Someone with limited genetic potential can find ways to compensate and become a solid performer and athletes who are lucky to have exceptional genetics can optimize them.

Trainers and professionals can use this information to help optimize their clients and patients.

I think this is the best genetic lifestyle screening on the market because of the genetic scientist behind it, Dr. Keith Grimaldi.  I know his integrity and ethics.  He will not put genes in his screening that haven’t been tested with 3 independent clinical placebo studies proving a change in genetic expression influenced by a change in lifestyle.

If you would like to integrate this screening into your practice to improve patient outcomes, I’d be happy to offer you a complementary proposal.  Contact me at or 617.515.7559.

If you would like to use this screening to develop an action plan for your own optimal health, I’d be happy to offer it to you with my complementary services for a review of results.  Contact me at or 617.515.7559.


Why Genetic Lifestyle Screening Can Make a Difference

General Timeline of Genetic Training in Sports

1966 – 1991 Y-chromosomal testing as part of official sex segregation.
2001 Policy of the International Association of Athletics Federations and of the International Olympic Committee, respectively.
2001 Professional Boxing and Martial Arts Board of Victoria considers compulsory genetic screening for APOE4 variant in boxers.
2003 World Anti-doping Agency prohibits methods of gene doping.
2005 Eighteen Australian male rugby players were tested and analyzed for 11 genes.

The Chicago Bulls attempt genetic testing of free agent, Eddy Curry, for the purpose of ruling out hypertrophic cardiomyopathy.

2009 23andMe analyzes DNA samples from 100 current and former NFL linemen.

Major League Baseball begins using genetic testing with prospective players from the Dominican Republic and other Latin American Countries.

2010 The National Collegiate Athletic Association implements mandatory sickle cell trait screening.
2011 An English Premier League soccer team analyzes players’ DNA samples at 100 genetic loci.

The National Football League screens for genetic conditions sickle cell trait and G6PD under the 2011 NFL collective bargaining agreement.

2012 2012 English Institute of Sport expresses interest in the integration of genetic technologies to “tailor the training, conditioning, and preparation” of Britain’s Olympic and Paralympic athletes.
2014 Two Barclay’s Premier League soccer teams commission tests of their players’ DNA for 45 variants.

Why We Should Eat Organic

Genetically Engineered Photo

Genetics, Genetically Engineered Food and Human Health 101


Exciting developments in genetics have led to all kinds of amazing, promising and dramatic potential in the future.  Unfortunately the opposite can also happen.  It is up to us to determine the ethics and regulation of this new industry.

What is GMO?

Genetically engineered (GE) foods, sometimes referred to as genetically modified foods (GMO foods), are foods that are derived from scientific methods used to introduce new traits or characteristics to an organism. They have become very controversial. The labeling of GE foods has been the subject of debate among members of the general public and federal and state governments since the introduction of GE foods to the food supply in the 1990s.

What is BT Toxin?

Bt (Bacillus thuringensis) is a bacterium used as a biological pesticide. Monsanto uses this in its GE seeds. It is called Cry1Ab and Cry1AC and injected into the DNA of genetically engineered seeds. The idea is that insects eat it and explode from the inside out. The Bt toxin dissolve in the high pH insect gut and become active. The toxins then attack the gut cells of the insect, punching holes in the lining. The Bt spores spill out of the gut and germinate in the insect causing death within a couple days. Of course when it filed its application to do this with the FDA Monsanto claimed this is completely safe for humans.  And by the way most of the studies they submitted to prove this were funded by them.

Now just stop for a second and ask yourself something.  If you eat just a tiny bit of something numerous times a day every day for your entire life that makes an insect explode from the inside out, does it make any sense to you that it is completely safe for you? Science or no science.  OK but if you must have the science check the end of this article for the clinical studies. Not only do these cry-toxins target the kidney cells of developing human fetuses, but when Cry1Ab and Cry1Ac are combined with RoundUp, they can delay the body’s ability to eliminate human cancer cells. (Called apoptosis.)  Some independent sources claim the FDA gave Monsanto an indefinite hall pass to cause mayhem on the food supply.

The UK has done clinical studies on pregnant mothers and found BT toxin and glyphosate in their microbiome (gut) and BT toxin and glyphosate in the newborn’s microbiome, essentially turning the human gut into a pesticide factory.

New research from Canada shows it can kill a human embryo. What’s worse, glyphosate, the main ingredient in RoundUp, also causes necrosis – i.e. the death of human tissue.

What is Glyphosate?

Glyphosate, the active ingredient in Roundup®, is a Monsanto product and used worldwide.  It is the most popular herbicide and technically patented as an antibiotic. (That is another discussion because of its possible contribution to antibiotic resistance.) About 100 million pounds are applied to U.S. farms and lawns every year, according to the EPA.

GE companies have argued for decades that GE foods will reduce the use of pesticides and herbicides.

However, the science is showing the exact opposite.  In a 2014 study titled “Compositional Differences in Soybeans on the Market: Glyphosate Accumulates in Roundup Ready GM Soybeans.” The authors specifically conclude that nutritional and elemental variables “without exception” demonstrate “substantial non-equivalence” between GM soy and non-GM varieties. With the advent of Roundup Ready crops, use of glyphosate has significantly risen, with about 1 billion pounds sprayed on crops every year.

The industry asserts it is minimally toxic to humans. However, residues are found in the main foods of the Western diet, comprised primarily of sugar, corn, soy and wheat.

A 2009 study found that Roundup’s inert ingredients amplified the toxic effect on human cells—even at concentrations much more diluted than those used on farms and lawns.

One specific inert ingredient, polyethoxylated tallow amine, or POEA, was more deadly to human embryonic, placental and umbilical cord cells than the herbicide itself – a finding the researchers call “astonishing.”

