Fluoroquinolones and What Might Help

Six years ago I dated a man who worked for a pharmaceutical company.  I only went on two dates with him but I remember he was a runner and he was complaining about digestive problems that he had been having for three years after taking one of his company’s antibiotics, Levaquin.  He said while he was taking it he was out running and could feel something strange happening to his heals.

He stopped running and called a nurse at his company and asked her to look up side effects.  She told him, “Stop running right now. One of the side effects is spontaneous rupture of the Achilles Tendon.”

I warned PTs that I work with and they all responded that they’d already treated multiple patients with the Achilles tendon issue related to the antibiotic.

Three years ago I was hospitalized with an infection.  The night I went to the emergency room I had a white cell count in the fatal area.  The reason all patients need an advocate when they are in the hospital is that the patient can’t be expected to advocate for themselves when they are literally “dying.”

Cipro and Levaquin saved my life.  However, I have MTHFR (and other genetic polymorphisms that are listed in pharmacogenetics screenings as contraindicated with some pharmaceuticals). I have had infections a number of times (a symptom of MTHFR) and was treated with antibiotics that did not have the serious side effects of fluoroquinolones.

I was treated with FQs in March, 2013.  The first side effect I noticed was blurry eyes.  I was 64 and had not needed glasses previously.  When I saw an eye doctor she told me that the cocktail of fluoroquinolones I was given causes eye damage.  Blurry vision and trouble switching from close up to distance is what I’ve noticed.  Studies in Pubmed indicate fluoroquinolones inhibit corneal cell growth and repair.  (Ironically, they are in eye drops.)

I may have also received them after my daughter’s birth when I became septic in 1988.  Shortly after that I started having tendon problems in my wrists, shoulder and ankle.  I didn’t connect those to my treatment.

Some people are saying they experience a cycle of pain.  I’ve noticed 3-4 months I have pain for up to 3 days, then it mostly stops except for the gluteal tendon which has been constant.  I’ve literally had a pain in the ass for years. (I’m 67 years old.) People who experience the cycles of pain are calling it floxing.

Some people say they are in pain all the time.  There is a documentary about fluoroquinolones here.

Icing affected tendons helps me. I’ve noticed tendons and ligaments that experience repetitive use or have been damaged previously might be affected more by side effects. Hormones like Cortisol and lack of sleep might increase side effects.

Microcore ice packs have helped me.

I put them in a pad called Better Back to sit on to numb the discomfort from gluteal tendinopathy.  I use a bandage to wrap them around my wrists and ankles.

There is a support group on FB and www.floxiehope.com

There is a note by an MD to give your MD at the bottom of this blog along with the links I have found inside PubMed.  (Double Blind, Clinical studies on fluoroquinolones.)

What might help?

 Avoid all fluoroquinolones in the future. Be tested for genetic contraindications.

Polytrim can be substituted for antibacterial eye drops.        

BluTek lenses in glasses to deflect further damage to eyes from digital blue light.

My eye doctor told me my eyesight would not improve.  However my eyes did improve with patented lutein, zeaxanthin, astaxanthin, pycnogenol, resveratrol and other antioxidants including OPCs and Omega III fish oils. If I stop taking the protocol, they worsen.  I have since found clinical studies in PubMed indicating resveratrol protects the endothelial cells of the cornea.  I had been taking resveratrol for over a decade so it may have had some protective effect.

When working with health professionals ask if they know about MTHFR, genetic lifestyle screenings

and pharmacogenetics screenings.  Find the ones who know.

Eat a lot of green leafy vegetables (organic if possible).  Fluoroquinolones cause mitochondrial damage.  Dr. Terry Wahls did a TED Talk called Mind Your Mitochondria.   She talks about how she cured herself from MS, a disease that impacts mitochondria.


 For years I’ve heard health professionals and experts say food alone is all that is necessary for health.  That might have been true decades ago but it is not true now.

Industrialized farming and food practices in the US as of 2015 leave soils severely depleted of minerals – more than 85%.

Food is harvested much too soon for full maturation of the plant therefore it will be lacking in nutrients and enzymes.  Have you noticed fruits or vegetables that are hard as rocks in the grocery store?

You can watch a presentation I did for doctors on the topic here, GMO, glyphosate and surfactants, BT toxin.

You would have to eat an excess of 12 servings of organic vegetables per day to get the minimum nutrients if you have no health issues.

The MDs and other health professionals I work with who pay attention to environment and epigenetics say the environment is much more toxic now.

They say it is nearly impossible to get the nutrients you need from food in the US if you have no health conditions.

Fluoroquinolones deplete iron (and other minerals as well as magnesium, calcium and antioxidants).  Iron is already depleted in food.  The two diagrams below only go to the late 1990s.







Humans can’t make some essential nutrients.  If you can’t make them and you can’t get them from your food, and they are depleted by prescriptions, you need to supplement.  Nutrients need co-factors and enzymes and other nutrients.  Working with an expert who knows about this and ingredients that are patented and bioavailable will help.

Depending on severity of symptoms, digestive issues, etc. IV or Isotonic  antioxidants including OPCs (cross the blood brain barrier) and Glutathione, magnesium, calcium, iron, vitamin D, activated B-Complex with 5-MTHF (Quadrafolic), amino acids for collagen synthesis and repair of tendons can be put into a custom cocktail.

I bolded nutrients mentioned in clinical studies as being depleted.

Bromelain is the enemy of protein and cytokines are proteins that may be created in excess related to inflammation.  Genetic Polymorphisms like TNF and IL6 may put that person at risk for over-inflammation.

I have found digestive enzymes, probiotics and pharmaceutical grade aloe juice might heal the gut and address the depletion of good bacteria.

(Commercial brands of aloe that are carried in stores like Whole Foods are mostly water and are not pharmaceutical grade. A good aloe should say 150% concentrated aloe, should have the more toxic part of the plants removed and should have the Aloe Association Seal.)

*AVOID ALL SYNTHETIC FOLIC ACID if you have MTHFR polymorphism.

Why Intermittent Fasting May Help Pain and Fatigue

Some of you may balk at the idea of calorie restriction when dealing with chronic fatigue, but there’s actually compelling evidence showing it can play a significant role in correcting mitochondrial function. As noted earlier, when excessive electrons are produced in the mitochondria they create highly destructive free radicals. The best way to address this is to limit excessive electron production, as if there are fewer free electrons, they’re less likely to leak out.

So how do you limit free electrons?

One of the most effective ways to do this is through calorie restriction, which in fact is a proven method to increase lifespan in mammals. Resveratrol has also been shown to activate the SIRT1 gene which is the genetic mechanism that caloric restriction is activating.

The drawback of calorie restriction is that it is enormously difficult to maintain over extended periods of time. Fortunately, research has shown that intermittent fasting effectively mimics calorie restriction, and it’s far easier to comply with, especially if you do it daily, restricting your eating to a window of about six to eight hours, where your last meal is taken at least three hours before bedtime. Ideally, aim for as much as six hours between your last meal and your scheduled bedtime.

Note on Environment

 The U.S. is still addicted to fossil fuels.  The by-product of burning coal is methyl-mercury. It is in the air, water and ground.

Senator Whitehouse of R.I. said a whale that beaches on R.I. shores is considered toxic waste.  The cod industry in New England has collapsed.  The oyster industry in Mid-Atlantic has collapsed.

Pesticides are spread like water. Bees are dying.  No bees, no food.

This topic is another book but it impacts quality of food, air and water.

 *Synthetic folic acid UMFA (unmetabolized folic acid) is being associated with MTHFR polymorphism.  People with MTHFR, 50%+ of the population should avoid UMFA.  Linked to interfering with T cells (vulnerability to cancer) and neurological problems.  The only folate that does not mask a B-12 deficiency is 5-MTHF. (Quadrafolic) Synthetic folic acid is in most fortified foods as of 11/8/2015 in the U.S.

When looking at nutraceuticals, patented, science based protocols are advised.  The manufacturer has spent millions to prove the effectiveness of their product.  Many companies use the patented clinical studies but they do not have the patented ingredient.

Problems related to fluoroquinolones were reported as early as 1980s from Europe.

The Freedom of Information Act has obtained data showing more than 50,000 reported adverse reactions and 3,000 deaths.  We know that most doctors don’t report the side effects and because of the “constellation of symptoms” most patients don’t connect the dots so the figure for adverse side effects could be in the millions.

Examples of well known fluoroquinolones are Avelox, Cipro (Bayer), and Levaquin (Johnson and Johnson).  These are not the only ones.  You have to ask.

Letter for an MD by an MD:

Dear Doctor,

As you are probably aware, the fluoroquinolone class of antibiotics is useful for certain serious infections. Unfortunately, fluoroquinolones also have a long history of serious adverse drug reactions, many of them long term . (1) As a consequence of these reactions, several of these drugs have been removed from clinical practice or their use severely restricted. Besides the severe life threatening immediate reactions, those of a more chronic nature may occur.

The spectrum of these adverse reactions is extremely broad. Patients suffering from these reactions are often misdiagnosed, referred for a psychiatric consult or even unfairly labeled as “difficult patients.”

Many physicians have not been properly educated about the severe nature of these chronic adverse reactions, some of which result in life-long disabilities. Post-marketing studies of several flouroquinolones have shown an incidence of adverse reactions much higher than were originally reported in pre-clinical studies. (1,2,3)

You are probably aware that the fluoroquinolones are eukaryotic DNA gyrase and topoisomerase inhibitors very similar to many antineoplastic agents. Because of their similar mechanisms of action, it’s no surprise that fluoroquinolones and many antineoplastic agents share similar toxicity profiles. Studies have even been conducted using fluoroquinolones to inhibit neoplastic chondrocyte growth in chondrosarcoma. (4)

There are many patients who have a syndrome of associated symptoms that include, but are not limited to: CNS agitation, depression, insomnia, new-onset anxiety and panic attacks, and even elevated intracranial pressure and visual abnormalities. They may also present with peripheral neuropathy usually of the small fiber type with temperature and pain sensory aberrations, but also often involving larger sensory and motor nerves. Spontaneous muscle activity with fasciculations, myokymia and myoclonic jerks may also occur. Many have musculoskeletal damage with degeneration of cartilage and tendons often leading to tendon rupture and severe ongoing musculoskeletal pain long after therapy has been discontinued. (1,2,3,4,5,6,7,8)

This complex symptomatology does not usually resolve after discontinuation of the inducing fluoroquinolone and may in fact worsen. Many patients go on to have disability that may persist for years. (1) Unfortunately, such patients are often seen by many physicians from multiple specialties who, given the complex symptomatology, fail to recognize a unifying diagnosis.

The mechanism of injury is not fully apparent, but several studies have been conducted and researchers have implicated the following possible mechanisms:

  1. Inhibition or disruption of the CNS GABA receptor. (9)
  2. Depletion of magnesium and disruption of cellular enzymatic function. (10)
  3. Disruption of mitochondrial function and energy production. (11,12)
  4. Oxidative injury and cellular death. (14)

This seems to be a functional disorder and structural abnormalities are not usually seen on radiological studies. (13) Patients may have abnormal EMG/NCV studies, abnormal skin punch neurologic density and morphology, abnormal vasomotor and sudomotor function on autonomic testing, and abnormal degeneration of tendons and cartilage on MRI. (13)

There may be a large number of these patients with coexisting endocrine abnormalities including: antithyroid antibodies and abnormal thyroid function, abnormal adrenal function with either hyper or hypocortisolism, hypogonadism, hypo or hyperglycemia and possibly impaired pituitary function. (13)

Most patients suffering from these side effects have a very clear onset of symptoms temporally related to a course of fluoroquinolone antibiotic. (13) They were often given the fluoroquinolone in conjunction with a corticosteroid or NSAID. Both of these classes of medications are associated with an increased incidence of adverse drug reaction from fluoroquinolones. (10,13)

As of yet no scientifically proven effective treatment is known, however patients will definitely benefit from your caring support and appropriate informed care. Of course, other diseases with similar symptoms need to be carefully ruled out.

There exists a large community of these patients who share information on the World Wide Web. Their numbers grow as the prescription of fluoroquinolones increases. Many of these patients are professionals like myself who have been affected by these drugs. Thank you for your time and consideration.

Todd R. Plumb MD


  1. Cohen JS; Peripheral Neuropathy Associated With Fluoroquinolones
    Annals of Pharmacotherapy. 2001;35(12):1540-1547
  2. Francesca Lunzer Kritz; New Cipro, Same Side Effects, Washington Post, December 24, 2002.
  3. Shepard CW et al; Antimicrobial Postexposure Prophylaxis for Anthrax: Adverse Events and Adherence Emerging Infectious Diseases ¡E Vol. 8, No. 10, October 2002
  4. Fox EJ et al; The effects of ciprofloxacin and paclitaxel on metastatic and recurrent chondrosarcoma COMMUNITY ONCOLOGY ¡½ November/December 2005
  5. Physisicans Desk Referfence 2006
  6. de Bazignan DA etal; Psychiatric adverse effects of fluoroquinolone: review of cases from the French pharmacologic surveillance database[Article in French] Rev Med Interne. 2006 Jun;27(6):448-52. Epub 2006 Mar 9
  7. FDA Medical Bulletin * October 1996 * Volume 26 Number 3
  8. Saint F. etal; Tendinopathy associated with fluoroquinolones: individuals at risk, incriminated physiopathologic mechanisms, therapeutic management [Article in French]
    Prog Urol. 2001 Dec;11(6):1331-4.