Glyphosate’s toxicity is well established, with adverse health effects ranging from birth defects to endocrine dysfunction to cancer. Unbelievably, the U.S. Department of Agriculture (USDA) admits foods are not tested for glyphosate residues due to the high cost of doing so.

However, GE crops are much more heavily contaminated with glyphosate than conventional crops by nature of their very design, and this fact alone blows a massive hole in the safety claim.

Glyphosate was recently classified as a Class 2A “probable human carcinogen” by the International Agency for Research on Cancer (IARC), a division of the World Health Organization (WHO).

Roundup has also been found to interfere with ATP production by affecting your mitochondrial membranes. In this case, it’s actually the so-called “inert” solvents in Roundup that pose the greatest threat.

However, when you add the solvents and glyphosate together, the solvent makes the membrane more permeable, allowing the glyphosate to enter. Without the solvent, the damage might not be as great.

The chemical also wasn’t supposed to accumulate in the human body, but this too has been shown to be a false assumption.

Glyphosate chelates manganese (plus many other minerals), which makes the plants deficient. In turn the animals or humans who eat the plants do not get enough either.

It’s worth explaining the chelation process a bit further. As Smith notes, glyphosate binds very strongly to micro minerals, and doesn’t let them go.

So even if there’s manganese in the plant you eat, your body cannot access and use it, because the glyphosate molecule holds it trapped within itself. Likewise the plant is prevented from taking up the mineral, even if it’s in the soil.

Your mitochondria require manganese to break down superoxide dismutase (SOD) and turn it into hydrogen peroxide, which is far less toxic, and eventually water. This is a very important process, as it protects your mitochondria from oxidative damage. Without manganese, this protection is lost. (And if you have a polymorphism in the gene that makes the enzymes , like SOD2, there will be more side effects.)

Even in the midst of mounting questions about glyphosate’s safety, the Environmental Protection Agency (EPA) raised the allowable limits of glyphosate in our food and feed crops back in July 2013. Allowable levels in oilseed crops such as soy were doubled, from 20 ppm to 40 ppm. Permissible glyphosate levels in many other foods were raised to 15 to 25 times previous levels.

Root and tuber vegetables, with the exception of sugar, got one of the largest boosts, with allowable residue limits being raised from 0.2 ppm to 6.0 ppm. The level for sweet potatoes was raised to 3 ppm.

Why would the EPA raise the allowable levels with all this evidence of danger to human health? At the risk of tons of spam, the answer is Capitalism.  As much as people hate to hear the word Socialism in the U.S. the downside of Capitalism is that corporations using highly paid lobbyists are determining the health of U.S. citizens and creating all kinds of misinformation in the world.  Their job is to obfuscate.  Countries like Denmark have the highest health and well-being in the world because their primary objective is an enlightened, healthy society, instead of the primary objective being making money.

One of the exciting, positive developments in genetics is lifestyle genetics.  Ordinary people can now test their own DNA to determine how they will react to things like drugs, toxins and GE foods.

Here are my results.  Each of the SNPs in this test have been clinically tested and proven three times that I can change the expression of my DNA by changing my lifestyle.


That is so amazing isn’t it?  Changing my environment in my home is not that difficult but outside my door in the U.S. not so much.

What is Cytochrome P450?

If you want to understand how different people vary in their response to drugs and toxins that have entered their body, you have to know something about cytochrome P450. It is possible that doctors in the USA alone may kill about one hundred thousand people per year through drug interactions.  We have no indication that in other western countries this figure is lower.

CYP is a host of enzymes that use iron to oxidize things, often as part of the body’s strategy to dispose of potentially harmful substances by making them more water-soluble.  Researchers found back in 1997 that 56% of 315 drugs were primarily cleared by CYP!

Families are numbered – for example CYP2, CYP21.  Subfamilies are identified by a letter, CYP3A, CYP2D. Individual genes are identified by a number, for example CYP1A21F and CYP1A1.

CYP1A1 alters susceptibility to oxidative brain damage.

There are over a thousand different CYPs, although the number in humans is only about fifty. The liver contains an enzymatic pathway called Cytochrome P450 1A2 (CYP1A2) that detoxifies many compounds including caffeine.

CYP1A2 codes for a Cytochrome P450 enzyme that is involved in Phase I (activation) of removing toxins, such as carcinogens from food and smoke, it also metabolizes caffeine. Interactions have also been reported for the vitamin D receptor (VDR) which may affect the influence of caffeine on bone mineral density.

There is an association between coffee consumption, CYP1A2*1F genotype, and breast cancer characteristics.

The rapid version (AA) activates more rapidly potentially toxic substances present in meat cooked at high temperatures.  I have this rapid version.


Taking Birth Control or Hormone Replacement? It’s a problem if you have a SNP in cytochrome P450 enzyme system. In particular, CYP1B1 or CYP1A2, which slows down the breakdown of toxins (xenobiotics like fake estrogens) causing them to build up in your system and increasing risk of breast and ovarian cancer.

I couldn’t take birth control pills for very long because they caused me to have blood clots.

(Avoid fluoroquinolone drugs and other prescriptions if you have a SNP in CYP1A2 (like me) because these drugs are strong inhibitors of the gene and the drug will build up quickly.  You don’t want to get yourself “floxed” trust me! So unless you have a life-threatening infection, I’d avoid ciprofloxacin, levofloxacin and the rest of the clan in that drug category.  A side note: The FDA banned fluorquinolones from poulty feed in 2005 but in 2012 they were still found in tested poultry. )

CYP1A2 is responsible for detoxifying “xenobiotics”, which are drugs, chemicals, and environmental toxins foreign to the human body. Drugs detoxified in this pathway include both pharmaceuticals drugs like birth control pills or antidepressants, and naturally-occurring ones like caffeine.