  9. De Sano A. etal; Adverse Reactions to Fluoroquinolones. An Overview on Mechanistic Aspects Current Medicinal Chemistry 2001, 8, 371-384 371
  10. Stahlmann R. etal; Effects of magnesium deficiency on joint cartilage in immature Beagle dogsimmunohistochemistry, electron microscopy, and mineral concentrations, Archives of Toxicology. Jan. 2000 73(11,12)
  11. Hayem G. Cytofluorometric analysis of chondrotoxicity of fluoroquinolone antimicrobial agents. Antimicrob Agents Chemother. 1994 Feb;38(2):243- 7.
  12. Kozie[lstrok]; Ciprofloxacin reduces mitochondrial potential and inhibits calcium entry into Jurkat cells
    R European Journal of Biochemistry 2003; 1 Supplement 1 July: Abstract number: P4.8-33., Zab[lstrok]ocki K., Szczepanowska
  13. http://health.groups.yahoo.com/group/quinolones/
  14. Simonin MA etal. Pefloxacin-Induced Achilles Tendon Toxicity in Rodents: Biochemical Changes in Proteoglycan Synthesis and Oxidative Damage to CollagenAntimicrobial Agents and Chemotherapy, April 2000, p. 867-872, Vol. 44, No. 4

Note to readers: The purpose of this E-Letter is solely informational and educational. The information herein should not be considered to be a substitute for the direct medical advice of your doctor, nor is it meant to encourage the diagnosis or treatment of any illness, disease, or other medical problem by laypersons. If you are under a physician’s care for any condition, he or she can advise you whether the information in this E-Letter is suitable for you. Readers should not make any changes in drugs, doses, or any other aspects of their medical treatment unless specifically directed to do so by their own doctors.

There are more updated links like the ones below here.

FDA November 4th, 2015

Suzy Cohen


Musculoskeletal problems

​​Mitochondrial Dysfunction

Increased Oxidative Stress

NY Times


DNA Adduction

2015  Fluoroquinolones, serious side effects

2015  Fluoroquinolones in drinking water

2015  Fluoroquinolones ubiquitous surface waters, waste waters

2015  FQs Ecotoxilogical effects aquatic organisms

2015  Fluoroquinolones and Corneal Fibroblast Motility

2015  Cipro and gluteal tendinopathy

2015  FQs and Neurological Toxicity

2015  FQs Increased Oxidative Stress

Kathy O’Donnell Kaufman put some documents together and continues to update.

 Some of the links are from www.pubmed.com. The FDA has not evaluated any of the information I put together. I, alone, am solely responsible for it.  Kathy.od (skype) kathy@criticalhealth.org.  It is as science based as I can make it with the assistance of scientists and health professionals.

I am in the U.S. where the environment is worse therefore more toxic and epigenetics are affected. Many MDs I know agree the most dangerous thing in America is an empty hospital bed.

How We Can Halt the Cipro_Levaquin Catastrophe


Digestive Disorders, Genetics and Epigenetics



Digestive Disorders….

Crohn’s disease has an energetic, or vibrational, underlying cause conditioned by mental and emotional patterns of thoughts and feeling-reactions that maintain an underlying condition of stress in the physical body. These underlying stress-producing energetic patterns keep the body in a fight or flight response mode.

Any treatment to bring about a “cure” of Crohn’s disease must necessarily include addressing this underlying energetic cause. Without this factor properly addressed and cleared, all treatments, medical and/or alternative, will only bring about relief and management of the condition.
Crohn’s disease is usually preceded by chronic indigestion. The cause of Crohn’s disease, diverticulitis, colitis and irritable bowel syndrome (IBS) is probably chronic indigestion.

Here is the definition of Crohn’s disease taken from the Mayo Clinic
“Crohn’s disease is a chronic inflammatory disease of the intestines. It primarily causes ulcerations (breaks in the lining) of the small intestines, but can affect the digestive system anywhere from the mouth to the anus. It is named after the physician who described the disease in 1932. It also is called granulomatous enteritis or colitis, regional enteritis, ileitis, or terminal ileitis.”

(Note: The Ileum is another name for the last section of the small intestines, the part that connects to the large intestines (or ascending colon), which is where the appendix is also located.)

To answer the question “What causes Crohn’s disease?” one must first answer the question “What causes inflammation in the intestines?” Right? So, let’s think this through by following the digestive process. But first let’s look at the inflammatory process.

The Cause of Inflammation
What causes inflammation is the immune system. It’s the body’s way of dealing with infection. Infection is the immune system’s way of dealing with foreign matter that is not being eliminated. Food is foreign matter to the body. It is supposed to be digested and then eliminated from the intestinal tract.  There are also genetic polymorphisms like TNF, IL6 and CRP that contribute to excessive inflammation. (While still controversial, studies of depression and IBD are currently being linked to TNF levels.)

Remember, the inside of the alimentary canal, from the mouth to the rectum, is outside the body, although it runs through it. In other words, it is part of the body’s immediate environment, just as dirt on your skin is external to the body. In fact, the lining of the intestines is made from the same matrix of tissue (ectoderm) as skin. It’s a membrane. In other words, it’s skin.

The brain and nervous system are also made from the same matrix, the ectoderm. Skin is an organ of elimination and has intelligence. It is a very permeable membrane, however, letting in what will nourish the body and eliminating what is toxic and not handled by the other organs and glands of elimination. The pH of the skin is a crucial aspect of its integrity. High acidity will break it down. Inflammation is created by the immune system, which is very pervasive throughout the intestines and colon, in order to deal with the foreign substance that is irritating the membrane.

It is literally a fire, a localized febrile condition created to burn up toxins and dying cells.

Food that is not properly digested will cause acidity in the intestines. Undigested protein will rot causing putrefaction. Undigested carbohydrates will ferment. Undigested fats will go rancid. Rancid fats destroy tissue immediately upon contact. This is why it is not good to eat rancid seeds and nuts or use rancid cooking and salad oils. They also destroy HDL, the so called “good” cholesterol. Cholesterol is essential to the structural composition of the cell wall . . . every one of the 100 trillion cells that make up your body.

Digestion of Proteins and Carbohydrates
Protein is broken down and digested in the stomach by hydrochloric acid (HCL). Hydrochloric acid is secreted by the parietal cells lining the stomach at a pH (potential of Hydrogen) of 0.8, very acidic, and by the time it mixes with the stomach contents its pH increases to about 2.5. Pepsin is the activating enzyme for HCL, but it can do so only in this high acidic condition.

This is why it is not smart to mix carbohydrates and sweets with meats in the same meal, as these foods set up an alkaline condition in the stomach, which will prevent pepsin from activating HCL, which in turn leads to indigestion. This also goes for the digestion and conversion of carbohydrates into sugar, which takes place largely in the mouth.

Ptyalin (salivary amylase) is the activating enzyme for carbohydrate digestion and it needs an alkaline condition to do its job properly. So, you can see how these two chemistries are not compatible together in the stomach at the same time. These enzymes are mixed with the food during mastication – which is why it is important to chew food thoroughly before swallowing it. Lypase is the activating enzyme for the digestion of fats.
(Note: HCL production in the stomach begins to decline around age 45, and our enzyme reserve runs low, so it is supportive of digestion to take digestive enzymes and probiotics)

Poor Digestion and Stress
The function of the parietal cells, like all cells in the body, depends largely upon adrenalin. This is why when a person is under stress, it is not wise to overeat, especially too much protein although protein is important so isotonic Bromelain could help. Bromelain is the enemy of proteins. Proteolytic enzymes modulate blood proteins, antioxidant levels, cytokine and chemokine levels, cellular adhesion molecules and free radicals. (A failure to balance any of the above may lead to less than optimal immunity, cell division or repair of internal mechanisms, part of the picture being described.)

Vegetables and fruit are more easily digested during stressful times. Stress puts the body in fight or flight mode sending most of the adrenalin to the muscle cells.

The body is not interested in growth and healing when it is focused on survival or running away from a stressor, such as a charging bull, a stressful job or lifestyle, or long-term grieving and mental and emotional distress. Toxins inhaled or ingested bring on stress just as surely as any other external stressors. This is why cigarette smoking keeps the lining of the stomach inflamed, mainly from the chemicals (some 300 of them in the paper and tobacco).  Also the polymorphism MTHFR tends to contribute to a buildup of toxins so digestive orders are on the list of conditions associated with this genetic polymorphism.

Poor nutrition puts the body cells in a state of starvation stress as well. When there’s stress, the parietal cells of the stomach shut down the production of hydrochloric acid, rendering protein digestion problematic. Mental and emotional stress also produces acidosis throughout the body.

When protein is not digested properly produces putrid matter. Putrefaction produces organic acids, which will erode the stomach and intestinal linings. The acids of putrefaction and fermentation are what cause “acid indigestion” and “heart burn.”

It is not the hydrochloric acid that causes these symptoms, including ulcers. In fact, it is the lack of hydrochloric acid that creates the condition of indigestion that leads to putrefaction of proteins. So when a person has “heart burn” after eating, while antacids do relieve the symptoms, they also cancel out the hydrochloric acid needed for digestion. This sets up a condition for rotting meat and putrefaction of proteins in the gut further down the alimentary canal until the gas-producing material is finally eliminated. While this putrid matter is in the gut, however, it causes all sorts of assault to the intestinal lining, creating the conditions for Crohn’s disease and cancer to develop.

So when a person has “acid indigestion” and “heartburn” s/he needs some digestive support. MTHFR can also impact the creation of betaine in the methylation cycle and as mentioned previously digestive issues are symptomatic of this genetic mutation.  Many people also have genetic mutations impacting their ability to digest carbohydrates like ACE, PPARG, ADRB2, FABP2 and TCF7L2.

Fat genetic mutations will also be challenging for the digestive tract like FTO, LPL, FABP2, APOC3 and APOA2.

To take chemicals that stop the production of digestive stomach acids only adds insult to injury. We have to add digestive acids to the stomach not eliminate them. Pharmaceutical grade Aloe Juice for calming the digestive tract, antioxidants for healing it, Active B Complex (5-MTHF) to support MTHFR, digestive enzymes and probiotics are one of the solutions. IV or Isotonic delivery is important because the digestive tract is stressed. Isotonic delivery skips the whole process and goes right to the cells that need relief.  Isotonic Wellmune is also recommended as it contains patented beta-glucans that activate your innate immunity to better react to and neutralize foreign invaders of your body. It can also benefit the “depression” described above associated with TNF.

The Digestive Process and the pH Factor
The gallbladder and pancreas produce copious amounts of sodium-rich bile and alkaline juices respectively to emulsify fat and buffer the 2.5 pH acids of digestion in the chyme (stomach contents) coming out of the stomach into the duodenum, the first 12 inches of the small intestines. The intestines, which are ideally happy with a 5.8 to 6.2 pH, would be distressed and burned by 2.5 pH content.
So, it is important that the gallbladder and pancreas produce their alkaline substances to buffer this acid. Otherwise duodenal ulcers may develop. The colon, on the other hand, likes a more acidic environment – for one thing, to keep yeast and fungus from growing and thereby giving rise to infection.

What can cause these alkaline substances to be depleted of alkalizing sodium? Well, for one thing, over consumption of acid-producing foods – grains and proteins – which use a lot of acid-buffering sodium. What builds up sodium reserves? Vegetables, especially celery and cucumbers, and some fruits, such as prunes, plums and blueberries, are alkaline producing foods that build up your sodium reserves. These alkaline-producing foods should ideally make up 80% of our diet.

When bile loses it alkalinity, it becomes thick and therefore cannot easily flow through the small common-bile duct. Fat is not emulsified and therefore hardens to form stones. Calcium will precipitate out of solution and crystallize, creating calcium stones. When bile does not flow into the duodenum through the common-bile duct, the acid of the chyme does not get properly buffered and the fats are not emulsified. This creates an acid condition that will burn the small intestines, causing irritable bowel (IBS) and colitis.

Bacteria, viruses and other pathogens will thrive in this acid environment. This leads to inflammation and infection, the immune system’s way of dealing with pathogens. Crohn’s disease develops as the lining of the intestines begins to get raw, eaten up by these organic acids. This is why it will appear as “raw hamburger meat” in a colonoscopy. In this compromised condition, bacteria and viruses, along with undigested proteins and other toxins, easily enter the blood stream through the “leaky gut,” causing so-called “food allergies,” as well as infection throughout the body, including the kidneys and bladder, organs of elimination of toxic waste fluids.

Symptom Relief without side effects

Pharmaceutical grade Aloe Juice has anti-bacterial, anti-viral and anti-carcinogenic properties.  It calms and soothes skin, especially burning skin inside and out. Most Aloe product are not pharmaceutical grade. Antioxidants will repair cellular damage and scavenge free radicals. Isotonic delivery is recommended for optimal bioavailability.

5-MTHF will help the methylation cycle and DNA repair and functioning.  Digestive Enzymes and Probiotics will help digestion and boost and support good bacteria in the gut. Many health professionals have written books on how bad industrialized food is now.  We are seeing epidemics of digestive disorders in young people. This generation faces the worst toxic burden so far. GMOs have BT toxin injected into their DNA. Much more glyphosate is used on GMO food with surfactants (Roundup) that make it worse.  It is patented as an antibiotic therefore likely contributes to stronger toxic bacteria that are resistant.  The World Health Organization has classified glyphosate as a class 1 carcinogen. Organic food is recommended.  Eliminate endocrine disruptors from the environment as much as possible.


The “cure” of Crohn’s disease lies in the healing of the lining of the intestinal wall, factoring in genetics and epigenetics. It also includes treating and clearing the underlying energetic patterns of stress, as mentioned at the start of this article.

Emotional Factors

In her wonderful and popular book, “You Can Heal Your Life,” Louise Hay suggests that behind inflammation in the colon (ileitis), which is what Crohns is, may be a deep sense of fear and worry of not being “good enough.” This deeply rooted pattern was likely put there early in childhood by a well-meaning parent who tried to motivate a child by telling her how stupid she is, screaming and berating her for not being able to do anything right.

A new thought pattern she offers could be: “I love and approve of myself. I am doing the best I can. I am wonderful. I am at peace.”


This infographic identifies all of the genetic variants named in this article. It is a snapshot of the 45 genetic polymorphisms that each have 3 independent clinical studies showing a change in expression with a change in lifestyle. The company does not sell DNA to pharmaceutical companies. These are my results.  Notice I have a very high sensitivity to carbohydrates and medium sensitivity to fats.  I knew that from my experience but I did not know I had genetics that put me at risk for Celiac Disease.  The B vitamin snapshot shows I have MTHFR. I have used all the protocols I describe.  Other symptoms of mine that have disappeared are allergies, sinus headaches, night terrors and heart palpitations.  Notice I also have a need for extra Omega III and Vitamin D as well as cruciferous and alium vegetables.  (Curcumin in the form of BCM-95 with tumeric and added broccoli concentrate can also benefit in a pinch if you can’t get your 6-12 servings of vegetables in.  That is tough for anyone working full time. To have quality food you darn near have to grow your own.  Add  in lack of nutrients in the soil, premature harvesting, pesticides, methyl mercury fallout from burning coal, pharmaceutical contamination of water, compromised environmental policies by moneyed corporate interests controlling politics, etc. can we really expect to achieve optimal health just from eating food?)