The goal of the liver cleanse in a detox diet is to lighten the load on the detoxification pathway to help the liver efficiently clear and release stored toxins.  (This can be a problem if people have a snp in the gene MTHFR.)

Some people have a genetic polymorphism in the CYP1A2 gene so its enzyme activity is likely impacted. (That’s me).

What is a Genetic Polymorphism or SNP (single nucleotide polymorphism)?

All of us have small differences in the information that our DNA contains, and it’s these differences that make each of us unique. Gene polymorphisms are slight changes in the genetic code that are present in at least one percent of the population or as much as 50% or more.

For example – one genetic “letter” (A, T, C, or G) may be replaced by another. These polymorphisms can lead to different processes in the body, just as altering one letter in a word can completely change its meaning, like MAP or MOP.  Those are very different meanings. When the change affects only one genetic letter, it is called a “single nucleotide polymorphism” (or SNP, pronounced “snip”).

What is SNP

Glyphosate and Cytochrome P450

CYP enzymes play crucial roles in biology, one of which is to detoxify xenobiotics. Thus, glyphosate enhances the damaging effects of other food borne chemical residues and environmental toxins. Negative impact on the body is insidious and manifests slowly over time as inflammation damages cellular systems throughout the body.

Interference with CYP enzymes acts synergistically with disruption of the biosynthesis of aromatic amino acids by gut bacteria, as well as impairment in serum sulfate transport. The consequences of this are most of the diseases and conditions associated with a Western diet, which include gastrointestinal disorders, obesity, diabetes, heart disease, depression, autism, infertility, cancer and Alzheimer’s disease. This study explains the documented effects of glyphosate and its ability to induce disease, and shows that glyphosate is the “textbook example” of exogenous semiotic entropy: the disruption of homeostasis by environmental toxins.

So when people say I can’t eat organic, it is too expensive, I say it costs more in human disease and healthcare to eat non-organic. It costs ordinary people money to miss work, it costs companies and tax payers in the U.S. billions.

So why the resistance to keeping everyone healthy?  I think I already answered that above.

The sad fact is just 10 corporations control almost every product on grocery store shelves. Organic food companies are being bought by companies like Coca-Cola and Hershey.

How many of your products are owned by these ten mega-corporations?

Several bills have been introduced in the 114th Congress that address labeling of GE foods including the Genetically Engineered Food Right-to-Know Act (H.R. 913, S. 511) and the Safe and Accurate Food Labeling Act of 2015 (H.R. 1599). Generally these bills would amend the FFDCA to impose specific labeling requirements disclosing information about GE techniques used in the production of a particular food product.

That’s the first step for us in the U.S.


Comparative effects of the Roundup and glyphosate on mitochondrial oxidative phosphorylation


Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases

Determination of Glyphosate residues in human urine samples from 18 European countries

Weed-Whacking Herbicide Proves Deadly to Human Cells

Widely used herbicide linked to Cancer

Bertz and Granneman (Clin Pharmacokinet 1997 32 210-58)

What is BT Toxin

Cytotoxicity on human cells of Cry1Ab and Cry1Ac Bt insecticidal toxins alone or with a glyphosate-based herbicide

Maternal and fetal exposure to pesticides associated to genetically modified foods in Eastern Townships of Quebec, Canada

Rat Liver and Kidney Damage Following Exposure to Roundup

Banishing Glyphosate

How Roundup Damages Your Mitochondria

First Commercialized GMO Raised was Toxic to Farm Animals

Side Effects of Pesticides

Cholesterol Deficiency?

Cholesterol Pathway


Statins are a class of medications that poison an enzyme, HMG-CoA Reductase. You can’t expect to poison a critical enzyme long term and expect to have a good result. By poisoning HMG-CoA Reductase, all of the substances downstream to HMG-CoA will also be reduced.

Coenzyme Q10 is a biocatalyst that facilitates the activities of enzymes.  It is necessary for maintaining optimal muscle function.  CoQ10 is essential for cellular energy production.  The heart muscle contains one of the largest amounts of CoQ10 in the body.  If statin-induced muscle pain and weakness progresses, it can lead to a potentially fatal condition called rhabdomyolysis.  Doctors will frequently check their patients on statin drugs for an elevated muscle enzyme called creatine kinase.  When CK levels elevate, it suggests a serious problem with the statin drugs.  To avoid these problems, CoQ10, 150-300 mg should be prescribed with every statin prescription.

Brain Fog and Dementia – Adequate cholesterol levels are necessary for proper brain function.  Much of the brain is composed of fats (the majority of which is cholesterol).  Over 50% of dry weight of the cerebral cortex is cholesterol.  The elderly are particularly sensitive to decreases in cholesterol levels.  Cholesterol is the repair item for both the brain and the body; when there is damage to body tissue, cholesterol is produced locally in large amounts to help heal the area.  Those with the lowest cholesterol levels (<150mg/dl) consistently exhibit more brain fog and dementia as compared to those with higher cholesterol levels.

Depression – When there is adrenal fatigue with a resultant suboptimal adrenal hormone production, an elevated cholesterol level is the normal and expected response. When the adrenal hormones become imbalanced, one of the key problems that can develop is depression. By lowering cholesterol, statins can not only cause depression, they also have a tendency to exacerbate a depressive condition.  (TLS ACTS can help with adrenal fatigue.)

Cholesterol is a precursor to Vitamin D production. You are likely to be vitamin D deficient if your cholesterol is lowered. Cholesterol is necessary for proper absorption and digestion of fats and minerals. Cholesterol is the “glue” that holds the entire lipid cell layers together.  Leaky cell membranes could result in chronic illness and cancer. Cholesterol is necessary for the myelin sheath that covers all of our nerve cells.  Cholesterol is necessary for the immune system to fight against infection.