This article took me 12 years to write.  It is compiled from many cutting edge professionals, one of the top genetic scientists in the world, Dr. Keith Grimaldi, my work with cutting edge Allopathic health professionals and CAMs, and my own urgency to help someone I love deeply.  There is plenty of science to back up all of it.  I learned by Googling, Pubmed, science based sites, scientists and health professionals who have success. We all need science but none of us should have to wait the years it will take for clinical studies and medical schools to catch up, especially when the protocols are benign and effective and there are pharmaceutical and insurance moneyed interests blocking many progressive moves toward prevention and optimal health.  To learn more in detail about protocols go to my youtube channel, Kathy Kaufman Videos.  Write me at kathy@criticalhealth.org.

A special thanks to my dear friend Michael Sweringen of Microleadership.  He helped lead me to all of the climate and environmental information that got me thinking about epigenetics.  And Dr. Keith Grimaldi, a brilliant and good man.

And lastly, the FDA has not evaluated any of this information. If only they would.

Weight Management


One Size Doesn’t Fit All

Weight Management is personal.  People are different.  Have you noticed?  Should you be on a low carb diet?  Well if you look at the genetics of the person below the answer is resoundingly YES.

He is very sensitive to carbohydrates and saturated fats. He has a high risk of injury so he has to consider that with his exercise program and he should be adding power and endurance.  After all, muscle dictates metabolism.


Some people are not sensitive to carbohydrates and they should be eating more of a Mediterranean style diet.


Some people have genetics that make them more leptin sensitive, they are genetically prone to higher levels of inflammation.  They need more Omega III or Vitamin D.


We all need personalized intervention!




A Core Ingredient for Weight Loss


By Dr. Nancy J. Miller-Ihli

Successful weight loss requires that we address inflammation, satiety, and metabolic challenges.  Leptin is a hormone that plays a key role in regulating energy intake and energy expenditure, including appetite/hunger and metabolism. Overweight individuals have elevated leptin levels yet are resistant to the normal effects of leptin.

LeptiCore – a patent-pending nutraceutical complex of plant-based polysaccharides, esterified fatty acids, pomegranate extract, beta-carotene, and more – has been clinically shown to reduce leptin levels as well as systemic inflammation.  The result is enhanced leptin function which means people feel full sooner (improved satiety), their metabolism is more efficient (improved thermogenesis,) and they have good blood sugar control allowing them to achieve and maintain a healthy weight.

LeptiCore is also formulated with blue-green algae, which contains phenylethylamine (PEA) known to enhance mood by raising serotonin levels. This is an important element for weight loss, as improved mood has been shown to help individuals avoid stress-eating.

As a scientist and health professional, I always want to back up my nutritional recommendations with hard facts. And the studies done on LeptiCore are very exciting.

For example, a recent eight-week study* published in the journal Lipids in Health and Disease highlighted LeptiCore’s weight management and metabolic wellness benefits. This study found that taking 600 mg of LeptiCore daily decreased body weight, body fat, waist and hip circumference, lowered leptin and c-reactive protein levels, and improved blood sugar balance, blood lipid profiles and serotonin levels.




It is excellent that body fat was monitored in the study, because it showed fat was lost rather than muscle or water.  Also, reducing body fat – particularly in the abdomen, as shown by decreased weight and hip measurements – significantly reduces health risks.

One more thing: in this study, participants achieved these great results WITHOUT modifying their food choices.  Just imagine what can be achieved when LeptiCore is combined with a healthy, low-glycemic eating program and proper exercise.  The results can be outstanding!

Studies like this show that LeptiCore offers great support to individuals who want to lose weight, and improve their body composition and cardiovascular health. In my opinion, LeptiCore is much more than a weight loss ingredient. It is really a wellness ingredient because it can positively impact so many aspects of health.


*Source: Kuate et al, The use of LeptiCore in Reducing Fat Gain and Managing Weight Loss in Patients with Metabolic Syndrome, Lipids in Health and Diseases (2010) 9:20

Nancy Miller-Ihli, PhD, is a former USDA National Program Leader for Nutrition and is a guest member of the nutraMetrix clinical faculty.  She is the senior author of more than 70 peer-reviewed publications and has authored a white paper on obesity for the White House.  Dr. Miller-Ihli is a strong proponent of low-glycemic impact eating as part of a healthy lifestyle and is committed to community-based nutrition education.


Nutrition, Environment & Genetics Taking Control of your Health


I want YOU to join us for this unique, cutting edge approach!!!

May 2nd, 2015 1:30 – 3:30  Princeton, New Jersey


It is not as easy as it used to be: foods are genetically altered, the environment is polluted…Genetics is like a loaded gun & environment is the trigger.


My Dad died at a very young age of a massive heart attack, I’ve had very close calls at least three times because of interactions to medication, and thirteen of my friends have died from breast cancer.  I’m the only sixty something I know that isn’t on some prescription for something.

– Kathy

In the past 2.5 years, I lost my brother in a car accident, our mother had a stroke, and our Dad’s Rheumatoid Arthritis and Lung Disease have worsened.

– Dr. Mary Boname


 We do not want biology to be destiny. We took control & you can too.


When certain parts of the human genome are turned off or on, this can manifest as disease–poor digestion, detoxification, autism, birth defects, anxiety, depression, diabetes, cancer, and the list goes on and on.


Lifestyle factors–food, exercise, stress, toxins, environment, and sleep–are the epigenetic control levers. The research and science shows this without a doubt.


The good news is you have CONTROL over most of these factors. We can work together to achieve optimal health.


Dr. Mary Boname of Montgomery Eye Care invites you to come learn how you can influence genetic expression!


Dr. McKenzie has been a practicing pediatrician in the Boston area for over 30 years!


Meet fellow health professionals and community members who are looking for information and solutions.

RSVP Kathy Kaufman


Kathy.kaufman@gmail.com 617 515-7559

Holiday Greetings


You are goodness and mercy and compassion and understanding.

You are peace and joy and light,

You are forgiveness and patience, strength and courage,

A helper in time of need, a comforter in time of sorrow,

A healer in time of injury,

And a teacher in times of confusion,

You are the deepest wisdom and the highest truth,

The greatest truth and the grandest love

You are these things and at moments in your life you have known

Yourself as these things

Choose now to know yourself as these things always



The Four Nutraceutical Ingredients Everyone Should Look at for Fitness

By Kerri Whatley


Everyone is trying to get healthy and fit and while doing so, your body needs extra vitamins and nutrients. It is simple really, you can’t deplete something without having to replenish it. The same goes for your body. Sometimes our bodies aren’t getting enough of what it needs to begin with, and that could start the “get fit” process off on the wrong foot.