Side Effects of Statins

The most common side effect of statins is muscle pain and weakness.  Doctors reporting from individual practices say it is reported by patients about 20% of the time despite published data saying 1 – 5%.  The depletion of CoQ10 would be a logical conclusion for muscle aches and weakness because it is a biocatalyst that facilitates the activities of enzymes; it is necessary for maintaining optimal muscle function and cellular energy production.

If statin induced muscle pain and weakness progresses, it can lead to a potentially fatal condition called rhabdomyolysis.  This is why doctors will frequently check their patients who are on statin drugs for an elevated muscle enzyme called creatine kinase (CK).

The heart is the body’s largest muscle and contains the largest concentration of CoQ10.

Last year (2014) it was discovered statins have a negative effect on stem cells properties and with long term use an increased risk of cataract formation.

Statin therapy and plasma coenzyme Q10 concentration

The Impact of Statins on Biological Characteristics of Stem Cells Provides a Novel 2 Explanation for Their Pleiotropic Beneficial and Adverse Clinical Effects Reza Izadpanah1,2*, Deborah J Schächtele1 *, Andreas B Pfnür1 , Dong Lin1 , Douglas P Slakey2 3 , Philip J Kadowitz3 , Eckhard U A


Lifestyle changes are an alternative to taking prescription medication.  Sometimes statins are necessary but genetics only has a 5% impact.  95% is epigenetics; in other words how your lifestyle choices and your environment interact with your genetics.  How toxic your environment is, including the food you consume which will have a very big impact on your Microbiome (your gut), if you have endocrine disruptors all over your home and workplace, if you take prescription drugs, illegal drugs or smoke.  Exercise can change the expression of some of your genes so it is important.

The polymorphisms discussed below are genes that have been clinically tested in double blind placebo studies where changes in lifestyle were shown to positively impact the expression of the gene.


ADRB2 Impairs the breaking down of neutral fat (Slower metabolism) and causes unnecessary storing away of energy in the body, advantageous in the time of famine, but is now associated with obesity adjusting to modern day lifestyle.  People with variations of this gene tend to gain weight from carbohydrates.  This is about 50% of the population.

ADRB3 (Adrenoreceptor Beta 3) Susceptibility to and development of T2DM. (Type 2 diabetes)

Impairs the breaking down of neutral fat (Slower metabolism)

Causes unnecessary storing away of energy in the body, advantageous in the time of famine, but is now associated with obesity adjusting to modern day lifestyle.

This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis.

APOA2 (Apolipoprotein A-II) Studies repeated in several ethnic groups showed that the genetic variation can affect BMI but only when saturated fat in the diet is high.

The CC variation with high saturated fat diets, BMI is reported to be significantly higher. CC homozygote individuals have a heightened sensitivity to saturated fat.

FABP2 (Fatty Acid Binding Protein 2) important effect on postprandial lipids in vivo, potentially influencing plasma levels of lipids and atherogenesis.

Uptake and transport of saturated and unsaturated fats. Increased carb sensitivity, lipids and cholesterol.

These proteins participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance.

FTO (alpha-ketoglutarate-dependent dioxygenase FTO) is a protein that is associated with fat mass and obesity in both adults and children. Its function has not been completely determined yet. It is an alpha-ketoglutarate-dependent deoxygenase enzyme that repairs alkylated DNA and RNA by oxidative demethylation. Activity appears to be affected by eating and fasting. The enzyme is particularly active in areas of the brain that are associated with eating behavior.

FTO plays a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.

PPARG Individuals with the Pro/Pro genotype are likely to be more sensitive to negative effects of fats and refined carbohydrates in the diet and to a sedentary lifestyle. It has also been reported that higher proportions of MUFA (mono- unsaturated fats) in the diet compared to saturated fats is linked to a lower BMI This gene helps form and store fat and people with this gene tend to be sensitive to both carbs and fat. Fortunately only about 15% of the population have this variation.

TCF7L2 Increased risk of Type II diabetes. Less weight loss in response to lifestyle intervention unless high fiber intake is present.


The genes below put you at higher risk for injury.

GDP is associated with higher tendinopathy risk.  

COLA1A and COL5A1 put you at higher risk for ligament ruptures, shoulder dislocations and an 80% higher risk for osteoporosis. They are also associated with vasodilation, blood pressure control, efficiency of muscular contraction and cell hydration.  Extra stretching and hydration are more important for people who have these genetic variants and their trainers and health professionals (like physical therapists) should be aware of them.

Walking and swimming are low injury risk exercises.  Anything that would add the likelihood of injury should take into consideration these genetics.

Certain genetic variants can determine the best kinds of exercise.  Most people have a combination of power and endurance genes.  Some people have variations that can have more significant impact if they are athletes or trying to lose weight.  Andrew Steele is an Olympian who has received two silver medals, missing the gold by only one second.  To achieve those silver medals he had exercised in a way that was best for his body based on his genetics.  However he did not know that.  To train for the gold his trainers had him change his routine to one that was not aligned with his genetics.  He came down with Epstein Barr, an autoimmune condition some think is related to over-training.  (Possibly it is related more to training in a way that does not support genetics and makes individuals more vulnerable to other variants.) He did not even qualify for his home country Olympics.  This is a dramatic story but an important one for professional athletes to consider.


A Mediterranean Diet seems to be a sensible diet for most people.  Some may have to have a low-carb diet. Eating organic is important as insecticides, herbicides, chemicals and GMO will impact the expression of your DNA.  Some may not have the enzymes to digest dairy and some may be at risk for Celiac Disease.  Eat a diet that is mostly plants with a few nuts and seeds, healthy fats like avocado and olive oil and meats/seafood.  If you eliminate meats/seafood there could be problems and expert guidance is recommended, including lifestyle genetics.

Dr. Stephanie Seneff believes that the buildup doctors find in arteries is “cholesterol trapped in the wrong place,” or cholesterol trapped in the plaque. The reason it’s trapped in the plaque is because the LDL is damaged from excess sugar in the blood. As a result of our highly processed, starchy, sugary diets, many Americans have excess blood sugar. Once the sugar has damaged the LDL it cannot go back to the liver where the cholesterol would be processed and recycled back into the body. The plaque then builds up in the arteries, where it “waits for the opportunity to become cholesterol sulfate, which all of the body’s systems need,” Seneff says. “The bottleneck is the sulfate. Cholesterol needs sulfate to be mobile. The damage then is a consequence of lack of cholesterol and lack of sulfate.”

This may be why a much larger study in The Journal of the American Medical Association found “no overall significant association between egg consumption and heart disease.” In fact, the study of 118,000 people found that those who ate five or six eggs per week had significantly lower mean serum cholesterol levels than those who ate one egg per week.

Cruciferous vegetables have Sulphur as well and are important for people who have genetic variants that support the liver like GSTM1 and GSTT1.

Sunny Side Up; In Defense of Eggs


Everyone MUST supplement.  Dr. Mark Hyman says it best, “Maybe if we eat only wild, fresh, organic, local, non-genetically modified food grown in virgin, mineral and nutrient-rich soil that has not been transported across vast distances and stored for months before being eaten……AND work and live outside, breathe only fresh unpolluted air, drink only pure clean water, sleep nine hours per night, move the body every day, are free from chronic stressors and exposure to environmental toxins, then perhaps we might not need supplements.”

We still burn coal for energy and the by-product of burning coal is methyl-mercury.  We breathe it, it goes into our soil when it rains and it impacts (especially) root vegetables.  It goes into our water systems and impacts everything in those systems that we consume.

We’ve polluted our air, water and soil with herbicides, pesticides, chemicals and pharmaceuticals.  For example a kind of plastic, BPA will cause an increase in blood pressure.  There is almost 300,000 tons of it in the ocean alone.  We use plastics for everything now.  We should stop using plastics and Teflon coated items for food preparation and storage.


Antioxidants, Citrus Fiber, Fish Oils, Astaxanthin, Activated B-Complex, CoQ10


The above photo shows the inside of a coronary artery which has had the endothelial lining damaged.  There is a medical device called endoPAT that can measure endothelial damage inside the artery.

A bad score can mean a 300% higher risk for an adverse cardiac event.  Two anti-oxidants, OPC-3 and ORAC have demonstrated they can lower a bad score in 90 days using the endoPAT before and after.

(Accelerated antioxidant bioavailability of OPC-3 bioflavonoids administered as isotonic solution.

Cesarone MR1, Grossi MGDi Renzo AErrichi SSchönlau FWilmer JLLange MBlumenfeld J.)





The photo above contains results from many clinical studies on a patented citrus fiber, Sytrinol.  It can be found in a product called Advanced Lipitrim.  Combined with Fish Oils and Activated-B-Complex it can provide tremendous cardiovascular support.




Fish oil has been shown to lower elevated triglyceride levels as well as prevent blood clots and slow plaque growth.  It helps prevent sudden cardiac death and can normalize heart arrhythmias. 1,200 to 3,000mg per day is recommended.

As previously mentioned the oceans are quite polluted.  Senator Whitehouse of Rhode Island gave a speech on the state of the oceans and said when a whale beaches on RI shores, it is considered toxic waste.

There are manufacturers who do a fantastic job of cleaning pollutants out of fish oils.  They only use small fish like anchovies and sardines from remote parts of the ocean and the oil is cleaned and tested several times.  Most fish oils contain many pollutants; these will be the inexpensive ones.

Fish Oils in clinical studies have been shown to have the best bioavailability if they have 3:1 EPA: DHA

Flax Seed oil is no substitute for EPA and DHA as some people may think.  It is not converted to EPA and DHA in amounts required by the human body.

The human eye structure requires EPA and DHA for eye health.  (Resveratrol has been shown to be protective of the corneal endothelia.)

Krill Oil has not been shown to have the same bioavailability of fish oils as of this date 12/25/2015.

Astaxanthin has also been shown to be great for cardiovascular benefits.  It is also a lipophilic supplement like fish oils.

The patented form, astareal, has quite a few clinical studies.



B-Vitamins have so many benefits. They play roles as co-enzymes in the metabolism of protein, fat and carbohydrates, they support a healthy rate of metabolism and healthy skin and muscles. They support immune and nervous system functions and a healthy heart system.  They promote normal cell growth and division, energy and healthy mental outlook, mood and memory.

Some genetic mutations like MTHFR which is prevalent in more than 50% of the population require active ingredients.  Most B-Vitamins don’t have active ingredients.  B-Vitamins are almost always depleted by most prescription medications.

Anyone taking prescription medications and anyone who has eliminated meat would benefit from an active B-Complex.





Finally, sometimes statins are recommended; just a reminder that CoQ10 has to be taken alongside any statin.

Advanced CoQ10 contains the highest quality CoQ10 on the market called OptiPure®; natural vitamin E in its mixed tocopherol form; a unique blend of natural mixed carotenoids, and rice bran oil, providing gamma oryzanol and d-limonene.

CoQ10 is lipophilic which means the body likes to have it delivered in an oil based form, much like Omega IIIs and astaxanthin.

One rule with supplements: you get what you pay for.  Companies that spend millions to get patents that investigate the manufacturers they use, that develop products based on clinical science will cost more.

Bioavailability is critical.  If they don’t get where the body needs them in the amounts that it needs them, money is wasted and the environment is polluted.  Sometimes there will be tradeoffs that have to be made.