1) Branched Chain Amino Acids that have anabolic effects on protein metabolism by raising the rate of protein synthesis and lowering the rate of protein degradation in resting human muscle. Also, during recovery from endurance exercise, BCAAs were found to have anabolic effects in human muscle.

A study published in the National Institute of Health showed “When BCAAs were supplied to subjects during and after one session of quadriceps muscle resistance exercise, an increase in mTOR, p70 S6 kinase, and S6 phosphorylation was found in the recovery period after the exercise with no effect of BCAAs on Akt or glycogen synthase kinase 3 (GSK-3) phosphorylation. Exercise without BCAA intake led to a partial phosphorylation of p70 S6 kinase without activating the enzyme, a decrease in Akt phosphorylation, and no change in GSK-3.”These findings show that the Branched Chain Amino Acids help with the recovery of the human muscle after a workout


2) Pine Bark, also known as Pycnogenol, has been shown to help with cramps and muscle pain before during and after a workout. A study found in the U.S. National Medical Librarywas done to assess the prevention of cramps and muscular pain with the use of Pycnogenol. The study was done over a 9 week period (5 weeks of activity with Pycnogenol and 4 without) to study the effects Pycnogenol plays on the body. Research suggests that the use of Pycnogenol prevents cramps, muscular pain at rest, as well as pain after or during exercise.

Stated in the report, “The difference is statistically significant considering objective observations (cramps episodes) and evaluating more subjective aspects (score). This indicates that Pycnogenol is effective in reducing pain and cramps during retraining and rehabilitation increasing its efficiency. In starting any physical rehabilitation program, particularly in vascular subjects, the limitation in mobility associated with muscular pain and with cramps tends to be relevant, and controlling these symptoms is useful to speed up the retraining process.”

3) While trying to achieve the most from your work out you can add activated B vitamins to help give you the energy you need. By using these advanced forms, the body has to work less for utilization and effectiveness is increased. Folinic acid, 5-MTHF, methylcobalamin (B12) and pyridoxal 5’ phosphate (B6) is known to promote cardiovascular health. Additional B vitamins such as B1, B5, niacin and biotin support many processes allowing this product to work via several mechanisms to increase energy, promote cardiovascular health, decrease stress and improve mood while helping to maintain normal serotonin levels.

Vitamin B12 also takes part in metabolism, along with the other B vitamins. The vitamin helps our bodies convert the food we eat and turn it into the energy we need. The B vitamins also help the body digest proteins and fats. This helps your body use the food you eat more efficiently as fuel.

4) While working out is great if your bones can’t handle the activity, you won’t get very far. Vitamin D promotes the efficient intestinal absorption of calcium, by supporting the synthesis of calcium-binding proteins to promote normal calcium absorption and retention. Vitamin D also promotes the normal formation of bone and normal bone growth, and bone remodeling by osteoblasts and osteoclasts. Daily supplements of vitamin D3 may improve certain markers of heart health like HDL cholesterol, and lead to significant reductions in body fat mass in overweight and obese people, says a new study posted in the British Journal of Nutrition.

Methylation – Notes from the Cutting Edge

Methylation ….

Turn genes on and off

Process chemicals and toxins (biotransformation)

Build neurotransmitters (dopamine, serotonin, epinephrine)

Process hormones (estrogen)

Build immune cells (T cells )

DNA and RNA synthesis

Produce energy (CoQ10, ATP, carnitine)

Produce protective coating on nerves

Methylation can be disrupted by

Lack of cofactors driving methylation forward (zinc, magnesium, B6 )

Medications (antacids)

Specific nutrients depleting methyl groups (niacin)

Environmental toxicity, heavy metals, chemicals (acetylaldehyde, arsenic, mercury)

Excessive substrate (Feedback inhibition; too much cysteine, SAMe, glutathione)

Genetic mutations

Prevalent Conditions


Diabetes Fibromyalgia
Cancer Chronic Fatigue Syndrome
Pulmonary Embolisms Depression
Cleft Palate Alcoholism
Spina Bifida Addictive Behaviors
Autism Insomnia
Parkinson’s Down’s syndrome
Atherosclerosis Chronic Viral Infection
Neural Tube Defects Thyroid Dysfunction
Immune deficiency Neuropathy
ADD/ADHD Recurrent Miscarriages
Multiple Sclerosis Infertility
Alzheimer’s Anxiety
Dementia Schizophrenia
Chemical Sensitivity Bipolar
Congentital Heart Defects Allergies



Industrialized farming and ranching (poor nutrition, chemical exposure)

Increased stressors (longer work hours, less sleep, more demands, faster society, technology, digital dementia)

Pervasive chemicals (school, work, food, water, air, soil, products)

Standardized healthcare (symptomatic treatment vs understanding underlying causes)

Lack of education: unaware of common everyday harmful exposures

Lobbyists (protecting big business)


Balance Methylation

Multifaceted approach: The Basic Five

lifestyle, diet, environment, mental outlook, nutrition

The approach is demanding, requires patient education, is difficult to achieve,

Hard to maintain and takes time BUT

It is required and sometimes it is still not enough


Test for MTHFR – C677T and A1298C

Still not improving?

MTR/MTRR – recycles B12 and processes B12 for methionine production

GSTM1 and SOD – major detoxification enzymes

CBS – processes homocysteine and if upregulated depletes methyl groups

Increases taurine

NOS – processes ammonia, forms nitric oxide from argenine

COMT and MAO A – processes and neurotransmitter catabolism and estrogens

GAD – transforms glutamate into GABA

HNMT- processes histamine (secondary enzyme for histamine – primary is DAO)

QDPR – recycles BH4

SUOX – processes sulfites/sulphur, and this mutation is made worse from CBS

upregulation; people with this may get worse when they detox as sulfur by

products are prominent during detox


Who Should be Screened?


Diabetes Fibromyalgia PreConception
Cancer Chronic Fatigue Syndrome Newborn
Pulmonary Embolisms Mental Health Syndromes Cervical Dysplasia
Cleft Palate Alcoholism Birth Defects
Spina Bifida Addictive Behaviors Drug/supplement Sensitivities
Autism Insomnia Chronic Pain
Parkinson’s Down’s syndrome Elevated histamine
Atherosclerosis Chronic Viral Infection Elevated Cobalamin
Dementia Thyroid Dysfunction Congentital Heart Defects
Immune deficiency Neuropathy Allergies
ADD/ADHD Recurrent Miscarriages Chemical Sensitivity
Multiple Sclerosis Infertility Bipolar
Alzheimer’s Anxiety Schizophrenia


Test Everyone





Group One C677T Variant Two C677T Variants One C282Y and One A1298C Variants Two a1298CVariants
Caucasian 25 – 45% 8 – 18% 15 – 20% 4 – 12%
Hispanic US 42% 21% Not known 25%
Black US 14% 1% Not known 2 – 4%
Asian 35% (Japanese 11% (Japanese) Not known 1 – 4%


Having two MTHFR  variants is more common than having high homosysteine or any condition linked to high homosysteine.  Atlantic Health. Dnadirect

Learn more at MTHFR.net





Happy New Year 2014


What have we learned?

“Scientists now see inheritance as more fluid, and the barriers between genes and the environment as more porous.