Bioavailability and Patents are important determinations. Discuss those with experts.

Information and clinical studies from DRUGS THAT DON’T WORK AND NATURAL THERAPIES THAT DO  by Dr. David Brownstein has been used in this document along with the clinical studies quoted.

Happy Holidays 2015


You are goodness and mercy and compassion and understanding.

You are peace and joy and light,

You are forgiveness and patience, strength and courage,

A helper in time of need, a comforter in time of sorrow,

A healer in time of injury

And a teacher in times of confusion

You are the deepest wisdom and the highest truth,

The greatest trust and the grandest love

You are these things and at moments in your life you have known

Yourself as these things

Choose now to know yourself as these things always



Fluoroquinolones and What Might Help

Six years ago I dated a man who worked for a pharmaceutical company.  I only went on two dates with him but I remember he was a runner and he was complaining about digestive problems that he had been having for three years after taking one of his company’s antibiotics, Levaquin.  He said while he was taking it he was out running and could feel something strange happening to his heals.

He stopped running and called a nurse at his company and asked her to look up side effects.  She told him, “Stop running right now. One of the side effects is spontaneous rupture of the Achilles Tendon.”

I warned PTs that I work with and they all responded that they’d already treated multiple patients with the Achilles tendon issue related to the antibiotic.

Three years ago I was hospitalized with an infection.  The night I went to the emergency room I had a white cell count in the fatal area.  The reason all patients need an advocate when they are in the hospital is that the patient can’t be expected to advocate for themselves when they are literally “dying.”

Cipro and Levaquin saved my life.  However, I have MTHFR (and other genetic polymorphisms that are listed in pharmacogenetics screenings as contraindicated with some pharmaceuticals). I have had infections a number of times (a symptom of MTHFR) and was treated with antibiotics that did not have the serious side effects of fluoroquinolones.

I was treated with FQs in March, 2013.  The first side effect I noticed was blurry eyes.  I was 64 and had not needed glasses previously.  When I saw an eye doctor she told me that the cocktail of fluoroquinolones I was given causes eye damage.  Blurry vision and trouble switching from close up to distance is what I’ve noticed.  Studies in Pubmed indicate fluoroquinolones inhibit corneal cell growth and repair.  (Ironically, they are in eye drops.)

I may have also received them after my daughter’s birth when I became septic in 1988.  Shortly after that I started having tendon problems in my wrists, shoulder and ankle.  I didn’t connect those to my treatment.

Some people are saying they experience a cycle of pain.  I’ve noticed 3-4 months I have pain for up to 3 days, then it mostly stops except for the gluteal tendon which has been constant.  I’ve literally had a pain in the ass for years. (I’m 67 years old.) People who experience the cycles of pain are calling it floxing.

Some people say they are in pain all the time.  There is a documentary about fluoroquinolones here.

Icing affected tendons helps me. I’ve noticed tendons and ligaments that experience repetitive use or have been damaged previously might be affected more by side effects. Hormones like Cortisol and lack of sleep might increase side effects.

Microcore ice packs have helped me.

I put them in a pad called Better Back to sit on to numb the discomfort from gluteal tendinopathy.  I use a bandage to wrap them around my wrists and ankles.

There is a support group on FB and

There is a note by an MD to give your MD at the bottom of this blog along with the links I have found inside PubMed.  (Double Blind, Clinical studies on fluoroquinolones.)

What might help?

 Avoid all fluoroquinolones in the future. Be tested for genetic contraindications.

Polytrim can be substituted for antibacterial eye drops.        

BluTek lenses in glasses to deflect further damage to eyes from digital blue light.

My eye doctor told me my eyesight would not improve.  However my eyes did improve with patented lutein, zeaxanthin, astaxanthin, pycnogenol, resveratrol and other antioxidants including OPCs and Omega III fish oils. If I stop taking the protocol, they worsen.  I have since found clinical studies in PubMed indicating resveratrol protects the endothelial cells of the cornea.  I had been taking resveratrol for over a decade so it may have had some protective effect.

When working with health professionals ask if they know about MTHFR, genetic lifestyle screenings

and pharmacogenetics screenings.  Find the ones who know.

Eat a lot of green leafy vegetables (organic if possible).  Fluoroquinolones cause mitochondrial damage.  Dr. Terry Wahls did a TED Talk called Mind Your Mitochondria.   She talks about how she cured herself from MS, a disease that impacts mitochondria.


 For years I’ve heard health professionals and experts say food alone is all that is necessary for health.  That might have been true decades ago but it is not true now.

Industrialized farming and food practices in the US as of 2015 leave soils severely depleted of minerals – more than 85%.

Food is harvested much too soon for full maturation of the plant therefore it will be lacking in nutrients and enzymes.  Have you noticed fruits or vegetables that are hard as rocks in the grocery store?

You can watch a presentation I did for doctors on the topic here, GMO, glyphosate and surfactants, BT toxin.

You would have to eat an excess of 12 servings of organic vegetables per day to get the minimum nutrients if you have no health issues.

The MDs and other health professionals I work with who pay attention to environment and epigenetics say the environment is much more toxic now.

They say it is nearly impossible to get the nutrients you need from food in the US if you have no health conditions.

Fluoroquinolones deplete iron (and other minerals as well as magnesium, calcium and antioxidants).  Iron is already depleted in food.  The two diagrams below only go to the late 1990s.







Humans can’t make some essential nutrients.  If you can’t make them and you can’t get them from your food, and they are depleted by prescriptions, you need to supplement.  Nutrients need co-factors and enzymes and other nutrients.  Working with an expert who knows about this and ingredients that are patented and bioavailable will help.