It’s not all about the genes anymore; it’s about expressing genes, or turning them on and off.  Cells commonly turn DNA off by dotting it with small bumps called methyl groups, or turn DNA on by using acetyl groups to uncoil it from protein spools. ( Read more)

We have changed the climate.

The air is warming and the excess moisture is contributing to more severe weather.

The oceans are becoming more acidic.

We’ve industrialized food.  Grassroots local food movements have sprung up but the incentives are built in for big corporate farming.

Because of the industrialization of food and premature harvesting most food is lacking in minerals and enzymes.  Because of the incentives junk food is cheap.

There is a diabetes epidemic.  The US is the second fattest country in the world.  Mexico is number one.

Coal burning plants used for our electrical grid produce a by-product of methyl mercury.  Methyl mercury is found in high quantities in the ocean (along with other toxins) and is also now being found in root vegetables.

Fracking from gas extraction results in flowback and produced water containing sodium, magnesium, iron, barium, strontium, manganese, methanol, chloride, sulfate, benzene, toluene, ethylbenzene, xylene and natural radioactive substances.

Aside from the by-products of fossil fuels we haven’t seen any dinosaurs lately so sustainable energy has become a priority – at least in other parts of the world.  Germany has more than 300,000 solar homes and it is not a sunny country.

I live in a solar home and it didn’t cost any more to build than one that isn’t.  When storms took out the grid, I still had power. Companies like Solar City, a Google backed company can provide the solar systems without the upfront expense.

There are wind and solar companies now that can provide electricity for the grid.

We have polluted the environment with pesticides, chemicals, drugs, genetically modified organisms including inserting BT toxin into the DNA of food which is showing up in the digestive tract of newborns according to clinical studies in the UK.

We have discovered patients are different.  Their genetics are different.  A one size fits all approach to health does not make sense anymore.

There are MDs curing so called “incurable” diseases by running the human genome and treating the patient based on their genetics.  A doctor in Texas has been doing this for ten years but his treatment does not fit the approval process of the FDA because it is personalized.

There are medical devices now that can help prevent adverse cardiac events ten years in advance.

There are MDs using these devices to prevent issues by helping patients make lifestyle changes to support their genetics.

I do not have the symptoms of inflammatory diseases that I had previously because ten years ago I did a genetic screening, changed my lifestyle and cleaned up my environment.

Despite overwhelming scientific evidence there is still a fundamental disconnect between medical and nutritional mindsets and flawed studies on both sides.

The US pays the highest healthcare costs in the Western World.

The costs of clinical studies are exorbitant.

A gene can be patented but a natural substance cannot.

Experts wouldn’t expect a pill to have the same impact as an IV. They know all versions of drugs aren’t as effective.  Some create worse side effects than others.

However supplements and nutraceuticals are all lumped together.  Most MDs tell their patients to just go anywhere to get them.

The FDA does monitor them but not the way they monitor pharmaceuticals and that is because they usually don’t kill people.

I’ve seen clinical studies on an isotonic solution compared to the same exact powder compressed in a pill form.  The difference in results is dramatic.  And I expect if anyone bothered to study it, there would be differences based on genetics.

This would be true of pharmaceuticals and nutraceuticals.  Some individuals benefit, some could be harmed and some have no impact at all depending on their genetics.


Some Interesting facts supported by science based studies:

40% of Americans have the MTHFR Gene SNP

Folic Acid fortification may be causing an increase of MTHFR defects

MTHFR can be related to birth defects and many disease symptoms

47% of Americans take at least 1 prescription drug each month

Close to 100% of prescription drugs deplete some component of B complex

Once a patient is taking 2 prescription drugs, they are likely to be put on an antidepressant

Host resistance and susceptibility to influenza depend importantly on the ratio of vitamin D to vitamin A activity

A 25-hydroxy serum level of 55 is needed to prevent the flu

Researchers have shown that vitamin D status is associated with the immune system, the production of cytokines and chemokine signaling.

Resveratrol can activate the SIRT1 gene.  This has only previously been demonstrated with caloric restriction.

Gene SNPS that have been clinically shown to be involved in weight management and express or not based on lifestyle i.e. the patients can impact these by their lifestyle choices: ACE, ADRB2, PPARGC1A, CRP, IL6, TNFalfa, ENOS.

New clinical studies on weight management will be implemented into genetic screenings this year.

By 2015 the area of nutrigenomics will have exploded dramatically.

Patients are extremely interested in preventing disease as demonstrated by their buying decisions.

The ACA (Affordable Care Act) is now law. Incentives for prevention are built in for health professionals and for patients.

Most health professionals have no business training but many are running a business.

The question is will health professionals become healers and help their patients with this quest or continue down antiquated paths that are demonstrating abominable results and leave their patients to make poor decisions based on marketing alone.

Some health professionals will learn to understand the concept of leverage, the missing ingredient in most Americans lives.  Some will be forced into being hospital employees or employees of other kinds of medical corporations or go broke.

This will be a breakthrough year for some health professionals.  They will change their own health, the health of their patients and they will turn their occupation into an avocation because they will have their time back.

METHYLS and ACETYLS; You gotta lot of splainin to do

Ehyl and Lucy

“Scientists now see inheritance as more fluid, and the barriers between genes and the environment as more porous.

It’s not all about the genes anymore; it’s about expressing genes, or turning them on and off.  Cells commonly turn DNA off by dotting it with small bumps called methyl groups, or turn DNA on by using acetyl groups to uncoil it from protein spools.

And scientists now know that cells pass those precise patterns of methyls and acetyls on to daughter cells whenever they divide – a sort of “cellular memory.”  (Indeed, scientists once thought that the methyls in neurons physically recorded memories in our brains.  That’s not right, but interfering with methyls and acetyls can interfere with forming memories.)

The key point is that these patterns, while mostly stable, are not permanent: certain environmental experiences can add or subtract methyls and acetyls, changing those patterns.  In effect this etches a memory of what the organism was doing or experiencing into its cells.

Unfortunately, bad experiences can be etched into cells as easily as good experiences.  Intense emotional pain can sometimes flood the mammal brain with neurochemicals that tack methyl groups where they shouldn’t be.

Mice that are (however contradictory this sounds) bullied by other mice when they’re pups often have these funny methyl patterns in their brains.  As do baby mice (both foster and biological) raised by neglectful mothers, mothers who refuse to lick and cuddle and nurse.

These neglected mice fall apart in stressful situations as adults, and their meltdowns can’t be the result of poor genes, since biological and foster children end up equally histrionic.  Instead the aberrant methyl patterns were imprinted early on, and as neurons kept dividing and the brain kept growing, these patterns perpetuated themselves.  The events of September 11, 2001, might have scarred the brains of unborn humans in similar ways.  Some pregnant women in Manhattan developed post-traumatic stress disorder, which can epigenetically activate and deactivate at least a dozen genes, including brain genes.

These women, especially the ones affected during the third trimester, ended up having children who felt more anxiety and acute distress than other children when confronted with strange stimuli.

Notice that these DNA changes aren’t genetic, because the A-C-G-T string remains the same throughout.

But epigenetic changes are de facto mutations; genes might as well not function.  And just like mutations, epigenetic changes live on in cells and their descendants.  Indeed, each of us accumulates more and more unique epigenetic changes as we age.  This explains why the personalities and even physiognomies of identical twins, despite identical DNA, grow more distinct each year.  It also means that that detective-story trope of one twin committing a murder and both getting away with it – because DNA tests can’t tell them apart – might not hold up forever.  Their epigenomes could condemn them.

Of course, all of this evidence proves only that body cells can record environmental cues and pass them on to other body cells, a limited form of inheritance.  Normally when sperm and egg unite, embryos erase this epigenetic information – allowing you to become you, unencumbered by what your parents did.  But other evidence suggests that some epigenetic changes, through mistakes or subterfuge, sometimes get smuggled along to new generations of pups, cubs, chicks, or children.”





If you Google VDR you’ll usually get hits for Video Disk Recorder but in the health arena VDR (Vitamin D Receptor)  is a powerful gene that encodes the nuclear hormone receptor for Vitamin D3.

This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II Vitamin D-resistant rickets.

It is a key nuclear receptor that binds nutritionally derived ligands and exerts bioeffects that contribute to bone mineral homeostasis, detoxification of exogenous and endogenous compounds, cancer prevention, and mammalian hair cycling. Liganded VDR modulates gene expression via heterodimerization with the retinoid X receptor and recruitment of coactivators or corepressors. VDR interacts with the corepressor hairless (Hr) to control hair cycling, an action independent of the endocrine VDR ligand, 1,25-dihydroxyVitamin D(3).
There is much spin doctoring on the Internet mostly for marketing purposes. I confess I market as well but do my best to be science based. Unfortunately all the marketing can mask real evidence and lead to skepticism.

There is always the crowd who promotes au naturel and insists you can get all your Vitamin D from sunlight and diet.  They clearly do not live in New England or the Northern hemispheres or parts of the planet that are dark for 6 months.

At one time in the earth’s history before polluted environments and industrialized food it may have been true.

But now there is so much dismaying information about the state of the oceans, environment and climate, food farming along with just plain old personal hygiene information I have a hard time believing we can do it anymore.

A pediatrician I work with did quite a bit of research on Vitamin D and said to get enough from the sunlight it would have to stay on your skin for about 24 hours to be converted.
I doubt there are many of us who don’t bathe for that long a period.  There are other skin specialists who say after a few minutes of exposure it is detrimental to your Vitamin D levels.  And then there is the possibility that prolonged exposure to UVR is linked to skin cancer.

Senator Whitehouse of RI did a speech on the state of the ocean and said when a whale beaches up on RI shores; it is considered toxic waste so unless you want a healthy dose of toxic waste in your diet, seafood is a bit risky these days.  I’ve had food poisoning twice from tuna and sadly have now given it up.

Impaired intestinal absorption and reduced metabolism to active forms of Vitamin D are contributing to deficiencies.

We know that genetics are not cast in stone anymore and some genes can be expressed or not based on lifestyle and environment.  Some studies have shown that low levels of Vitamin D in people with autoimmune diseases are not from deficiency but from chronic infections of bacteria that down regulate the Vitamin D metabolism.

These people have been treated with antibiotics which can be problematic as bacteria are very good at mutating and becoming resistant.  And who knows maybe years of over treatment with medications contributed to this problem in the first place?  Some of the sickest people I know who have auto immune diseases have been on the most meds during their lifetime. I personally know two people with Stevens Johnson’s Syndrome who have probably been on twenty times the pharmaceuticals and over the counter meds in their life that I have and they never really had serious conditions that required them.

More than 50% of postmenopausal women taking medication for osteoporosis have suboptimal levels of Vitamin D.

Environmental toxins like herbicides can contribute to the down regulation of vitamin D.

This year a team of academic researchers pinpointed how Vitamin D3 and omega-3 fatty acids may enhance the immune system’s ability to clear the brain of amyloid plaques, one of the hallmarks of Alzheimer’s disease.

In November Johns Hopkins did a study. Patients with low Vitamin D levels were significantly more likely to develop a condition called recurrent inflammatory spinal cord disease. The researchers considered this finding to strengthen the evidence base of an existent link between low Vitamin D levels and immunologic dysregulation.
Vitamin D3 supports the synthesis of calcium-binding proteins.

Without adequate amounts only 1–15% of dietary calcium is absorbed which is critical in the normal formation of bone and normal bone growth and bone remodeling by osteoblasts and osteoclasts. It promotes regulation of T-cell function and through its interaction with VDR it supports the healthy expression of the gene to maintain healthy blood pressure.

K3 in combination with D3 ensures transport to the bones and blood vessels. Only 10% of dietary Vitamin K is in K2 form so it is not easy to get from food.  And increased Vitamin D3 uses up K2 in the body so it makes sense to have them together. In addition novel dietary ligands for VDR like curcumin, gamma-tocotrienol, and essential fatty acid derivatives likely play a role in the bioactions of VDR.

It does matter when it comes to how to get this additional supplementation into the body.  Some products have rancid oil in them leading to UTIs (Urinary Tract Infections).

IV is the optimal form of delivery to the body so anything that is designed to mimic that and has the science to prove it should be of interest to health professionals.
Recently I’ve met so many more professionals who are taking the time to learn the science to advise their patients but they drop the ball when it comes to where the patient should get the solution.

The FDA does not monitor the industry so professionals really need to be educated when they advise patients.

Just go to Amazon or CVS is what patients tell me they were advised to do.

If I go online or to a store I experience the same dilemma I did in the supermarket when my children were little and I was in the cereal aisle. It was a little easier with cereals.  I told my son anything with less than 5 sugars which served to educate him on all the different kinds of sugars and served me as I knew the only one would be Cheerios.

And I could use them for toilet training.  Shoot for the center I told my son.

Unfortunately, I don’t think we want to play games with nutrition. I played the shotgun approach for 40 years wishing my doctors could advise me and just tell me the good one. I probably took many things I didn’t need and wasted my money because it wasn’t getting into my system.  When  patients are surveyed many express they feel this way.

Three elderly patients told me they were instructed by their doctors not to take Vitamin D3 because it contained Vitamin K.  I’m guessing their doctors were thinking of Vitamin K1 which is concentrated primarily in the liver and at high doses may interfere with anticoagulant medications.

But the fact that some doctors were unaware of the difference in the two K Vitamins compounded by the fact that lack of patent incentives means a dearth of  scientific evidence in the US is a case for more preventive education in medical school and in continuing medical education where the education is now heavily weighted towards the pharmaceutical industry that is rewarded by patents.

And as we move into the Fall/Winter season the evidence of adequate intake of not just Vitamin D3 with K2 but all essential nutrients in preventing viruses and upper respiratory infections is important, especially for children and the elderly. If we can’t make it we need to take it.

The future is very exciting.  The research is moving at a fast pace due to the resurgence of rickets and the prevalence of autoimmune disease.

Finally this season is different.  The Affordable Care Act is being implemented and rewards patients and doctors for prevention and not just in the form of expensive medical tests.  It’s about time so we all don’t have to keep playing the shotgun approach. Thankfully President Clinton who has a knack for simplifying what others have tried to obfuscate is making the rounds speaking on the benefits of the ACA.