Depending on severity of symptoms, digestive issues, etc. IV or Isotonic  antioxidants including OPCs (cross the blood brain barrier) and Glutathione, magnesium, calcium, iron, vitamin D, activated B-Complex with 5-MTHF (Quadrafolic), amino acids for collagen synthesis and repair of tendons can be put into a custom cocktail.

I bolded nutrients mentioned in clinical studies as being depleted.

Bromelain is the enemy of protein and cytokines are proteins that may be created in excess related to inflammation.  Genetic Polymorphisms like TNF and IL6 may put that person at risk for over-inflammation.

I have found digestive enzymes, probiotics and pharmaceutical grade aloe juice might heal the gut and address the depletion of good bacteria.

(Commercial brands of aloe that are carried in stores like Whole Foods are mostly water and are not pharmaceutical grade. A good aloe should say 150% concentrated aloe, should have the more toxic part of the plants removed and should have the Aloe Association Seal.)

*AVOID ALL SYNTHETIC FOLIC ACID if you have MTHFR polymorphism.

Why Intermittent Fasting May Help Pain and Fatigue

Learn more about Intermittent Fasting here.

Some of you may balk at the idea of calorie restriction when dealing with chronic fatigue, but there’s actually compelling evidence showing it can play a significant role in correcting mitochondrial function. As noted earlier, when excessive electrons are produced in the mitochondria they create highly destructive free radicals. The best way to address this is to limit excessive electron production, as if there are fewer free electrons, they’re less likely to leak out.

So how do you limit free electrons?

One of the most effective ways to do this is through calorie restriction, which in fact is a proven method to increase lifespan in mammals. Resveratrol has also been shown to activate the SIRT1 gene which is the genetic mechanism that caloric restriction is activating.

The drawback of calorie restriction is that it is enormously difficult to maintain over extended periods of time. Fortunately, research has shown that intermittent fasting effectively mimics calorie restriction, and it’s far easier to comply with, especially if you do it daily, restricting your eating to a window of about six to eight hours, where your last meal is taken at least three hours before bedtime. Ideally, aim for as much as six hours between your last meal and your scheduled bedtime.

Note on Environment

 The U.S. is still addicted to fossil fuels.  The by-product of burning coal is methyl-mercury. It is in the air, water and ground.

Senator Whitehouse of R.I. said a whale that beaches on R.I. shores is considered toxic waste.  The cod industry in New England has collapsed.  The oyster industry in Mid-Atlantic has collapsed.

Pesticides are spread like water. Bees are dying.  No bees, no food.

This topic is another book but it impacts quality of food, air and water.

 *Synthetic folic acid UMFA (unmetabolized folic acid) is being associated with MTHFR polymorphism.  People with MTHFR, 50%+ of the population should avoid UMFA.  Linked to interfering with T cells (vulnerability to cancer) and neurological problems.  The only folate that does not mask a B-12 deficiency is 5-MTHF. (Quadrafolic) Synthetic folic acid is in most fortified foods as of 11/8/2015 in the U.S.

When looking at nutraceuticals, patented, science based protocols are advised.  The manufacturer has spent millions to prove the effectiveness of their product.  Many companies use the patented clinical studies but they do not have the patented ingredient.

Problems related to fluoroquinolones were reported as early as 1980s from Europe.

The Freedom of Information Act has obtained data showing more than 50,000 reported adverse reactions and 3,000 deaths.  We know that most doctors don’t report the side effects and because of the “constellation of symptoms” most patients don’t connect the dots so the figure for adverse side effects could be in the millions.

Examples of well known fluoroquinolones are Avelox, Cipro (Bayer), and Levaquin (Johnson and Johnson).  These are not the only ones.  You have to ask.

Letter for an MD by an MD:

Dear Doctor,

As you are probably aware, the fluoroquinolone class of antibiotics is useful for certain serious infections. Unfortunately, fluoroquinolones also have a long history of serious adverse drug reactions, many of them long term . (1) As a consequence of these reactions, several of these drugs have been removed from clinical practice or their use severely restricted. Besides the severe life threatening immediate reactions, those of a more chronic nature may occur.

The spectrum of these adverse reactions is extremely broad. Patients suffering from these reactions are often misdiagnosed, referred for a psychiatric consult or even unfairly labeled as “difficult patients.”

Many physicians have not been properly educated about the severe nature of these chronic adverse reactions, some of which result in life-long disabilities. Post-marketing studies of several flouroquinolones have shown an incidence of adverse reactions much higher than were originally reported in pre-clinical studies. (1,2,3)

You are probably aware that the fluoroquinolones are eukaryotic DNA gyrase and topoisomerase inhibitors very similar to many antineoplastic agents. Because of their similar mechanisms of action, it’s no surprise that fluoroquinolones and many antineoplastic agents share similar toxicity profiles. Studies have even been conducted using fluoroquinolones to inhibit neoplastic chondrocyte growth in chondrosarcoma. (4)

There are many patients who have a syndrome of associated symptoms that include, but are not limited to: CNS agitation, depression, insomnia, new-onset anxiety and panic attacks, and even elevated intracranial pressure and visual abnormalities. They may also present with peripheral neuropathy usually of the small fiber type with temperature and pain sensory aberrations, but also often involving larger sensory and motor nerves. Spontaneous muscle activity with fasciculations, myokymia and myoclonic jerks may also occur. Many have musculoskeletal damage with degeneration of cartilage and tendons often leading to tendon rupture and severe ongoing musculoskeletal pain long after therapy has been discontinued. (1,2,3,4,5,6,7,8)

This complex symptomatology does not usually resolve after discontinuation of the inducing fluoroquinolone and may in fact worsen. Many patients go on to have disability that may persist for years. (1) Unfortunately, such patients are often seen by many physicians from multiple specialties who, given the complex symptomatology, fail to recognize a unifying diagnosis.

The mechanism of injury is not fully apparent, but several studies have been conducted and researchers have implicated the following possible mechanisms:

  1. Inhibition or disruption of the CNS GABA receptor. (9)
  2. Depletion of magnesium and disruption of cellular enzymatic function. (10)
  3. Disruption of mitochondrial function and energy production. (11,12)
  4. Oxidative injury and cellular death. (14)

This seems to be a functional disorder and structural abnormalities are not usually seen on radiological studies. (13) Patients may have abnormal EMG/NCV studies, abnormal skin punch neurologic density and morphology, abnormal vasomotor and sudomotor function on autonomic testing, and abnormal degeneration of tendons and cartilage on MRI. (13)

There may be a large number of these patients with coexisting endocrine abnormalities including: antithyroid antibodies and abnormal thyroid function, abnormal adrenal function with either hyper or hypocortisolism, hypogonadism, hypo or hyperglycemia and possibly impaired pituitary function. (13)

Most patients suffering from these side effects have a very clear onset of symptoms temporally related to a course of fluoroquinolone antibiotic. (13) They were often given the fluoroquinolone in conjunction with a corticosteroid or NSAID. Both of these classes of medications are associated with an increased incidence of adverse drug reaction from fluoroquinolones. (10,13)

As of yet no scientifically proven effective treatment is known, however patients will definitely benefit from your caring support and appropriate informed care. Of course, other diseases with similar symptoms need to be carefully ruled out.

There exists a large community of these patients who share information on the World Wide Web. Their numbers grow as the prescription of fluoroquinolones increases. Many of these patients are professionals like myself who have been affected by these drugs. Thank you for your time and consideration.

Todd R. Plumb MD


  1. Cohen JS; Peripheral Neuropathy Associated With Fluoroquinolones
    Annals of Pharmacotherapy. 2001;35(12):1540-1547
  2. Francesca Lunzer Kritz; New Cipro, Same Side Effects, Washington Post, December 24, 2002.
  3. Shepard CW et al; Antimicrobial Postexposure Prophylaxis for Anthrax: Adverse Events and Adherence Emerging Infectious Diseases ¡E Vol. 8, No. 10, October 2002
  4. Fox EJ et al; The effects of ciprofloxacin and paclitaxel on metastatic and recurrent chondrosarcoma COMMUNITY ONCOLOGY ¡½ November/December 2005
  5. Physisicans Desk Referfence 2006
  6. de Bazignan DA etal; Psychiatric adverse effects of fluoroquinolone: review of cases from the French pharmacologic surveillance database[Article in French] Rev Med Interne. 2006 Jun;27(6):448-52. Epub 2006 Mar 9
  7. FDA Medical Bulletin * October 1996 * Volume 26 Number 3
  8. Saint F. etal; Tendinopathy associated with fluoroquinolones: individuals at risk, incriminated physiopathologic mechanisms, therapeutic management [Article in French]
    Prog Urol. 2001 Dec;11(6):1331-4.

  9. De Sano A. etal; Adverse Reactions to Fluoroquinolones. An Overview on Mechanistic Aspects Current Medicinal Chemistry 2001, 8, 371-384 371
  10. Stahlmann R. etal; Effects of magnesium deficiency on joint cartilage in immature Beagle dogsimmunohistochemistry, electron microscopy, and mineral concentrations, Archives of Toxicology. Jan. 2000 73(11,12)
  11. Hayem G. Cytofluorometric analysis of chondrotoxicity of fluoroquinolone antimicrobial agents. Antimicrob Agents Chemother. 1994 Feb;38(2):243- 7.
  12. Kozie[lstrok]; Ciprofloxacin reduces mitochondrial potential and inhibits calcium entry into Jurkat cells
    R European Journal of Biochemistry 2003; 1 Supplement 1 July: Abstract number: P4.8-33., Zab[lstrok]ocki K., Szczepanowska
  14. Simonin MA etal. Pefloxacin-Induced Achilles Tendon Toxicity in Rodents: Biochemical Changes in Proteoglycan Synthesis and Oxidative Damage to CollagenAntimicrobial Agents and Chemotherapy, April 2000, p. 867-872, Vol. 44, No. 4

Note to readers: The purpose of this E-Letter is solely informational and educational. The information herein should not be considered to be a substitute for the direct medical advice of your doctor, nor is it meant to encourage the diagnosis or treatment of any illness, disease, or other medical problem by laypersons. If you are under a physician’s care for any condition, he or she can advise you whether the information in this E-Letter is suitable for you. Readers should not make any changes in drugs, doses, or any other aspects of their medical treatment unless specifically directed to do so by their own doctors.

There are more updated links like the ones below here.

FDA November 4th, 2015

Suzy Cohen


Musculoskeletal problems

​​Mitochondrial Dysfunction

Increased Oxidative Stress

NY Times


DNA Adduction

2015  Fluoroquinolones, serious side effects

2015  Fluoroquinolones in drinking water

2015  Fluoroquinolones ubiquitous surface waters, waste waters

2015  FQs Ecotoxilogical effects aquatic organisms

2015  Fluoroquinolones and Corneal Fibroblast Motility

2015  Cipro and gluteal tendinopathy

2015  FQs and Neurological Toxicity

2015  FQs Increased Oxidative Stress

Kathy O’Donnell Kaufman put some documents together and continues to update.

 Some of the links are from The FDA has not evaluated any of the information I put together. I, alone, am solely responsible for it.  Kathy.od (skype)  It is as science based as I can make it with the assistance of scientists and health professionals.

I am in the U.S. where the environment is worse therefore more toxic and epigenetics are affected. Many MDs I know agree the most dangerous thing in America is an empty hospital bed.

How We Can Halt the Cipro_Levaquin Catastrophe